Susceptibility loci for pancreatic cancer in the Brazilian population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47140 |
Resumo: | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. |
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Aoki, Mateus NóbregaStein, AngelikaOliveira, Jaqueline Carvalho deChammas, RogerUno, MiyukiMunhoz, Francielle Boçon de AraújoMarin, Anelis MariaCanzian, Federico2021-05-11T20:08:40Z2021-05-11T20:08:40Z2021AOKI, Mateus Nóbrega et al. Susceptibility loci for pancreatic câncer in the Brazilian population. BMC Medical Genomics, v.14, n. 111, p. 1–12, 2021.1755-8794https://www.arca.fiocruz.br/handle/icict/4714010.1186/s12920-021-00956-5porBMCSuscetibilidade GenéticaSNPsPancreatic NeoplasmsCarcinoma, Pancreatic DuctalGenetic Predisposition to DiseaseGenetic Association StudiesPolymorphism, Single NucleotideNeoplasias PancreáticasCarcinoma Ductal PancreáticoPredisposición Genética a la EnfermedadEstudios de Asociación GenéticaPolimorfismo de Nucleótido SimpleTumeurs du pancréasCarcinome du canal pancréatiquePrédisposition génétique à une maladieÉtudes d'associations génétiquesPolymorphisme de nucléotide simpleNeoplasias PancreáticasCarcinoma Ductal PancreáticoPredisposição Genética para DoençaEstudos de Associação GenéticaPolimorfismo de Nucleotídeo ÚnicoSusceptibility loci for pancreatic cancer in the Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Genomic Epidemiology Group. German Cancer Research Center. Heidelberg, Germany.Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.Faculdade de Medicina da Universidade de São Paulo. Instituto do Câncer do Estado de São Paulo. Centro de Investigação Translacional em Oncologia. Departamento de Radiologia e Oncologia, São Paulo, SP, Brasil.Faculdade de Medicina da Universidade de São Paulo. Instituto do Câncer do Estado de São Paulo. Centro de Investigação Translacional em Oncologia. Departamento de Radiologia e Oncologia, São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Genomic Epidemiology Group. German Cancer Research Center. Heidelberg, Germany.Pancreatic adenocarcinoma (PA) is a very aggressive cancer and has one of the poorest prognoses. Usually, the diagnosis is late and resistant to conventional treatment. Environmental and genetic factors contribute to the etiology, such as tobacco and alcohol consumption, chronic pancreatitis, diabetes and obesity. Somatic mutation in pancreatic cancer cells are known and SNP profle by GWAS could access novel genetic risk factors for this disease in diferent population context. Here we describe a SNP panel for Brazilian pancreatic cancer, together with clinical and epidemiological data. Methods: 78 pancreatic adenocarcinoma and 256 non-pancreatic cancer subjects had 25 SNPs genotyped by realtime PCR. Unconditional logistic regression methods were used to assess the main efects on PA risk, using allelic, co-dominant and dominant inheritance models. Results: 9 SNPs were nominally associated with pancreatic adenocarcinoma risk, with 5 of the minor alleles conferring protective efect while 4 related as risk factor. In epidemiological and clinical data, tobacco smoking, diabetes and pancreatitis history were signifcantly related to pancreatic adenocarcinoma risk. Polygenic risk scores computed using the SNPs in the study showed strong associations with PA risk. Conclusion: We could assess for the frst time some SNPs related with PA in Brazilian populations, a result that could be used for genetic screening in risk population such as familial pancreatic cancer, smokers, alcohol users and diabetes patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/47140/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALs12920-021-0095ok.pdfs12920-021-0095ok.pdfapplication/pdf1267317https://www.arca.fiocruz.br/bitstream/icict/47140/2/s12920-021-0095ok.pdfe5b4290ea264dc1bfa689fffc8c6441dMD52TEXTs12920-021-0095ok.pdf.txts12920-021-0095ok.pdf.txtExtracted texttext/plain67795https://www.arca.fiocruz.br/bitstream/icict/47140/3/s12920-021-0095ok.pdf.txt15b274c24eeaf02c0337793df6e3e4ffMD53icict/471402021-05-12 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| dc.title.pt_BR.fl_str_mv |
Susceptibility loci for pancreatic cancer in the Brazilian population |
| title |
Susceptibility loci for pancreatic cancer in the Brazilian population |
| spellingShingle |
Susceptibility loci for pancreatic cancer in the Brazilian population Aoki, Mateus Nóbrega Suscetibilidade Genética SNPs Pancreatic Neoplasms Carcinoma, Pancreatic Ductal Genetic Predisposition to Disease Genetic Association Studies Polymorphism, Single Nucleotide Neoplasias Pancreáticas Carcinoma Ductal Pancreático Predisposición Genética a la Enfermedad Estudios de Asociación Genética Polimorfismo de Nucleótido Simple Tumeurs du pancréas Carcinome du canal pancréatique Prédisposition génétique à une maladie Études d'associations génétiques Polymorphisme de nucléotide simple Neoplasias Pancreáticas Carcinoma Ductal Pancreático Predisposição Genética para Doença Estudos de Associação Genética Polimorfismo de Nucleotídeo Único |
| title_short |
Susceptibility loci for pancreatic cancer in the Brazilian population |
| title_full |
Susceptibility loci for pancreatic cancer in the Brazilian population |
| title_fullStr |
Susceptibility loci for pancreatic cancer in the Brazilian population |
| title_full_unstemmed |
Susceptibility loci for pancreatic cancer in the Brazilian population |
| title_sort |
Susceptibility loci for pancreatic cancer in the Brazilian population |
| author |
Aoki, Mateus Nóbrega |
| author_facet |
Aoki, Mateus Nóbrega Stein, Angelika Oliveira, Jaqueline Carvalho de Chammas, Roger Uno, Miyuki Munhoz, Francielle Boçon de Araújo Marin, Anelis Maria Canzian, Federico |
| author_role |
author |
| author2 |
Stein, Angelika Oliveira, Jaqueline Carvalho de Chammas, Roger Uno, Miyuki Munhoz, Francielle Boçon de Araújo Marin, Anelis Maria Canzian, Federico |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Aoki, Mateus Nóbrega Stein, Angelika Oliveira, Jaqueline Carvalho de Chammas, Roger Uno, Miyuki Munhoz, Francielle Boçon de Araújo Marin, Anelis Maria Canzian, Federico |
| dc.subject.other.pt_BR.fl_str_mv |
Suscetibilidade Genética SNPs |
| topic |
Suscetibilidade Genética SNPs Pancreatic Neoplasms Carcinoma, Pancreatic Ductal Genetic Predisposition to Disease Genetic Association Studies Polymorphism, Single Nucleotide Neoplasias Pancreáticas Carcinoma Ductal Pancreático Predisposición Genética a la Enfermedad Estudios de Asociación Genética Polimorfismo de Nucleótido Simple Tumeurs du pancréas Carcinome du canal pancréatique Prédisposition génétique à une maladie Études d'associations génétiques Polymorphisme de nucléotide simple Neoplasias Pancreáticas Carcinoma Ductal Pancreático Predisposição Genética para Doença Estudos de Associação Genética Polimorfismo de Nucleotídeo Único |
| dc.subject.en.pt_BR.fl_str_mv |
Pancreatic Neoplasms Carcinoma, Pancreatic Ductal Genetic Predisposition to Disease Genetic Association Studies Polymorphism, Single Nucleotide |
| dc.subject.es.pt_BR.fl_str_mv |
Neoplasias Pancreáticas Carcinoma Ductal Pancreático Predisposición Genética a la Enfermedad Estudios de Asociación Genética Polimorfismo de Nucleótido Simple |
| dc.subject.fr.pt_BR.fl_str_mv |
Tumeurs du pancréas Carcinome du canal pancréatique Prédisposition génétique à une maladie Études d'associations génétiques Polymorphisme de nucléotide simple |
| dc.subject.decs.pt_BR.fl_str_mv |
Neoplasias Pancreáticas Carcinoma Ductal Pancreático Predisposição Genética para Doença Estudos de Associação Genética Polimorfismo de Nucleotídeo Único |
| description |
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. |
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2021 |
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2021-05-11T20:08:40Z |
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2021-05-11T20:08:40Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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AOKI, Mateus Nóbrega et al. Susceptibility loci for pancreatic câncer in the Brazilian population. BMC Medical Genomics, v.14, n. 111, p. 1–12, 2021. |
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https://www.arca.fiocruz.br/handle/icict/47140 |
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1755-8794 |
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10.1186/s12920-021-00956-5 |
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AOKI, Mateus Nóbrega et al. Susceptibility loci for pancreatic câncer in the Brazilian population. BMC Medical Genomics, v.14, n. 111, p. 1–12, 2021. 1755-8794 10.1186/s12920-021-00956-5 |
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