Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28919 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil. |
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Lemos, Julia P.Smaniotto, SaleteMessias, Carolina V.Moreira, Otacilio C.Almeida, Vinicius Cotta deDardenne, MireilleSavino, WilsonCruz, Daniella A. Mendes da2018-09-20T10:51:20Z2018-09-20T10:51:20Z2018LEMOS, Julia P. et al. Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders. International Journal of Molecular Sciences, v.19, 1446, 14p, 2018.1661-6596https://www.arca.fiocruz.br/handle/icict/2891910.3390/ijms190514461422-0067engMDPITimocamundongos diabéticos não obesosmigração celularesfingosina-1-fosfatoreceptor de esfingosina-1-fosfato 1non-obese diabetic micethymussphingosine-1-phosphatesphingosine-1-phosphate receptor 1VLA-5 (very late antigen-5)cell migrationSphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disordersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil / Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Laboratório de Biologia Celular. Maceió, AL, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bilogia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil.French National Center for Scientific Research (CNRS). Mixed Research Unit (UMR) 8147. Paris Descartes University. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil.NOD (non-obese diabetic) mice spontaneously develop type 1 diabetes following T cell-dependent destruction of pancreatic β cells. Several alterations are observed in the NOD thymus, including the presence of giant perivascular spaces (PVS) filled with single-positive (SP) CD4⁺ and CD8⁺ T cells that accumulate in the organ. These cells have a decreased expression of membrane CD49e (the α5 integrin chain of the fibronectin receptor VLA-5 (very late antigen-5). Herein, we observed lower sphingosine-1-phosphate receptor 1 (S1P1) expression in NOD mouse thymocytes when compared with controls, mainly in the mature SP CD4⁺CD62Lhi and CD8⁺CD62Lhi subpopulations bearing the CD49e− phenotype. In contrast, differences in S1P1 expression were not observed in mature CD49e⁺ thymocytes. Functionally, NOD CD49e− thymocytes had reduced S1P-driven migratory response, whereas CD49e⁺ cells were more responsive to S1P. We further noticed a decreased expression of the sphingosine-1-phosphate lyase (SGPL1) in NOD SP thymocytes, which can lead to a higher sphingosine-1-phosphate (S1P) expression around PVS and S1P1 internalization. In summary, our results indicate that the modulation of S1P1 expression and S1P/S1P1 interactions in NOD mouse thymocytes are part of the T-cell migratory disorder observed during the pathogenesis of type 1 diabetes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28919/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjulia_lemos_etal_IOC_2018.pdfjulia_lemos_etal_IOC_2018.pdfapplication/pdf4459831https://www.arca.fiocruz.br/bitstream/icict/28919/2/julia_lemos_etal_IOC_2018.pdf1a614a6047f96a7e570d0ae1b5d3a9b6MD52TEXTjulia_lemos_etal_IOC_2018.pdf.txtjulia_lemos_etal_IOC_2018.pdf.txtExtracted texttext/plain67072https://www.arca.fiocruz.br/bitstream/icict/28919/3/julia_lemos_etal_IOC_2018.pdf.txt5f87be5c5a4732caeae1a9376b8f6111MD53icict/289192022-06-24 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| dc.title.pt_BR.fl_str_mv |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders |
| title |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders |
| spellingShingle |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders Lemos, Julia P. Timo camundongos diabéticos não obesos migração celular esfingosina-1-fosfato receptor de esfingosina-1-fosfato 1 non-obese diabetic mice thymus sphingosine-1-phosphate sphingosine-1-phosphate receptor 1 VLA-5 (very late antigen-5) cell migration |
| title_short |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders |
| title_full |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders |
| title_fullStr |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders |
| title_full_unstemmed |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders |
| title_sort |
Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders |
| author |
Lemos, Julia P. |
| author_facet |
Lemos, Julia P. Smaniotto, Salete Messias, Carolina V. Moreira, Otacilio C. Almeida, Vinicius Cotta de Dardenne, Mireille Savino, Wilson Cruz, Daniella A. Mendes da |
| author_role |
author |
| author2 |
Smaniotto, Salete Messias, Carolina V. Moreira, Otacilio C. Almeida, Vinicius Cotta de Dardenne, Mireille Savino, Wilson Cruz, Daniella A. Mendes da |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lemos, Julia P. Smaniotto, Salete Messias, Carolina V. Moreira, Otacilio C. Almeida, Vinicius Cotta de Dardenne, Mireille Savino, Wilson Cruz, Daniella A. Mendes da |
| dc.subject.other.pt_BR.fl_str_mv |
Timo camundongos diabéticos não obesos migração celular esfingosina-1-fosfato receptor de esfingosina-1-fosfato 1 |
| topic |
Timo camundongos diabéticos não obesos migração celular esfingosina-1-fosfato receptor de esfingosina-1-fosfato 1 non-obese diabetic mice thymus sphingosine-1-phosphate sphingosine-1-phosphate receptor 1 VLA-5 (very late antigen-5) cell migration |
| dc.subject.en.pt_BR.fl_str_mv |
non-obese diabetic mice thymus sphingosine-1-phosphate sphingosine-1-phosphate receptor 1 VLA-5 (very late antigen-5) cell migration |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em NeuroImunoModulação. Rio de Janeiro, RJ, Brasil. |
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2018 |
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2018-09-20T10:51:20Z |
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2018-09-20T10:51:20Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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LEMOS, Julia P. et al. Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders. International Journal of Molecular Sciences, v.19, 1446, 14p, 2018. |
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https://www.arca.fiocruz.br/handle/icict/28919 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1661-6596 |
| dc.identifier.eissn.none.fl_str_mv |
10.3390/ijms19051446 1422-0067 |
| identifier_str_mv |
LEMOS, Julia P. et al. Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders. International Journal of Molecular Sciences, v.19, 1446, 14p, 2018. 1661-6596 10.3390/ijms19051446 1422-0067 |
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