Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?

Detalhes bibliográficos
Autor(a) principal: Hasslocher-Moreno, Alejandro Marcel
Data de Publicação: 2021
Outros Autores: Georg, Ingebourg, Sangenis, Luiz H. C., Mediano, Mauro F. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50516
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Hasslocher-Moreno, Alejandro MarcelGeorg, IngebourgSangenis, Luiz H. C.Mediano, Mauro F. F.2021-12-22T00:08:56Z2021-12-22T00:08:56Z2021HASSLOCHER-MORENO, Alejandro M. et al. Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center? Microbes, Infection and Chemotherapy, v. 1, e1236, p. 1-3, 20212789-4274https://www.arca.fiocruz.br/handle/icict/5051610.54034/mic.e1236engSensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Introduction: Chagas disease (CD) is a neglected tropical disease. In the chronic phase of CD, the diagnosis is essentially serologic. Conventional reactions are currently in use. More recently, the use of rapid diagnostic testing (RDT) is indicated when conventional techniques are not available. Objective: To evaluate the sensitivity and specificity of RDTs for chronic CD diagnosis. Methodology: Individuals under suspicion of CD were evaluated using ELISA, Chemiluminescence (ChLIA) and RDT tests. Results: The RDT showed 95.1% sensitivity and 96.7% specificity, respectively. Conclusion: The findings of the present study showed that RDT used in the diagnosis of CD at a referral center in Brazil were not able to detect all CD cases when compared to Elisa and ChLIA.Chagas diseaseRapid testELISAChemoluminescenceSensitivitySpecificityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50516/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALSensitivity_Alejandro_Moreno_etal_INI_2021.pdfSensitivity_Alejandro_Moreno_etal_INI_2021.pdfapplication/pdf1611139https://www.arca.fiocruz.br/bitstream/icict/50516/2/Sensitivity_Alejandro_Moreno_etal_INI_2021.pdfc7f5c3b5ff8b42314af10d24b51a6614MD52icict/505162023-03-08 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dc.title.pt_BR.fl_str_mv Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
title Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
spellingShingle Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
Hasslocher-Moreno, Alejandro Marcel
Chagas disease
Rapid test
ELISA
Chemoluminescence
Sensitivity
Specificity
title_short Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
title_full Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
title_fullStr Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
title_full_unstemmed Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
title_sort Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center?
author Hasslocher-Moreno, Alejandro Marcel
author_facet Hasslocher-Moreno, Alejandro Marcel
Georg, Ingebourg
Sangenis, Luiz H. C.
Mediano, Mauro F. F.
author_role author
author2 Georg, Ingebourg
Sangenis, Luiz H. C.
Mediano, Mauro F. F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Hasslocher-Moreno, Alejandro Marcel
Georg, Ingebourg
Sangenis, Luiz H. C.
Mediano, Mauro F. F.
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Rapid test
ELISA
Chemoluminescence
Sensitivity
Specificity
topic Chagas disease
Rapid test
ELISA
Chemoluminescence
Sensitivity
Specificity
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-22T00:08:56Z
dc.date.available.fl_str_mv 2021-12-22T00:08:56Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HASSLOCHER-MORENO, Alejandro M. et al. Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center? Microbes, Infection and Chemotherapy, v. 1, e1236, p. 1-3, 2021
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50516
dc.identifier.issn.pt_BR.fl_str_mv 2789-4274
dc.identifier.doi.none.fl_str_mv 10.54034/mic.e1236
identifier_str_mv HASSLOCHER-MORENO, Alejandro M. et al. Sensitivity and specificity of a rapid diagnostic test for chronic Chagas disease at a referral center in Brazil - can it be included as a standard serological diagnostic test in the clinical practice of a referral center? Microbes, Infection and Chemotherapy, v. 1, e1236, p. 1-3, 2021
2789-4274
10.54034/mic.e1236
url https://www.arca.fiocruz.br/handle/icict/50516
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50516/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50516/2/Sensitivity_Alejandro_Moreno_etal_INI_2021.pdf
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