Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27258 |
Resumo: | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Souza, Robson da Paixão deCardoso, Luciana SantosLopes, Giuseppe Tittoni VarelaAlmeida, Maria Cecília FOliveira, Ricardo RiccioAlcântara, Leda MariaCarvalho Filho, Edgar MarcelinoAraujo, Maria Ilma Andrade Santos2018-07-03T19:19:41Z2018-07-03T19:19:41Z2012SOUZA, R. P. et al. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research, Article ID 394981, 2012.2090-0023https://www.arca.fiocruz.br/handle/icict/2725810.1155/2012/394981Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Fundação de Amparo à Pesquisa do Estado da (Bahia FAPESB) for the financial support. E. Carvalho and M. I. Araujo are investigators supported by The Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). This work was supported by the Brazilian National Research Council (CNPq) Universal (482113/2010-3).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciencias da Vida. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilPeriportal fibrosis in schistosomiasis has been associated to the host immune response to parasite antigens. We evaluated the immune response in S. mansoni infected individuals with different degrees of periportal fibrosis. Cytokine and chemokines were measured in serum and in supernatants of PBMC cultures stimulated with the soluble adult worm (SWAP) or egg (SEA) antigens, using a sandwich ELISA. The levels of IL-5 in response to SEA were higher in individuals with moderate to severe fibrosis (310.9 pg/mL) compared to individuals without fibrosis (36.8 pg/mL; P = 0.0418). There was also a higher production of TNF-α in cultures stimulated with SWAP in patients with insipient fibrosis (1446 pg/mL) compared to those without fibrosis (756.1 pg/mL; P = 0.0319). The serum levels of IL-13 and MIP-1α were higher in subjects without fibrosis than in those with moderate to severe fibrosis. However a positive association between serum levels of IL-13, TNF-α, MIP-1α, and RANTES and S. mansoni parasite burden was found. From these data we conclude that IL-5 and TNF-α may participate in liver pathology in schistosomiasis. The positive association between IL-13, TNF-α, MIP-1α, and RANTES with parasite burden, however, might predict the development of liver pathology.engHindawi Publishing CorporationSchistosoma mansoniFibroseInfecçãoHumanosCitocinasSchistosoma mansoniFibrosisInfectionHumansCytokineCytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27258/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza RP Cytokine and Chemokine Profile ....pdfSouza RP Cytokine and Chemokine Profile 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| dc.title.pt_BR.fl_str_mv |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection |
| title |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection |
| spellingShingle |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection Souza, Robson da Paixão de Schistosoma mansoni Fibrose Infecção Humanos Citocinas Schistosoma mansoni Fibrosis Infection Humans Cytokine |
| title_short |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection |
| title_full |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection |
| title_fullStr |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection |
| title_full_unstemmed |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection |
| title_sort |
Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection |
| author |
Souza, Robson da Paixão de |
| author_facet |
Souza, Robson da Paixão de Cardoso, Luciana Santos Lopes, Giuseppe Tittoni Varela Almeida, Maria Cecília F Oliveira, Ricardo Riccio Alcântara, Leda Maria Carvalho Filho, Edgar Marcelino Araujo, Maria Ilma Andrade Santos |
| author_role |
author |
| author2 |
Cardoso, Luciana Santos Lopes, Giuseppe Tittoni Varela Almeida, Maria Cecília F Oliveira, Ricardo Riccio Alcântara, Leda Maria Carvalho Filho, Edgar Marcelino Araujo, Maria Ilma Andrade Santos |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Robson da Paixão de Cardoso, Luciana Santos Lopes, Giuseppe Tittoni Varela Almeida, Maria Cecília F Oliveira, Ricardo Riccio Alcântara, Leda Maria Carvalho Filho, Edgar Marcelino Araujo, Maria Ilma Andrade Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Fibrose Infecção Humanos Citocinas |
| topic |
Schistosoma mansoni Fibrose Infecção Humanos Citocinas Schistosoma mansoni Fibrosis Infection Humans Cytokine |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Fibrosis Infection Humans Cytokine |
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Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2012 |
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2012 |
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2018-07-03T19:19:41Z |
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2018-07-03T19:19:41Z |
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SOUZA, R. P. et al. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research, Article ID 394981, 2012. |
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https://www.arca.fiocruz.br/handle/icict/27258 |
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2090-0023 |
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10.1155/2012/394981 |
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SOUZA, R. P. et al. Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection. Journal of Parasitology Research, Article ID 394981, 2012. 2090-0023 10.1155/2012/394981 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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