Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential

Detalhes bibliográficos
Autor(a) principal: Soares, Giselle Apicela
Data de Publicação: 2010
Outros Autores: Oliveira, Renata Barbosa de, Andrade, Saulo Fernandes de, Alves, Ricardo José, Zani, Carlos Leomar, Fagundes, Elaine Maria de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5880
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil
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spelling Soares, Giselle ApicelaOliveira, Renata Barbosa deAndrade, Saulo Fernandes deAlves, Ricardo JoséZani, Carlos LeomarFagundes, Elaine Maria de Souza2012-11-27T16:32:59Z2012-11-27T16:32:59Z2010SOARES, Giselle Apicela et al. Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential. Molecules 2010, 15, 12-26;1420-3049https://www.arca.fiocruz.br/handle/icict/588010.3390/molecules15010012engSynthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potentialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, BrazilIn our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.carbohydratesfuran derivativescytotoxic activityanti-tumorapoptosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL113.2010.pdf113.2010.pdfapplication/pdf398564https://www.arca.fiocruz.br/bitstream/icict/5880/1/113.2010.pdf455cf12adcdd1d63f79b59cb3f77d4adMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5880/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXT113.2010.pdf.txt113.2010.pdf.txtExtracted texttext/plain39578https://www.arca.fiocruz.br/bitstream/icict/5880/5/113.2010.pdf.txtef8b6f766927289c62b857e02a538c9cMD55THUMBNAIL113.2010.pdf.jpg113.2010.pdf.jpgGenerated Thumbnailimage/jpeg2275https://www.arca.fiocruz.br/bitstream/icict/5880/4/113.2010.pdf.jpgb24a5d7ac6f2b393808f6037de363934MD54icict/58802018-04-25 12:54:34.846oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-25T15:54:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
spellingShingle Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
Soares, Giselle Apicela
carbohydrates
furan derivatives
cytotoxic activity
anti-tumor
apoptosis
title_short Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_full Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_fullStr Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_full_unstemmed Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_sort Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
author Soares, Giselle Apicela
author_facet Soares, Giselle Apicela
Oliveira, Renata Barbosa de
Andrade, Saulo Fernandes de
Alves, Ricardo José
Zani, Carlos Leomar
Fagundes, Elaine Maria de Souza
author_role author
author2 Oliveira, Renata Barbosa de
Andrade, Saulo Fernandes de
Alves, Ricardo José
Zani, Carlos Leomar
Fagundes, Elaine Maria de Souza
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Giselle Apicela
Oliveira, Renata Barbosa de
Andrade, Saulo Fernandes de
Alves, Ricardo José
Zani, Carlos Leomar
Fagundes, Elaine Maria de Souza
dc.subject.en.pt_BR.fl_str_mv carbohydrates
furan derivatives
cytotoxic activity
anti-tumor
apoptosis
topic carbohydrates
furan derivatives
cytotoxic activity
anti-tumor
apoptosis
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-11-27T16:32:59Z
dc.date.available.fl_str_mv 2012-11-27T16:32:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Giselle Apicela et al. Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential. Molecules 2010, 15, 12-26;
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5880
dc.identifier.issn.none.fl_str_mv 1420-3049
dc.identifier.doi.none.fl_str_mv 10.3390/molecules15010012
identifier_str_mv SOARES, Giselle Apicela et al. Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential. Molecules 2010, 15, 12-26;
1420-3049
10.3390/molecules15010012
url https://www.arca.fiocruz.br/handle/icict/5880
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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