Study of the effects of ß-myrcene on rat fertility and general reproductive performance

Detalhes bibliográficos
Autor(a) principal: Paumgartten, Francisco José Roma
Data de Publicação: 1998
Outros Autores: Carvalho, Rosângela Ribeiro de, Madi, Kalil, Chahoud, Ibrahim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29234
Resumo: Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
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spelling Paumgartten, Francisco José RomaCarvalho, Rosângela Ribeiro deMadi, KalilChahoud, Ibrahim2018-10-02T14:36:33Z2018-10-02T14:36:33Z1998PAUMGARTTEN, Francisco José Roma et al. Study of the effects of ß-myrcene on rat fertility and general reproductive performance. Brazilian Journal of Medical and Biological Research, v. 31, n. 7, p. 955-965, 1998.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/2923410.1590/S0100-879X19980007000121414-431XengAssociação Brasileira de Divulgação CientíficaMonoterpenosÓleos VoláteisFertilidadeCrescimento & Desenvolvimentoß-MyrceneMonoterpenesEssential OilsReproductive ToxicityFertilityEmbryofetal ToxicityPostnatal DevelopmentMonoterpenesOils, VolatileGrowth & DevelopmentFertilityStudy of the effects of ß-myrcene on rat fertility and general reproductive performanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.Freie Universitaet Berlin. Institut fuer Toxikologie und Embryopharmakologie. Berlin, Germany.ß-Myrcene (MYR) is a monoterpene found in the oils of a variety of aromatic plants including lemongrass, verbena, hop, bay, and others. MYR and essential oils containing this terpenoid compound are used in cosmetics, household products, and as flavoring food additives. This study was undertaken to investigate the effects of MYR on fertility and general reproductive performance in the rat. MYR (0, 100, 300 and 500 mg/kg) in peanut oil was given by gavage to male Wistar rats (15 per dose group) for 91 days prior to mating and during the mating period, as well as to females (45 per dose group) continuously for 21 days before mating, during mating and pregnancy, and throughout the period of lactation up to postnatal day 21. On day 21 of pregnancy one-third of the females of each group were submitted to cesarean section. Resorption, implantation, as well as dead and live fetuses were counted. All fetuses were examined for external malformations, weighed, and cleared and stained with Alizarin Red S for skeleton evaluation. The remaining dams were allowed to give birth to their offspring. The progeny was examined at birth and subsequently up to postnatal day 21. Mortality, weight gain and physical signs of postnatal development were evaluated. Except for an increase in liver and kidney weights, no other sign of toxicity was noted in male and female rats exposed to MYR. MYR did not affect the mating index (proportion of females impregnated by males) or the pregnancy index (ratio of pregnant to sperm-positive females). No sign of maternal toxicity and no increase in externally visible malformations were observed at any dose level. Only at the highest dose tested (500 mg/kg) did MYR induce an increase in the resorption rate and a higher frequency of fetal skeleton anomalies. No adverse effect of MYR on postnatal weight gain was noted but days of appearance of primary coat, incisor eruption and eye opening were slightly delayed in the exposed offspring. On the basis of the data presented in this paper the no-observed-adverse-effect level (NOAEL) for toxic effects on fertility and general reproductive performance can be set at 300 mg of ß-myrcene/kg body weight by the oral route.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29234/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALStudyEffectMyrcene.pdfStudyEffectMyrcene.pdfapplication/pdf115221https://www.arca.fiocruz.br/bitstream/icict/29234/2/StudyEffectMyrcene.pdf20ea5f87ca591487e8726bbb78f8fd5bMD52TEXTStudyEffectMyrcene.pdf.txtStudyEffectMyrcene.pdf.txtExtracted texttext/plain35049https://www.arca.fiocruz.br/bitstream/icict/29234/3/StudyEffectMyrcene.pdf.txt9f71e6dd763506ee5693a2f33a867adbMD53icict/292342023-01-12 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dc.title.pt_BR.fl_str_mv Study of the effects of ß-myrcene on rat fertility and general reproductive performance
title Study of the effects of ß-myrcene on rat fertility and general reproductive performance
spellingShingle Study of the effects of ß-myrcene on rat fertility and general reproductive performance
Paumgartten, Francisco José Roma
Monoterpenos
Óleos Voláteis
Fertilidade
Crescimento & Desenvolvimento
ß-Myrcene
Monoterpenes
Essential Oils
Reproductive Toxicity
Fertility
Embryofetal Toxicity
Postnatal Development
Monoterpenes
Oils, Volatile
Growth & Development
Fertility
title_short Study of the effects of ß-myrcene on rat fertility and general reproductive performance
title_full Study of the effects of ß-myrcene on rat fertility and general reproductive performance
title_fullStr Study of the effects of ß-myrcene on rat fertility and general reproductive performance
title_full_unstemmed Study of the effects of ß-myrcene on rat fertility and general reproductive performance
title_sort Study of the effects of ß-myrcene on rat fertility and general reproductive performance
author Paumgartten, Francisco José Roma
author_facet Paumgartten, Francisco José Roma
Carvalho, Rosângela Ribeiro de
Madi, Kalil
Chahoud, Ibrahim
author_role author
author2 Carvalho, Rosângela Ribeiro de
Madi, Kalil
Chahoud, Ibrahim
author2_role author
author
author
dc.contributor.author.fl_str_mv Paumgartten, Francisco José Roma
Carvalho, Rosângela Ribeiro de
Madi, Kalil
Chahoud, Ibrahim
dc.subject.other.pt_BR.fl_str_mv Monoterpenos
Óleos Voláteis
Fertilidade
Crescimento & Desenvolvimento
topic Monoterpenos
Óleos Voláteis
Fertilidade
Crescimento & Desenvolvimento
ß-Myrcene
Monoterpenes
Essential Oils
Reproductive Toxicity
Fertility
Embryofetal Toxicity
Postnatal Development
Monoterpenes
Oils, Volatile
Growth & Development
Fertility
dc.subject.en.pt_BR.fl_str_mv ß-Myrcene
Monoterpenes
Essential Oils
Reproductive Toxicity
Fertility
Embryofetal Toxicity
Postnatal Development
dc.subject.decs.pt_BR.fl_str_mv Monoterpenes
Oils, Volatile
Growth & Development
Fertility
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2018-10-02T14:36:33Z
dc.date.available.fl_str_mv 2018-10-02T14:36:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAUMGARTTEN, Francisco José Roma et al. Study of the effects of ß-myrcene on rat fertility and general reproductive performance. Brazilian Journal of Medical and Biological Research, v. 31, n. 7, p. 955-965, 1998.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29234
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.doi.none.fl_str_mv 10.1590/S0100-879X1998000700012
dc.identifier.eissn.none.fl_str_mv 1414-431X
identifier_str_mv PAUMGARTTEN, Francisco José Roma et al. Study of the effects of ß-myrcene on rat fertility and general reproductive performance. Brazilian Journal of Medical and Biological Research, v. 31, n. 7, p. 955-965, 1998.
0100-879X
10.1590/S0100-879X1998000700012
1414-431X
url https://www.arca.fiocruz.br/handle/icict/29234
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/29234/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/29234/2/StudyEffectMyrcene.pdf
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