Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31307 |
Resumo: | Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM), and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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Lima, Emilly Juliana Sales Pereira deAlves, Rafaela GD'Elia, Gigliola Mayara AyresAnunciação, Talita Andrade daSilva, Valdenizia RodriguesSantos, Luciano de SSoares, Milena Botelho PereiraCardozo, Nállarett Marina DávilaCosta, Emmanoel VilaçaSilva, Felipe M A daKoolen, Hector Henrique FerreiraBezerra, Daniel Pereira2019-01-24T17:56:37Z2019-01-24T17:56:37Z2018LIMA, E. J. S. P. et al. Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae). Molecules, v. 23, p. 2974, 2018.1420-3049https://www.arca.fiocruz.br/handle/icict/3130710.3390/molecules23112974Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM), and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brazil.Amazonia Museum. Manaus, AM, Brazil.Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Croton matourensis Aubl. (synonym Croton lanjouwensis Jabl.), popularly known as "orelha de burro", "maravuvuia", and/or "sangrad'água", is a medicinal plant used in Brazilian folk medicine as a depurative and in the treatment of infections, fractures, and colds. In this work, we investigated the chemical composition and in vitro cytotoxic and in vivo antitumor effects of the essential oil (EO) from the leaves of C. matourensis collected from the Amazon rainforest. The EO was obtained by hydrodistillation using a Clevenger-type apparatus and characterized qualitatively and quantitatively by gas chromatography coupled to mass spectrometry (GC⁻MS) and gas chromatography with flame ionization detection (GC⁻FID), respectively. In vitro cytotoxicity of the EO was assessed in cancer cell lines (MCF-7, HCT116, HepG2, and HL-60) and the non-cancer cell line (MRC-5) using the Alamar blue assay. Furthermore, annexin V-FITC/PI staining and the cell cycle distribution were evaluated with EO-treated HepG2 cells by flow cytometry. In vivo efficacy of the EO (40 and 80 mg/kg/day) was demonstrated in C.B-17 severe combined immunodeficient (SCID) mice with HepG2 cell xenografts. The EO included β-caryophyllene, thunbergol, cembrene, p-cymene, and β-elemene as major constituents. The EO exhibited promising cytotoxicity and was able to cause phosphatidylserine externalization and DNA fragmentation without loss of the cell membrane integrity in HepG2 cells. In vivo tumor mass inhibition rates of the EO were 34.6% to 55.9%. Altogether, these data indicate the anticancer potential effect of C. matourensis.engMDPICroton matourensisCroton lanjouwensisAntitumoralApoptoseHepG2Croton matourensisCroton lanjouwensisAntitumorApoptosisHepG2Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. 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| dc.title.pt_BR.fl_str_mv |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) |
| title |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) |
| spellingShingle |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) Lima, Emilly Juliana Sales Pereira de Croton matourensis Croton lanjouwensis Antitumoral Apoptose HepG2 Croton matourensis Croton lanjouwensis Antitumor Apoptosis HepG2 |
| title_short |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) |
| title_full |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) |
| title_fullStr |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) |
| title_full_unstemmed |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) |
| title_sort |
Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae) |
| author |
Lima, Emilly Juliana Sales Pereira de |
| author_facet |
Lima, Emilly Juliana Sales Pereira de Alves, Rafaela G D'Elia, Gigliola Mayara Ayres Anunciação, Talita Andrade da Silva, Valdenizia Rodrigues Santos, Luciano de S Soares, Milena Botelho Pereira Cardozo, Nállarett Marina Dávila Costa, Emmanoel Vilaça Silva, Felipe M A da Koolen, Hector Henrique Ferreira Bezerra, Daniel Pereira |
| author_role |
author |
| author2 |
Alves, Rafaela G D'Elia, Gigliola Mayara Ayres Anunciação, Talita Andrade da Silva, Valdenizia Rodrigues Santos, Luciano de S Soares, Milena Botelho Pereira Cardozo, Nállarett Marina Dávila Costa, Emmanoel Vilaça Silva, Felipe M A da Koolen, Hector Henrique Ferreira Bezerra, Daniel Pereira |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Emilly Juliana Sales Pereira de Alves, Rafaela G D'Elia, Gigliola Mayara Ayres Anunciação, Talita Andrade da Silva, Valdenizia Rodrigues Santos, Luciano de S Soares, Milena Botelho Pereira Cardozo, Nállarett Marina Dávila Costa, Emmanoel Vilaça Silva, Felipe M A da Koolen, Hector Henrique Ferreira Bezerra, Daniel Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Croton matourensis Croton lanjouwensis Antitumoral Apoptose HepG2 |
| topic |
Croton matourensis Croton lanjouwensis Antitumoral Apoptose HepG2 Croton matourensis Croton lanjouwensis Antitumor Apoptosis HepG2 |
| dc.subject.en.pt_BR.fl_str_mv |
Croton matourensis Croton lanjouwensis Antitumor Apoptosis HepG2 |
| description |
Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM), and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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2018 |
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2018 |
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2019-01-24T17:56:37Z |
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2019-01-24T17:56:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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LIMA, E. J. S. P. et al. Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae). Molecules, v. 23, p. 2974, 2018. |
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https://www.arca.fiocruz.br/handle/icict/31307 |
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1420-3049 |
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10.3390/molecules23112974 |
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LIMA, E. J. S. P. et al. Antitumor Effect of the Essential Oil from the Leaves of Crotonmatourensis Aubl. (Euphorbiaceae). Molecules, v. 23, p. 2974, 2018. 1420-3049 10.3390/molecules23112974 |
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