Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13188 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
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Santos, Adriana CarvalhoAlves, Marcelo RibeiroWeide, Luciene Carvalho CardosoNunes, JoyceKuhnert, Lia Rafaela BallardXavier, Analucia RampazzoCunha, SamuelHahne, MichaelVilla-Verde, Déa Maria SerraPinto, Carla Eponina Carvalho2016-03-16T13:42:01Z2016-03-16T13:42:01Z2015SANTOS, Adriana Carvalho et al. Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes. Plos One, v. 10, n. 10, p. 1-8, Oct. 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1318810.1371/journal.pone.0140150engPublic Library of ScienceDecreased Circulating Levels of APRIL: Questioning Its Role in Diabetesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Centro de Pesquisa Clínica em HIV/AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Patologia Experimental. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Patologia Experimental. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Niterói, RJ, Brasil.Institute of Molecular Genetics of Montpellier. Montpellier, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Patologia Experimental. Niterói, RJ, Brasil.Diabetes mellitus is a chronic disease that affects over 382 million people worldwide. Type- 1 Diabetes (T1D) is classified as an autoimmune disease that results from pancreatic β-cell destruction and insulin deficiency. Type-2 Diabetes (T2D) is characterized principally by insulin resistance in target tissues followed by decreased insulin production due to β-cell failure. It is challenging to identify immunological markers such as inflammatory molecules that are triggered in response to changes during the pathogenesis of diabetes. APRIL is an important member of the TNF family and has been linked to chronic inflammatory processes of various diseases since its discovery in 1998. Therefore, this study aimed to evaluate APRIL serum levels in T1D and T2D. For this, we used the ELISA assay to measure serum APRIL levels of 33 T1D and 30 T2D patients, and non-diabetic subjects as control group. Our data showed a decrease in serum APRIL levels in T1D patients when compared with healthy individuals. The same pattern was observed in the group of T2D patients when compared with the control. The decrease of serum APRIL levels in diabetic patients suggests that this cytokine has a role in T1D and T2D. Diabetes is already considered as an inflammatory condition with different cytokines being implicated in its physiopathology. Our data suggest that APRIL can be considered as a potential modulating cytokine in the inflammatory process of diabetes.Diabetes mellitusAPRIL serum levelsDiabetesCytokineDiabetes mellitusCitocinasDiabetesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13188/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALadriana_santos_etal_IOC_2015.PDFadriana_santos_etal_IOC_2015.PDFapplication/pdf375512https://www.arca.fiocruz.br/bitstream/icict/13188/2/adriana_santos_etal_IOC_2015.PDFa5678840841c4c2d4bc7da295d008fd8MD52TEXTadriana_santos_etal_IOC_2015.PDF.txtadriana_santos_etal_IOC_2015.PDF.txtExtracted texttext/plain27601https://www.arca.fiocruz.br/bitstream/icict/13188/3/adriana_santos_etal_IOC_2015.PDF.txt8d1788059be8c7a1c6ff2ee572524791MD53icict/131882023-09-05 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| dc.title.pt_BR.fl_str_mv |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes |
| title |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes |
| spellingShingle |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes Santos, Adriana Carvalho Diabetes mellitus APRIL serum levels Diabetes Cytokine Diabetes mellitus Citocinas Diabetes |
| title_short |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes |
| title_full |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes |
| title_fullStr |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes |
| title_full_unstemmed |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes |
| title_sort |
Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes |
| author |
Santos, Adriana Carvalho |
| author_facet |
Santos, Adriana Carvalho Alves, Marcelo Ribeiro Weide, Luciene Carvalho Cardoso Nunes, Joyce Kuhnert, Lia Rafaela Ballard Xavier, Analucia Rampazzo Cunha, Samuel Hahne, Michael Villa-Verde, Déa Maria Serra Pinto, Carla Eponina Carvalho |
| author_role |
author |
| author2 |
Alves, Marcelo Ribeiro Weide, Luciene Carvalho Cardoso Nunes, Joyce Kuhnert, Lia Rafaela Ballard Xavier, Analucia Rampazzo Cunha, Samuel Hahne, Michael Villa-Verde, Déa Maria Serra Pinto, Carla Eponina Carvalho |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Adriana Carvalho Alves, Marcelo Ribeiro Weide, Luciene Carvalho Cardoso Nunes, Joyce Kuhnert, Lia Rafaela Ballard Xavier, Analucia Rampazzo Cunha, Samuel Hahne, Michael Villa-Verde, Déa Maria Serra Pinto, Carla Eponina Carvalho |
| dc.subject.en.pt_BR.fl_str_mv |
Diabetes mellitus APRIL serum levels Diabetes Cytokine |
| topic |
Diabetes mellitus APRIL serum levels Diabetes Cytokine Diabetes mellitus Citocinas Diabetes |
| dc.subject.decs.pt_BR.fl_str_mv |
Diabetes mellitus Citocinas Diabetes |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
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2015 |
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2015 |
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2016-03-16T13:42:01Z |
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2016-03-16T13:42:01Z |
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SANTOS, Adriana Carvalho et al. Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes. Plos One, v. 10, n. 10, p. 1-8, Oct. 2015. |
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https://www.arca.fiocruz.br/handle/icict/13188 |
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1932-6203 |
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10.1371/journal.pone.0140150 |
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SANTOS, Adriana Carvalho et al. Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes. Plos One, v. 10, n. 10, p. 1-8, Oct. 2015. 1932-6203 10.1371/journal.pone.0140150 |
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