Hantavirus pulmonary syndrome in a highly endemic area of Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31385 |
Resumo: | Fundação Oswaldo Cruz .Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. |
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Oliveira, R. C.Sant'ana, M. M.Guterres, A.Fernandes, J.Hillesheim, N. L. F. K.Lucini, C.Gomes, R.Lamas, C.Bochner, R.Zeccer, S.Lemos, E. R. S. de2019-02-03T02:48:12Z2019-02-03T02:48:12Z2016OLIVEIRA, R. C. et al. Hantavirus pulmonary syndrome in a highly endemic area of Brazil. Epidemiology and Infection, v. 144, p. 1096–1106, 2016.0950-2688https://www.arca.fiocruz.br/handle/icict/3138510.1017/S09502688150024601469-4409engCambridge University PressHantavirus pulmonary syndrome in a highly endemic area of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz .Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Secretaria de Saúde do Estado de Santa Catarina. Setor de Vigilância Epidemiológica. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz .Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz .Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Secretaria Municipal de Saúde. Setor de Vigilância Epidemiológica. Concórdia, SC, Brasil.Secretaria Municipal de Saúde. Setor de Vigilância Epidemiológica. Joaçaba, SC, Brasil.Fundação Oswaldo Cruz .Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Laboratório de Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil.Secretaria de Saúde do Estado de Santa Catarina. Setor de Vigilância Epidemiológica. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz .Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.Hantavirus pulmonary syndrome (HPS) is the most frequently reported fatal rodent-borne disease in Brazil, with the majority of cases occurring in Santa Catarina. We analysed the clinical, laboratory and epidemiological data of the 251 confirmed cases of HPS in Santa Catarina in 1999-2011. The number of cases ranged from 10 to 47 per year, with the highest incidences in 2004-2006. Gastrointestinal tract manifestations were found in >60% of the cases, potentially confounding diagnosis and leading to inappropriate therapy. Dyspnoea, acute respiratory failure, renal failure, increased serum creatinine and urea levels, increased haematocrits and the presence of pulmonary interstitial infiltrate were significantly more common in HPS patients who died. In addition, we demonstrated that the six cases from the midwest region of the state were associated with Juquitiba virus genotype. The case-fatality rate in this region, 19·2%, was lower than that recorded for other mesoregions. In the multivariate analysis increase of serum creatinine and urea was associated with death by HPS. Our findings help elucidate the epidemiology of HPS in Brazil, where mast seeding of bamboo can trigger rodent population eruptions and subsequent human HPS outbreaks. We also emphasize the need for molecular confirmation of the hantavirus genotype of human cases for a better understanding of the mortality-related factors associated with HPS cases in Brazil.Hantavirus pulmonary syndromeCase seriesBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31385/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Oliveira_RC_etal_INI_2016.pdfve_Oliveira_RC_etal_INI_2016.pdfapplication/pdf568803https://www.arca.fiocruz.br/bitstream/icict/31385/2/ve_Oliveira_RC_etal_INI_2016.pdf31648f25a369ac4348110585b40c389fMD52TEXTve_Oliveira_RC_etal_INI_2016.pdf.txtve_Oliveira_RC_etal_INI_2016.pdf.txtExtracted texttext/plain44947https://www.arca.fiocruz.br/bitstream/icict/31385/3/ve_Oliveira_RC_etal_INI_2016.pdf.txt3dc3fc815818fb2b038db55937f47509MD53icict/313852019-02-03 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| dc.title.pt_BR.fl_str_mv |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil |
| title |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil |
| spellingShingle |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil Oliveira, R. C. Hantavirus pulmonary syndrome Case series Brazil |
| title_short |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil |
| title_full |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil |
| title_fullStr |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil |
| title_full_unstemmed |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil |
| title_sort |
Hantavirus pulmonary syndrome in a highly endemic area of Brazil |
| author |
Oliveira, R. C. |
| author_facet |
Oliveira, R. C. Sant'ana, M. M. Guterres, A. Fernandes, J. Hillesheim, N. L. F. K. Lucini, C. Gomes, R. Lamas, C. Bochner, R. Zeccer, S. Lemos, E. R. S. de |
| author_role |
author |
| author2 |
Sant'ana, M. M. Guterres, A. Fernandes, J. Hillesheim, N. L. F. K. Lucini, C. Gomes, R. Lamas, C. Bochner, R. Zeccer, S. Lemos, E. R. S. de |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, R. C. Sant'ana, M. M. Guterres, A. Fernandes, J. Hillesheim, N. L. F. K. Lucini, C. Gomes, R. Lamas, C. Bochner, R. Zeccer, S. Lemos, E. R. S. de |
| dc.subject.en.pt_BR.fl_str_mv |
Hantavirus pulmonary syndrome Case series Brazil |
| topic |
Hantavirus pulmonary syndrome Case series Brazil |
| description |
Fundação Oswaldo Cruz .Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. |
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2016 |
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2016 |
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2019-02-03T02:48:12Z |
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2019-02-03T02:48:12Z |
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OLIVEIRA, R. C. et al. Hantavirus pulmonary syndrome in a highly endemic area of Brazil. Epidemiology and Infection, v. 144, p. 1096–1106, 2016. |
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https://www.arca.fiocruz.br/handle/icict/31385 |
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0950-2688 |
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10.1017/S0950268815002460 |
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1469-4409 |
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OLIVEIRA, R. C. et al. Hantavirus pulmonary syndrome in a highly endemic area of Brazil. Epidemiology and Infection, v. 144, p. 1096–1106, 2016. 0950-2688 10.1017/S0950268815002460 1469-4409 |
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Cambridge University Press |
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Cambridge University Press |
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