Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31217 |
Resumo: | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Morrot, AlexandreFonseca, Leonardo Marques daSalustiano, Eduardo J.Gentile, Luciana BoffoniConde, LucianaFilardy, Alessandra AlmeidaFranklim, Tatiany NunesCosta, Kelly Monteiro daLima, Celio Geraldo Freire deLima, Leonardo Freire de2019-01-22T13:37:20Z2019-01-22T13:37:20Z2018MORROT, Alexandre; et al. Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses. Frontiers im Oncology, v.8, Article 81, 10p, Mar. 2018.2234-943Xhttps://www.arca.fiocruz.br/handle/icict/3121710.3389/fonc.2018.00081engFrontiers MediaCâncerMetabolismoCitocinasLactatoEvasão da Resposta ImuneCancerMetabolismLactateImmune evasionCytokinesEvasão da Resposta ImuneMetabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responsesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.The tumor microenvironment (TME) is composed by cellular and non-cellular components. Examples include the following: (i) bone marrow-derived inflammatory cells, (ii) fibroblasts, (iii) blood vessels, (iv) immune cells, and (v) extracellular matrix components. In most cases, this combination of components may result in an inhospitable environment, in which a significant retrenchment in nutrients and oxygen considerably disturbs cell metabolism. Cancer cells are characterized by an enhanced uptake and utilization of glucose, a phenomenon described by Otto Warburg over 90 years ago. One of the main products of this reprogrammed cell metabolism is lactate. “Lactagenic” or lactate-producing cancer cells are characterized by their immunomodulatory properties, since lactate, the end product of the aerobic glycolysis, besides acting as an inducer of cellular signaling phenomena to influence cellular fate, might also play a role as an immunosuppressive metabolite. Over the last 10 years, it has been well accepted that in the TME, the lactate secreted by transformed cells is able to compromise the function and/or assembly of an effective immune response against tumors. Herein, we will discuss recent advances regarding the deleterious effect of high concentrations of lactate on the tumor-infiltrating immune cells, which might characterize an innovative way of understanding the tumor-immune privilege.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31217/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalexandre_morrot_etal_IOC_2018.pdfalexandre_morrot_etal_IOC_2018.pdfapplication/pdf947912https://www.arca.fiocruz.br/bitstream/icict/31217/2/alexandre_morrot_etal_IOC_2018.pdf30d1bfb802eefd37d84a2ec58eda44d7MD52TEXTalexandre_morrot_etal_IOC_2018.pdf.txtalexandre_morrot_etal_IOC_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses |
| title |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses |
| spellingShingle |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses Morrot, Alexandre Câncer Metabolismo Citocinas Lactato Evasão da Resposta Imune Cancer Metabolism Lactate Immune evasion Cytokines Evasão da Resposta Imune |
| title_short |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses |
| title_full |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses |
| title_fullStr |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses |
| title_full_unstemmed |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses |
| title_sort |
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses |
| author |
Morrot, Alexandre |
| author_facet |
Morrot, Alexandre Fonseca, Leonardo Marques da Salustiano, Eduardo J. Gentile, Luciana Boffoni Conde, Luciana Filardy, Alessandra Almeida Franklim, Tatiany Nunes Costa, Kelly Monteiro da Lima, Celio Geraldo Freire de Lima, Leonardo Freire de |
| author_role |
author |
| author2 |
Fonseca, Leonardo Marques da Salustiano, Eduardo J. Gentile, Luciana Boffoni Conde, Luciana Filardy, Alessandra Almeida Franklim, Tatiany Nunes Costa, Kelly Monteiro da Lima, Celio Geraldo Freire de Lima, Leonardo Freire de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Morrot, Alexandre Fonseca, Leonardo Marques da Salustiano, Eduardo J. Gentile, Luciana Boffoni Conde, Luciana Filardy, Alessandra Almeida Franklim, Tatiany Nunes Costa, Kelly Monteiro da Lima, Celio Geraldo Freire de Lima, Leonardo Freire de |
| dc.subject.other.pt_BR.fl_str_mv |
Câncer Metabolismo Citocinas Lactato Evasão da Resposta Imune |
| topic |
Câncer Metabolismo Citocinas Lactato Evasão da Resposta Imune Cancer Metabolism Lactate Immune evasion Cytokines Evasão da Resposta Imune |
| dc.subject.en.pt_BR.fl_str_mv |
Cancer Metabolism Lactate Immune evasion Cytokines |
| dc.subject.decs.pt_BR.fl_str_mv |
Evasão da Resposta Imune |
| description |
Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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2018 |
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2018 |
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2019-01-22T13:37:20Z |
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2019-01-22T13:37:20Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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MORROT, Alexandre; et al. Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses. Frontiers im Oncology, v.8, Article 81, 10p, Mar. 2018. |
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https://www.arca.fiocruz.br/handle/icict/31217 |
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2234-943X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fonc.2018.00081 |
| identifier_str_mv |
MORROT, Alexandre; et al. Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses. Frontiers im Oncology, v.8, Article 81, 10p, Mar. 2018. 2234-943X 10.3389/fonc.2018.00081 |
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