The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Jessica E.S.
Data de Publicação: 2017
Outros Autores: Andrade, Cecilia Vianna de, Rossomano, Fabio B., Nuovo, Gerard J., Amaro Filho, Sergio M., Carvalho, Maria O. O., Nicol, Alcina Frederica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25020
Resumo: Instituto Brasileiro de Medicina e Reabilitação. Rio de Janeiro, RJ, Brasil
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spelling Gonçalves, Jessica E.S.Andrade, Cecilia Vianna deRossomano, Fabio B.Nuovo, Gerard J.Amaro Filho, Sergio M.Carvalho, Maria O. O.Nicol, Alcina Frederica2018-03-01T16:30:15Z2018-03-01T16:30:15Z2017GONÇALVES, Jessica E. S. et al. The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?. MedicalExpress, v.4, n.6, M170601, 5p, Dec. 2017.2318-8111https://www.arca.fiocruz.br/handle/icict/2502010.5935/MedicalExpress.2017.06.012358-0429engMavera, Edições Científicas e Técnicas LtdaInfecção por HPVPapillomaviridaeBiomarcadoresNeoplasias do Colo do Úterolesão intra-epitelial cervicalp16 proteinHPV infectioncervical cancerbiomarkercervical intraepithelial lesionThe role of p16 as putative biomarker for cervical neoplasia: A controversial issue?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Brasileiro de Medicina e Reabilitação. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.State University Comprehensive Cancer Center. Columbus, OH, USA.Instituto Nacional de Câncer. Divisão de Genética. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.INTRODUCTION: Protein p16 has been extensively studied as a potential biomarker for precursor lesions to distinguish cervical Intraepithelial neoplasia (CIN) from their mimics. However, the use of p16 as prognostic biomarker for diagnosis of cervical cancer and precancer is controversial. This study focuses on the assessment of peer-reviewed scientific data related to the use of p16 to predict disease severity and its controversies. METHODS: We reviewed publications in MEDLINE/PubMed assessing the clinical, diagnostic and prognostic significance of p16 in CIN and cervical cancer; we included publications from 2009 to June 2017. RESULTS: The use of p16 as a prognostic marker is still unreliable, although it could be a useful tool for diagnosis of Cervical Intraepithelial Neoplasia lesions with undetermined morphology. Moreover, p16 appears to be a specific marker of high-risk oncogenic HPV infection. CONCLUSION: This review shows the potential utility and drawbacks of p16 for clinical practice and the diagnosis of cervical cancer. Further studies are required to substantiate the role of p16 in conjunction with other more sensitive and specific biomarkers for diagnosing CIN and predicting its progression.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25020/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalcinaf_nicol_etal_IOC_2017.pdfalcinaf_nicol_etal_IOC_2017.pdfapplication/pdf282043https://www.arca.fiocruz.br/bitstream/icict/25020/2/alcinaf_nicol_etal_IOC_2017.pdfa766894a85bdf3650c4e0d6878e5ecffMD52TEXTalcinaf_nicol_etal_IOC_2017.pdf.txtalcinaf_nicol_etal_IOC_2017.pdf.txtExtracted texttext/plain24149https://www.arca.fiocruz.br/bitstream/icict/25020/3/alcinaf_nicol_etal_IOC_2017.pdf.txtadd38e1df2001670bc5320d02f797d6dMD53icict/250202018-08-15 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dc.title.pt_BR.fl_str_mv The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
title The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
spellingShingle The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
Gonçalves, Jessica E.S.
Infecção por HPV
Papillomaviridae
Biomarcadores
Neoplasias do Colo do Útero
lesão intra-epitelial cervical
p16 protein
HPV infection
cervical cancer
biomarker
cervical intraepithelial lesion
title_short The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
title_full The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
title_fullStr The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
title_full_unstemmed The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
title_sort The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?
author Gonçalves, Jessica E.S.
author_facet Gonçalves, Jessica E.S.
Andrade, Cecilia Vianna de
Rossomano, Fabio B.
Nuovo, Gerard J.
Amaro Filho, Sergio M.
Carvalho, Maria O. O.
Nicol, Alcina Frederica
author_role author
author2 Andrade, Cecilia Vianna de
Rossomano, Fabio B.
Nuovo, Gerard J.
Amaro Filho, Sergio M.
Carvalho, Maria O. O.
Nicol, Alcina Frederica
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Jessica E.S.
Andrade, Cecilia Vianna de
Rossomano, Fabio B.
Nuovo, Gerard J.
Amaro Filho, Sergio M.
Carvalho, Maria O. O.
Nicol, Alcina Frederica
dc.subject.other.pt_BR.fl_str_mv Infecção por HPV
Papillomaviridae
Biomarcadores
Neoplasias do Colo do Útero
lesão intra-epitelial cervical
topic Infecção por HPV
Papillomaviridae
Biomarcadores
Neoplasias do Colo do Útero
lesão intra-epitelial cervical
p16 protein
HPV infection
cervical cancer
biomarker
cervical intraepithelial lesion
dc.subject.en.pt_BR.fl_str_mv p16 protein
HPV infection
cervical cancer
biomarker
cervical intraepithelial lesion
description Instituto Brasileiro de Medicina e Reabilitação. Rio de Janeiro, RJ, Brasil
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-01T16:30:15Z
dc.date.available.fl_str_mv 2018-03-01T16:30:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, Jessica E. S. et al. The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?. MedicalExpress, v.4, n.6, M170601, 5p, Dec. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25020
dc.identifier.issn.pt_BR.fl_str_mv 2318-8111
dc.identifier.doi.none.fl_str_mv 10.5935/MedicalExpress.2017.06.01
dc.identifier.eissn.none.fl_str_mv 2358-0429
identifier_str_mv GONÇALVES, Jessica E. S. et al. The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?. MedicalExpress, v.4, n.6, M170601, 5p, Dec. 2017.
2318-8111
10.5935/MedicalExpress.2017.06.01
2358-0429
url https://www.arca.fiocruz.br/handle/icict/25020
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mavera, Edições Científicas e Técnicas Ltda
publisher.none.fl_str_mv Mavera, Edições Científicas e Técnicas Ltda
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/25020/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/25020/2/alcinaf_nicol_etal_IOC_2017.pdf
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