Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela

Detalhes bibliográficos
Autor(a) principal: Marcano, Teodardo José
Data de Publicação: 2004
Outros Autores: Morgado, Anastácio, Tosta, Carlos Eduardo, Coura, José Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33996
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ. Brasil.
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spelling Marcano, Teodardo JoséMorgado, AnastácioTosta, Carlos EduardoCoura, José Rodrigues2019-07-11T16:34:13Z2019-07-11T16:34:13Z2004MARCANO, Teodardo José et al. Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 369-376, June 2004.0074-0276https://www.arca.fiocruz.br/handle/icict/3399610.1590/S0074-027620040004000051678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzMaláriaAmeríndios YanomamiImunidadeMorbilidadeRegião AmazônicaMalariaMorbidityImmunityYanomami AmerindiansAmazon regionBrazilCross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuelainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ. Brasil.Universidade de Brasília. Faculdade de Ciências da Saúde. Departamento de Patologia. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ. Brasil.It is well established that immunity to malaria is short-lived and is maintained by the continuous contact with the parasite. We now show that the stable transmission of malaria in Yanomami Amerindian communities maintains a degree of immunity in the exposed population capable to reduce prevalence and morbidity of malaria. We examined 508 Yanomami Amerindians living along Orinoco (407) and Mucajaí (101) rivers, on the Venezuelan and Brazilian Amazon region, respectively. At Orinoco villages, malaria was hyperendemic and presented stable transmission, while at Mucajaí villages it was mesoendemic and showed unstable transmission. The frequency of Plasmodium vivax and P. falciparum was roughly comparable in Venezuelan and Brazilian communities. Malaria presented different profiles at Orinoco and Mucajaí villages. In the former communities, malaria showed a lower prevalence (16% x 40.6%), particularly among those over 10 years old (5.2% x 34.8%), a higher frequency of asymptomatic cases (38.5% x 4.9%), and a lower frequency of cases of severe malaria (9.2% x 36.5%). Orinoco villagers also showed a higher reactivity of the immune system, measured by the frequency of splenomegaly (72.4% x 29.7%) and by the splenic index (71.4% over level 1 x 28.6), and higher prevalence (91.1% x 72.1%) and mean titer (1243 x 62) of antiplasmodial IgG antibodies, as well as a higher prevalence (77.4% x 24.7%) and mean titer (120 x 35) of antiplasmodial IgM antibodies. Our findings show that in isolated Yanomami communities the stability of malaria transmission, and the consequent continuous activation of the immune system of the exposed population, leads to the reduction of malaria prevalence and morbidity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33996/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarlosETosta_JRCoura_etal_IOC_2004.pdfCarlosETosta_JRCoura_etal_IOC_2004.pdfapplication/pdf57347https://www.arca.fiocruz.br/bitstream/icict/33996/2/CarlosETosta_JRCoura_etal_IOC_2004.pdf6773db1b795e78057846cd5998057742MD52TEXTCarlosETosta_JRCoura_etal_IOC_2004.pdf.txtCarlosETosta_JRCoura_etal_IOC_2004.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
title Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
spellingShingle Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
Marcano, Teodardo José
Malária
Ameríndios Yanomami
Imunidade
Morbilidade
Região Amazônica
Malaria
Morbidity
Immunity
Yanomami Amerindians
Amazon region
Brazil
title_short Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
title_full Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
title_fullStr Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
title_full_unstemmed Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
title_sort Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela
author Marcano, Teodardo José
author_facet Marcano, Teodardo José
Morgado, Anastácio
Tosta, Carlos Eduardo
Coura, José Rodrigues
author_role author
author2 Morgado, Anastácio
Tosta, Carlos Eduardo
Coura, José Rodrigues
author2_role author
author
author
dc.contributor.author.fl_str_mv Marcano, Teodardo José
Morgado, Anastácio
Tosta, Carlos Eduardo
Coura, José Rodrigues
dc.subject.other.pt_BR.fl_str_mv Malária
Ameríndios Yanomami
Imunidade
Morbilidade
Região Amazônica
topic Malária
Ameríndios Yanomami
Imunidade
Morbilidade
Região Amazônica
Malaria
Morbidity
Immunity
Yanomami Amerindians
Amazon region
Brazil
dc.subject.en.pt_BR.fl_str_mv Malaria
Morbidity
Immunity
Yanomami Amerindians
Amazon region
Brazil
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ. Brasil.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2019-07-11T16:34:13Z
dc.date.available.fl_str_mv 2019-07-11T16:34:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARCANO, Teodardo José et al. Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 369-376, June 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33996
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762004000400005
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MARCANO, Teodardo José et al. Cross-sectional Study Defines Difference in Malaria Morbidity in Two Yanomami Communities on Amazonian Boundary between Brazil and Venezuela. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 369-376, June 2004.
0074-0276
10.1590/S0074-02762004000400005
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33996
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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