Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil

Detalhes bibliográficos
Autor(a) principal: Benzaken, Adele Schwartz
Data de Publicação: 2008
Outros Autores: Sabidó, Meritxell, Pedroza, Valderiza, Vasquez, Felicien, Araújo, Adauto José Goncalves de, Peeling, Rosanna W, Maynaud, Phillippe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35060
Resumo: Fundação Alfredo da Matta. Manaus, AM, Brasil.
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spelling Benzaken, Adele SchwartzSabidó, MeritxellPedroza, ValderizaVasquez, FelicienAraújo, Adauto José Goncalves dePeeling, Rosanna WMaynaud, Phillippe2019-08-26T13:12:58Z2019-08-26T13:12:58Z2008BENZAKEN, Adele Schwartz et al. Field evaluation of the performance and testing costs of a rapid point-of-care test for syphilis in a red-light district of Manaus, Brazil. Sexually Transmitted Infections, v. 84, n. 4, p. 1-6, 2008.1368-4973https://www.arca.fiocruz.br/handle/icict/3506010.1136/sti.2008.0304111472-3263engBritish Association of Sexual Health and HIVField evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Alfredo da Matta. Manaus, AM, Brasil.London School of Hygiene & Tropical Medicine. London, UK.Fundação Alfredo da Matta. Manaus, AM, Brasil.Fundação Alfredo da Matta. Manaus, AM, Brasil.Fundação Alfredo da Matta. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.World Health Organization. Geneva, Switzerland.OBJECTIVES: To assess the performance, usefulness and cost of a rapid treponemal antibody assay (VisiTect Syphilis) to detect syphilis in high risk populations. METHODS: People who attended STI clinics in Manaus, Brazil, were screened for syphilis using the fluorescent treponemal antibody absorption (FTA-Abs) test and a non-treponemal test (Venereal Diseases Research Laboratory (VDRL)), and for HIV. Finger prick blood samples were tested with VisiTect Syphilis. The rapid test was evaluated against the reference FTA-Abs and for its usefulness in detecting active syphilis (FTA-Abs and VDRL positive). Operational performance was assessed through providers' and patients' interviews. An economic evaluation was conducted from the provider's perspective. RESULTS: 510 patients (60% men) were enrolled, of whom 13 (2.5%) were HIV-1 seropositive. Syphilis prevalence (FTA-Abs) was 18% and active syphilis prevalence was 7.5%. 11% (57/506) of samples were positive by VisiTect. The sensitivity, specificity, positive and negative predictive values of VisiTect Syphilis were 57% (95% CI 45.8 to 66.7), 99% (95% CI 97.0 to 99.6), 91% (95% CI 80.0 to 96.7) and 91% (95% CI 88.0 to 93.5), respectively. VisiTect Syphilis identified 79% (30/38) of active syphilis cases. The cost per case of syphilis was $16.8 for VDRL, $33.2 for low cost and $56.3 for high cost VisiTect Syphilis; the cost per case of active syphilis was $21.3, $57.5 and $97.6, respectively. Patients identified finger prick pain and preference for venous blood collection as minor barriers to test use. CONCLUSION: VisiTect Syphilis had low sensitivity in field use and was less cost effective than conventional VDRL. However, rapid and correct identification of a high proportion of active syphilis cases combined with operational characteristics suggest a role in high risk populations.Syphilisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35060/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALFieldEvaluation.pdfapplication/pdf177639https://www.arca.fiocruz.br/bitstream/icict/35060/2/FieldEvaluation.pdf417e97b6da6816379d956c2c88c54fefMD52TEXTFieldEvaluation.pdf.txtFieldEvaluation.pdf.txtExtracted texttext/plain32585https://www.arca.fiocruz.br/bitstream/icict/35060/3/FieldEvaluation.pdf.txt0d1c7323f99eb3561cb001d59d1a3ee4MD53icict/350602019-08-27 20:45:40.397oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-08-27T23:45:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
title Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
spellingShingle Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
Benzaken, Adele Schwartz
Syphilis
title_short Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
title_full Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
title_fullStr Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
title_full_unstemmed Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
title_sort Field evaluation of the performance and testing costs of a rapid point-of-care test for syphillis in a red-light district of Manaus, Brazil
author Benzaken, Adele Schwartz
author_facet Benzaken, Adele Schwartz
Sabidó, Meritxell
Pedroza, Valderiza
Vasquez, Felicien
Araújo, Adauto José Goncalves de
Peeling, Rosanna W
Maynaud, Phillippe
author_role author
author2 Sabidó, Meritxell
Pedroza, Valderiza
Vasquez, Felicien
Araújo, Adauto José Goncalves de
Peeling, Rosanna W
Maynaud, Phillippe
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Benzaken, Adele Schwartz
Sabidó, Meritxell
Pedroza, Valderiza
Vasquez, Felicien
Araújo, Adauto José Goncalves de
Peeling, Rosanna W
Maynaud, Phillippe
dc.subject.en.pt_BR.fl_str_mv Syphilis
topic Syphilis
description Fundação Alfredo da Matta. Manaus, AM, Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2019-08-26T13:12:58Z
dc.date.available.fl_str_mv 2019-08-26T13:12:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BENZAKEN, Adele Schwartz et al. Field evaluation of the performance and testing costs of a rapid point-of-care test for syphilis in a red-light district of Manaus, Brazil. Sexually Transmitted Infections, v. 84, n. 4, p. 1-6, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35060
dc.identifier.issn.pt_BR.fl_str_mv 1368-4973
dc.identifier.doi.none.fl_str_mv 10.1136/sti.2008.030411
dc.identifier.eissn.none.fl_str_mv 1472-3263
identifier_str_mv BENZAKEN, Adele Schwartz et al. Field evaluation of the performance and testing costs of a rapid point-of-care test for syphilis in a red-light district of Manaus, Brazil. Sexually Transmitted Infections, v. 84, n. 4, p. 1-6, 2008.
1368-4973
10.1136/sti.2008.030411
1472-3263
url https://www.arca.fiocruz.br/handle/icict/35060
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv British Association of Sexual Health and HIV
publisher.none.fl_str_mv British Association of Sexual Health and HIV
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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institution FIOCRUZ
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