The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study

Detalhes bibliográficos
Autor(a) principal: Alexandre, Márcia Almeida Araújo
Data de Publicação: 2015
Outros Autores: Benzecry, Silvana Gomes, Siqueira, Andre Machado, Vitor-Silva, Sheila, Melo, Gisely Cardoso, Monteiro, Wuelton Marcelo, Leite, Heitor Pons, Lacerda, Marcus Vinícius Guimarães, Alecrim, Maria das Graças Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31852
Resumo: Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil.
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spelling Alexandre, Márcia Almeida AraújoBenzecry, Silvana GomesSiqueira, Andre MachadoVitor-Silva, SheilaMelo, Gisely CardosoMonteiro, Wuelton MarceloLeite, Heitor PonsLacerda, Marcus Vinícius GuimarãesAlecrim, Maria das Graças Costa2019-02-25T12:26:22Z2019-02-25T12:26:22Z2015ALEXANDRE, Márcia Almeida Araújo et al. The association between nutritional status and malaria in children from a rural community in the Amazonian Region: a longitudinal study. Plos Neglected Tropical Diseases, p. 1-15, Apr. 2015.1935-2735https://www.arca.fiocruz.br/handle/icict/3185210.1371/journal.pntd.00037431935-2735engPublic Library of ScienceThe association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil / Federal University of São Paulo. Department of Pediatrics. Discipline of Nutrition and Metabolism. São Paulo, SP, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil.Federal University of São Paulo. Department of Pediatrics. Discipline of Nutrition and Metabolism. São Paulo, SP, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil.Background: The relationship between malaria and undernutrition is controversial and complex. Synergistic associations between malnutrition and malaria morbidity and mortality have been suggested, as well as undernutrition being protective against infection, while other studies found no association. We sought to evaluate the relationship between the number of malaria episodes and nutritional statuses in a cohort of children below 15 years of age living in a rural community in the Brazilian Amazon. Methodology/Principal Findings: Following a baseline survey of clinical, malaria and nutritional assessment including anthropometry measurements and hemoglobin concentration, 202 children ranging from 1 month to 14 years of age were followed for one year through passive case detection for malaria episodes. After follow-up, all children were assessed again in order to detect changes in nutritional indicators associated with malaria infection. We also examined the risk of presenting malaria episodes during follow-up according to presence of stunting at baseline. Children who suffered malaria episodes during follow-up presented worse anthropometric parameters values during this period. The main change was a reduction of the linear growth velocity, associated with both the number of episodes and how close the last or only malaria episode and the second anthropometric assessment were. Changes were also observed for indices associated with chronic changes, such as weight-for-age and BMI-for-age, which conversely, were more frequently observed in children with the last or only episode occurring between 6 and 12 months preceding the second nutritional assessment survey. Children with inadequate height-for-age at baseline (Z-score < -2) presented lower risk of suffering malaria episodes during follow-up as assessed by both the log-rank test (p =0.057) and the multivariable Cox-proportional hazards regression (Hazard Ratio = 0.31, 95%CI [0.10; 0.99] p=0.049). Conclusions: Malaria was associated with impaired nutritional status amongst children in an endemic area of the Western Brazilian Amazon where P. vivax predominates. Our data all supports that the association presents differential effects for each age group, suggesting distinct pathophysiology pathways. We were also able to demonstrate that undernourishment at baseline was protective to malaria during follow-up. These findings support an intriguing interaction between these conditions in the rural Amazon and the need for a more integrative approach by health systems in endemic areas.MalariaChildrenUndernutritionRural communityAmazonian RegionBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31852/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Alexandre_Márcia_etal_INI_2015.pdfve_Alexandre_Márcia_etal_INI_2015.pdfapplication/pdf359647https://www.arca.fiocruz.br/bitstream/icict/31852/2/ve_Alexandre_M%c3%a1rcia_etal_INI_2015.pdf3d22847c0fdd3052c98b1aebe0946cd2MD52TEXTve_Alexandre_Márcia_etal_INI_2015.pdf.txtve_Alexandre_Márcia_etal_INI_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
title The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
spellingShingle The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
Alexandre, Márcia Almeida Araújo
Malaria
Children
Undernutrition
Rural community
Amazonian Region
Brazil
title_short The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
title_full The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
title_fullStr The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
title_full_unstemmed The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
title_sort The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study
author Alexandre, Márcia Almeida Araújo
author_facet Alexandre, Márcia Almeida Araújo
Benzecry, Silvana Gomes
Siqueira, Andre Machado
Vitor-Silva, Sheila
Melo, Gisely Cardoso
Monteiro, Wuelton Marcelo
Leite, Heitor Pons
Lacerda, Marcus Vinícius Guimarães
Alecrim, Maria das Graças Costa
author_role author
author2 Benzecry, Silvana Gomes
Siqueira, Andre Machado
Vitor-Silva, Sheila
Melo, Gisely Cardoso
Monteiro, Wuelton Marcelo
Leite, Heitor Pons
Lacerda, Marcus Vinícius Guimarães
Alecrim, Maria das Graças Costa
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alexandre, Márcia Almeida Araújo
Benzecry, Silvana Gomes
Siqueira, Andre Machado
Vitor-Silva, Sheila
Melo, Gisely Cardoso
Monteiro, Wuelton Marcelo
Leite, Heitor Pons
Lacerda, Marcus Vinícius Guimarães
Alecrim, Maria das Graças Costa
dc.subject.en.pt_BR.fl_str_mv Malaria
Children
Undernutrition
Rural community
Amazonian Region
Brazil
topic Malaria
Children
Undernutrition
Rural community
Amazonian Region
Brazil
description Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, Amazonas, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-02-25T12:26:22Z
dc.date.available.fl_str_mv 2019-02-25T12:26:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ALEXANDRE, Márcia Almeida Araújo et al. The association between nutritional status and malaria in children from a rural community in the Amazonian Region: a longitudinal study. Plos Neglected Tropical Diseases, p. 1-15, Apr. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31852
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0003743
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv ALEXANDRE, Márcia Almeida Araújo et al. The association between nutritional status and malaria in children from a rural community in the Amazonian Region: a longitudinal study. Plos Neglected Tropical Diseases, p. 1-15, Apr. 2015.
1935-2735
10.1371/journal.pntd.0003743
url https://www.arca.fiocruz.br/handle/icict/31852
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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