Cytokines signatures in short and long-term stable renal transplanted patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.cyto.2013.03.001 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30399 |
Resumo: | 2020-01-01 |
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Mota, Ana Paula LucasVilaça, Sandra SimoneMercês Junior, Fernando Lucas dasPinheiro, Melina de BarrosCarvalho, Andréa Teixeira deSilveira, Amanda Cardoso OliveiraMartins Filho, Olindo AssisGomes, Karina BragaDusse, Luci Maria2018-12-05T15:51:14Z2018-12-05T15:51:14Z2013MOTA, Ana Paula Lucas et al. Cytokines signatures in short and long-term stable renal transplanted patients. Cytokine, v. 62, n. 2, p. 302-309, 20131043-4666https://www.arca.fiocruz.br/handle/icict/3039910.1016/j.cyto.2013.03.001engElsevier Science Ltdtransplante renalcitocinasFunção de enxerto estávelRenal transplantationCytokinesStable graft functionCytokines signatures in short and long-term stable renal transplanted patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Hospital Felicio Rocho. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Nefrologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Fundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Fundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Fundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Despite the evidences showing the relevance of regulatory immune-mediated mechanisms to guarantee the stable graft function in renal transplanted patients, studies focusing on the immune response observed over a long-term period after renal transplantation are still limited. Several efforts have been done to establish novel biomarkers with relevant predictive values that could be used as prognostic laboratorial tools to monitor the complex network triggered through time after kidney transplantation. In this study, we have evaluated the pro-inflammatory and regulatory patterns of plasma cytokines in a group of 120 renal transplanted patients with stable graft function ranging from 1 to 160 months. Our data demonstrated an overall predominance of regulatory cytokines short-term after renal transplantation (1-24 months) with peaks of IL-4, IL-5 and IL-10. Moreover, a slight peak of TNF-α was observed 25-60 months after renal transplantation. Following a gap of stable cytokine profile (61-120 months), peaks of pro-inflammatory cytokines IL-8, IL-6, IL1β, TNF-α and IL-12 were observed later on (>120 months) after renal transplantation. Additionally, the categorical analysis of "low" or "high" cytokine producers re-enforce the occurrence of an overall regulatory status early-after stable renal graft function with a predominant pro-inflammatory pattern later on long-term renal transplantation. Taken together, our data suggest that IL-5 is a good biomarker associated with short-term stable renal function, whereas IL-12 seems to be a relevant pro-inflammatory element in long-term renal transplanted patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30399/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCytokines signatures in short.pdfCytokines signatures in short.pdfapplication/pdf4474254https://www.arca.fiocruz.br/bitstream/icict/30399/2/Cytokines%20signatures%20in%20short.pdfbec1801ce9f8bf43c19fbd0fa597f372MD52TEXTCytokines signatures in short.pdf.txtCytokines signatures in short.pdf.txtExtracted texttext/plain201https://www.arca.fiocruz.br/bitstream/icict/30399/3/Cytokines%20signatures%20in%20short.pdf.txt5dfac42f59b966ae141974a02a7dfccfMD53icict/303992021-03-24 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| dc.title.pt_BR.fl_str_mv |
Cytokines signatures in short and long-term stable renal transplanted patients |
| title |
Cytokines signatures in short and long-term stable renal transplanted patients |
| spellingShingle |
Cytokines signatures in short and long-term stable renal transplanted patients Mota, Ana Paula Lucas transplante renal citocinas Função de enxerto estável Renal transplantation Cytokines Stable graft function |
| title_short |
Cytokines signatures in short and long-term stable renal transplanted patients |
| title_full |
Cytokines signatures in short and long-term stable renal transplanted patients |
| title_fullStr |
Cytokines signatures in short and long-term stable renal transplanted patients |
| title_full_unstemmed |
Cytokines signatures in short and long-term stable renal transplanted patients |
| title_sort |
Cytokines signatures in short and long-term stable renal transplanted patients |
| author |
Mota, Ana Paula Lucas |
| author_facet |
Mota, Ana Paula Lucas Vilaça, Sandra Simone Mercês Junior, Fernando Lucas das Pinheiro, Melina de Barros Carvalho, Andréa Teixeira de Silveira, Amanda Cardoso Oliveira Martins Filho, Olindo Assis Gomes, Karina Braga Dusse, Luci Maria |
| author_role |
author |
| author2 |
Vilaça, Sandra Simone Mercês Junior, Fernando Lucas das Pinheiro, Melina de Barros Carvalho, Andréa Teixeira de Silveira, Amanda Cardoso Oliveira Martins Filho, Olindo Assis Gomes, Karina Braga Dusse, Luci Maria |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mota, Ana Paula Lucas Vilaça, Sandra Simone Mercês Junior, Fernando Lucas das Pinheiro, Melina de Barros Carvalho, Andréa Teixeira de Silveira, Amanda Cardoso Oliveira Martins Filho, Olindo Assis Gomes, Karina Braga Dusse, Luci Maria |
| dc.subject.other.pt_BR.fl_str_mv |
transplante renal citocinas Função de enxerto estável |
| topic |
transplante renal citocinas Função de enxerto estável Renal transplantation Cytokines Stable graft function |
| dc.subject.en.pt_BR.fl_str_mv |
Renal transplantation Cytokines Stable graft function |
| description |
2020-01-01 |
| publishDate |
2013 |
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2013 |
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2018-12-05T15:51:14Z |
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2018-12-05T15:51:14Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MOTA, Ana Paula Lucas et al. Cytokines signatures in short and long-term stable renal transplanted patients. Cytokine, v. 62, n. 2, p. 302-309, 2013 |
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https://www.arca.fiocruz.br/handle/icict/30399 |
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1043-4666 |
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10.1016/j.cyto.2013.03.001 |
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MOTA, Ana Paula Lucas et al. Cytokines signatures in short and long-term stable renal transplanted patients. Cytokine, v. 62, n. 2, p. 302-309, 2013 1043-4666 10.1016/j.cyto.2013.03.001 |
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Elsevier Science Ltd |
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