Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26235 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Curvo, Eduardo O. V.Ferreira, Roberto R.Madeira, Fabiana S.Alves, Gabriel F.Chambela, Mayara C.Mendes, Veronica G.Sangenis, Luiz Henrique C.Waghabi, Mariana C.Saraiva, Roberto M.2018-05-03T13:48:47Z2018-05-03T13:48:47Z2018CURVO, Eduardo O. V. et al. Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 4, p. 1-8, 2018.0074-0276https://www.arca.fiocruz.br/handle/icict/2623510.1590/0074-027601704401678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzDoença de ChagasEcocardiografiaFator de necrose tumoralFator de crescimento transformador beta 1Peptídeo natriurético cerebralChagas DiseaseTumour necrosis factorTransforming growth factor beta 1Brain natriuretic peptideEchocardiographyCorrelation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.BACKGROUND: Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function. OBJECTIVES We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease. METHODS: This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function. FINDINGS: TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction. CONCLUSIONS: TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26235/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmariana_waghabi_etal_IOC_2018.pdfmariana_waghabi_etal_IOC_2018.pdfapplication/pdf414205https://www.arca.fiocruz.br/bitstream/icict/26235/2/mariana_waghabi_etal_IOC_2018.pdf9bdd30942004a189404f74c0d3981a61MD52TEXTmariana_waghabi_etal_IOC_2018.pdf.txtmariana_waghabi_etal_IOC_2018.pdf.txtExtracted texttext/plain42483https://www.arca.fiocruz.br/bitstream/icict/26235/3/mariana_waghabi_etal_IOC_2018.pdf.txt09a8c6c8837f789e979b3125960e1e5bMD53icict/262352023-09-05 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| dc.title.pt_BR.fl_str_mv |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease |
| title |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease |
| spellingShingle |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease Curvo, Eduardo O. V. Doença de Chagas Ecocardiografia Fator de necrose tumoral Fator de crescimento transformador beta 1 Peptídeo natriurético cerebral Chagas Disease Tumour necrosis factor Transforming growth factor beta 1 Brain natriuretic peptide Echocardiography |
| title_short |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease |
| title_full |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease |
| title_fullStr |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease |
| title_full_unstemmed |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease |
| title_sort |
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease |
| author |
Curvo, Eduardo O. V. |
| author_facet |
Curvo, Eduardo O. V. Ferreira, Roberto R. Madeira, Fabiana S. Alves, Gabriel F. Chambela, Mayara C. Mendes, Veronica G. Sangenis, Luiz Henrique C. Waghabi, Mariana C. Saraiva, Roberto M. |
| author_role |
author |
| author2 |
Ferreira, Roberto R. Madeira, Fabiana S. Alves, Gabriel F. Chambela, Mayara C. Mendes, Veronica G. Sangenis, Luiz Henrique C. Waghabi, Mariana C. Saraiva, Roberto M. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Curvo, Eduardo O. V. Ferreira, Roberto R. Madeira, Fabiana S. Alves, Gabriel F. Chambela, Mayara C. Mendes, Veronica G. Sangenis, Luiz Henrique C. Waghabi, Mariana C. Saraiva, Roberto M. |
| dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Ecocardiografia Fator de necrose tumoral Fator de crescimento transformador beta 1 Peptídeo natriurético cerebral |
| topic |
Doença de Chagas Ecocardiografia Fator de necrose tumoral Fator de crescimento transformador beta 1 Peptídeo natriurético cerebral Chagas Disease Tumour necrosis factor Transforming growth factor beta 1 Brain natriuretic peptide Echocardiography |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas Disease Tumour necrosis factor Transforming growth factor beta 1 Brain natriuretic peptide Echocardiography |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2018 |
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2018-05-03T13:48:47Z |
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2018-05-03T13:48:47Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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CURVO, Eduardo O. V. et al. Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 4, p. 1-8, 2018. |
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https://www.arca.fiocruz.br/handle/icict/26235 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760170440 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
CURVO, Eduardo O. V. et al. Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 4, p. 1-8, 2018. 0074-0276 10.1590/0074-02760170440 1678-8060 |
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