Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis

Detalhes bibliográficos
Autor(a) principal: Saichua, Prasert
Data de Publicação: 2013
Outros Autores: Sithithaworn, Paiboon, Jariwala, Amar R., Deimert, David J., Sithithaworn, Jiraporn, Sripa, Banchob, Laha, Thewarach, Mairiang, Eimorn, Pairojkul, Chawalit, Periago, Maria Victoria, Khuntikeo, Narong, Mulvenna, Jason, Bethony, Jeffrey Michael
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33567
Resumo: Biomedical Sciences Program. Graduate School. Khon Kaen University. Khon Kaen, Thailand.
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spelling Saichua, PrasertSithithaworn, PaiboonJariwala, Amar R.Deimert, David J.Sithithaworn, JirapornSripa, BanchobLaha, ThewarachMairiang, EimornPairojkul, ChawalitPeriago, Maria VictoriaKhuntikeo, NarongMulvenna, JasonBethony, Jeffrey Michael2019-06-18T18:22:49Z2019-06-18T18:22:49Z2013SAICHUA, Prasert et al. Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. PLoS Negl Trop Dis.,v. 7, n. 5, e2228, 20131935-2735https://www.arca.fiocruz.br/handle/icict/3356710.1371/journal.pntd.0002228engPublic Library of ScienceMicroproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBiomedical Sciences Program. Graduate School. Khon Kaen University. Khon Kaen, Thailand.Department of Parasitology. Faculty of Medicine. Khon Kaen University. Khon Kaen, Thailand./Liver Fluke and Cholangiocarcinoma Research Center. Faculty of Medicine. Khon Kaen University. Khon Kaen, Thailand.Department of Microbiology. Immunology and Tropical Medicine and Center for the Neglected Diseases of Poverty. George Washington University. Washington, D.C., United States of AmericaDepartment of Microbiology. Immunology and Tropical Medicine and Center for the Neglected Diseases of Poverty. George Washington University. Washington, D.C., United States of AmericaDepartment of Clinical Microscopy. Faculty of Associated Medical Sciences. Khon Kaen University. Khon Kaen, ThailandDepartment of Pathology. Faculty of Medicine. Khon Kaen University. Khon Kaen, ThailandDepartment of Parasitology. Faculty of Medicine. Khon Kaen University. Khon Kaen, Thailand.Department of Clinical Microscopy. Faculty of Associated Medical Sciences. Khon Kaen University. Khon Kaen, ThailandDepartment of Radiology. Faculty of Medicine. Khon Kaen University. Khon Kaen, ThailandFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, BrazilDepartment of Surgery. Faculty of Medicine. Khon Kaen University. Khon Kaen, ThailandInfections and Cancer. Queensland Institute of Medical Research.b Queensland, AustraliaDepartment of Microbiology. Immunology and Tropical Medicine and Center for the Neglected Diseases of Poverty. George Washington University. Washington, D.C., United States of AmericaApproximately 680 million people are at risk of infection with Opisthorchis viverrini (OV) and Clonorchis sinensis, with an estimated 10 million infected with OV in Southeast Asia alone. While opisthorchiasis is associated with hepatobiliary pathologies, such as advanced periductal fibrosis (APF) and cholangiocarcinoma (CCA), animal models of OV infection show that immune-complex glomerulonephritis is an important renal pathology that develops simultaneously with hepatobiliary pathologies. A cardinal sign of immune-complex glomerulonephritis is the urinary excretion of immunoglobulin G (IgG) (microproteinuria). In community-based studies in OV endemic areas along the Chi River in northeastern Thailand, we observed that over half of the participants had urine IgG against a crude OV antigen extract (OV antigen). We also observed that elevated levels of urine IgG to OV antigen were not associated with the intensity of OV infection, but were likely the result of immune-complex glomerulonephritis as seen in animal models of OV infection. Moreover, we observed that urine IgG to OV antigen was excreted at concentrations 21 times higher in individuals with APF and 158 times higher in individuals with CCA than controls. We also observed that elevated urine IgG to OV antigen could identify APF+ and CCA+ individuals from non-cases. Finally, individuals with urine IgG to OV antigen had a greater risk of APF as determined by Odds Ratios (OR = 6.69; 95%CI: 2.87, 15.58) and a greater risk of CCA (OR = 71.13; 95%CI: 15.13, 334.0) than individuals with no detectable level of urine IgG to OV antigen. Herein, we show for the first time the extensive burden of renal pathology in OV endemic areas and that a urine biomarker could serve to estimate risk for both renal and hepatobiliary pathologies during OV infection, i.e., serve as a "syndromic biomarker" of the advanced pathologies from opisthorchiasis.opisthorchiasishepatobiliary pathologiesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/33567/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALMicroproteinuria during Opisthorchis viverrini Infection.pdfMicroproteinuria during Opisthorchis viverrini Infection.pdfapplication/pdf7552568https://www.arca.fiocruz.br/bitstream/icict/33567/2/Microproteinuria%20during%20Opisthorchis%20viverrini%20Infection.pdfc4e2b545ca8e883d58964cf0e4279ed2MD52TEXTMicroproteinuria during Opisthorchis viverrini Infection.pdf.txtMicroproteinuria during Opisthorchis viverrini Infection.pdf.txtExtracted texttext/plain876https://www.arca.fiocruz.br/bitstream/icict/33567/3/Microproteinuria%20during%20Opisthorchis%20viverrini%20Infection.pdf.txtde4ea8a9774b59c0d78a9cd4df5171c2MD53icict/335672019-06-19 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dc.title.pt_BR.fl_str_mv Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
title Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
spellingShingle Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
Saichua, Prasert
opisthorchiasis
hepatobiliary pathologies
title_short Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
title_full Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
title_fullStr Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
title_full_unstemmed Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
title_sort Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
author Saichua, Prasert
author_facet Saichua, Prasert
Sithithaworn, Paiboon
Jariwala, Amar R.
Deimert, David J.
Sithithaworn, Jiraporn
Sripa, Banchob
Laha, Thewarach
Mairiang, Eimorn
Pairojkul, Chawalit
Periago, Maria Victoria
Khuntikeo, Narong
Mulvenna, Jason
Bethony, Jeffrey Michael
author_role author
author2 Sithithaworn, Paiboon
Jariwala, Amar R.
Deimert, David J.
Sithithaworn, Jiraporn
Sripa, Banchob
Laha, Thewarach
Mairiang, Eimorn
Pairojkul, Chawalit
Periago, Maria Victoria
Khuntikeo, Narong
Mulvenna, Jason
Bethony, Jeffrey Michael
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Saichua, Prasert
Sithithaworn, Paiboon
Jariwala, Amar R.
Deimert, David J.
Sithithaworn, Jiraporn
Sripa, Banchob
Laha, Thewarach
Mairiang, Eimorn
Pairojkul, Chawalit
Periago, Maria Victoria
Khuntikeo, Narong
Mulvenna, Jason
Bethony, Jeffrey Michael
dc.subject.en.pt_BR.fl_str_mv opisthorchiasis
hepatobiliary pathologies
topic opisthorchiasis
hepatobiliary pathologies
description Biomedical Sciences Program. Graduate School. Khon Kaen University. Khon Kaen, Thailand.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2019-06-18T18:22:49Z
dc.date.available.fl_str_mv 2019-06-18T18:22:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SAICHUA, Prasert et al. Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. PLoS Negl Trop Dis.,v. 7, n. 5, e2228, 2013
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33567
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0002228
identifier_str_mv SAICHUA, Prasert et al. Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. PLoS Negl Trop Dis.,v. 7, n. 5, e2228, 2013
1935-2735
10.1371/journal.pntd.0002228
url https://www.arca.fiocruz.br/handle/icict/33567
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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