HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32231 |
Resumo: | Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA. |
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Castilho, Jessica L.Luz, Paula M.Shepherd, Bryan E.Turner, MeganRibeiro, Sayonara R.Bebawy, Sally S.Netto, Juliana S.McGowan, Catherine C.Veloso, Valdiléa G.Engels, Eric A.Sterling, Timothy R.Grinsztejn, Beatriz2019-03-26T12:10:37Z2019-03-26T12:10:37Z2015CASTILHO, Jessica L. et al. HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts. Infectious Agents and Cancer, v. 10, n. 4, p. 1-10, 2015.1750-9378https://www.arca.fiocruz.br/handle/icict/322311750-9378engBMCHIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohortsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Vanderbilt University School of Medicine. Department of Biostatistics. Nashville, TN, USA.Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.National Cancer Institute. Division of Cancer Epidemiology and Genetics. Bethesda, MD, USA.Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Background: With successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not been well described. It is not known if cancer trends in HIV-infected populations in Brazil are similar to those of other countries where antiretroviral therapy is also widely available. Methods: We performed a retrospective analysis of clinical cohorts at Instituto Nacional de Infectologia Evandro Chagas (INI) in Rio de Janeiro and Vanderbilt Comprehensive Care Clinic (VCCC) in Nashville from 1998 to 2010. We used Poisson regression and standardized incidence ratios (SIRs) to examine incidence trends. Clinical and demographic predictors of ADCs and NADCs were examined using Cox proportional hazards models. Results: This study included 2,925 patients at INI and 3,927 patients at VCCC. There were 57 ADCs at INI (65% Kaposi sarcoma), 47 at VCCC (40% Kaposi sarcoma), 45 NADCs at INI, and 82 at VCCC. From 1998 to 2004, incidence of ADCs remained statistically unchanged at both sites. From 2005 to 2010, ADC incidence decreased in both cohorts (INI incidence rate ratio per year = 0.74, p < 0.01; VCCC = 0.75, p < 0.01). Overall Kaposi sarcoma incidence was greater at INI than VCCC (3.0 vs. 1.2 cases per 1,000 person-years, p < 0.01). Incidence of NADCs remained constant throughout the study period (overall INI incidence 3.6 per 1,000 person-years and VCCC incidence 5.3 per 1,000 person-years). Compared to general populations, overall risk of NADCs was increased at both sites (INI SIR = 1.4 [95% CI 1.1-1.9] and VCCC SIR = 1.3 [1.0-1.7]). After non-melanoma skin cancers, the most frequent NADCs were anal cancer at INI (n = 7) and lung cancer at VCCC (n = 11). In multivariate models, risk of ADC was associated with male sex and immunosuppression. Risk of NADC was associated with increased age. Conclusions: In both cohorts, ADCs have decreased over time, though incidence of KS was higher at INI than VCCC. Rates of NADCs remained constant over time at both sites.HIVMalignancyCancerBrazilAnal cancerKaposi sarcomaNon-Hodgkin lymphomaLung cancerinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32231/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Castilho_Jessica_etal_INI_2015.pdfve_Castilho_Jessica_etal_INI_2015.pdfapplication/pdf311811https://www.arca.fiocruz.br/bitstream/icict/32231/2/ve_Castilho_Jessica_etal_INI_2015.pdf54800a9f546a95037ba881b7f282e00eMD52TEXTve_Castilho_Jessica_etal_INI_2015.pdf.txtve_Castilho_Jessica_etal_INI_2015.pdf.txtExtracted texttext/plain48255https://www.arca.fiocruz.br/bitstream/icict/32231/3/ve_Castilho_Jessica_etal_INI_2015.pdf.txt1a1d8f00dcff39089f004781d675d810MD53icict/322312019-04-04 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| dc.title.pt_BR.fl_str_mv |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts |
| title |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts |
| spellingShingle |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts Castilho, Jessica L. HIV Malignancy Cancer Brazil Anal cancer Kaposi sarcoma Non-Hodgkin lymphoma Lung cancer |
| title_short |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts |
| title_full |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts |
| title_fullStr |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts |
| title_full_unstemmed |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts |
| title_sort |
HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts |
| author |
Castilho, Jessica L. |
| author_facet |
Castilho, Jessica L. Luz, Paula M. Shepherd, Bryan E. Turner, Megan Ribeiro, Sayonara R. Bebawy, Sally S. Netto, Juliana S. McGowan, Catherine C. Veloso, Valdiléa G. Engels, Eric A. Sterling, Timothy R. Grinsztejn, Beatriz |
| author_role |
author |
| author2 |
Luz, Paula M. Shepherd, Bryan E. Turner, Megan Ribeiro, Sayonara R. Bebawy, Sally S. Netto, Juliana S. McGowan, Catherine C. Veloso, Valdiléa G. Engels, Eric A. Sterling, Timothy R. Grinsztejn, Beatriz |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castilho, Jessica L. Luz, Paula M. Shepherd, Bryan E. Turner, Megan Ribeiro, Sayonara R. Bebawy, Sally S. Netto, Juliana S. McGowan, Catherine C. Veloso, Valdiléa G. Engels, Eric A. Sterling, Timothy R. Grinsztejn, Beatriz |
| dc.subject.en.pt_BR.fl_str_mv |
HIV Malignancy Cancer Brazil Anal cancer Kaposi sarcoma Non-Hodgkin lymphoma Lung cancer |
| topic |
HIV Malignancy Cancer Brazil Anal cancer Kaposi sarcoma Non-Hodgkin lymphoma Lung cancer |
| description |
Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA. |
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2015 |
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2015 |
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2019-03-26T12:10:37Z |
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2019-03-26T12:10:37Z |
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CASTILHO, Jessica L. et al. HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts. Infectious Agents and Cancer, v. 10, n. 4, p. 1-10, 2015. |
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https://www.arca.fiocruz.br/handle/icict/32231 |
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1750-9378 |
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1750-9378 |
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CASTILHO, Jessica L. et al. HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts. Infectious Agents and Cancer, v. 10, n. 4, p. 1-10, 2015. 1750-9378 |
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