Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives

Detalhes bibliográficos
Autor(a) principal: Bispo, Marcelle de Lima Ferreira
Data de Publicação: 2012
Outros Autores: Gonçalves, Raoni Schroeder Borges, Lima, Camilo Henrique da Silva, Cardoso, Laura Nogueira de Faria, Lourenço, Maria Cristina Silva, Souza, Marcus Vinícius Nora de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57243
Resumo: Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil.
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spelling Bispo, Marcelle de Lima FerreiraGonçalves, Raoni Schroeder BorgesLima, Camilo Henrique da SilvaCardoso, Laura Nogueira de FariaLourenço, Maria Cristina SilvaSouza, Marcus Vinícius Nora de2023-03-03T18:50:42Z2023-03-03T18:50:42Z2012BISPO, Marcelle de Lima Ferreira et al. Synthesis and antitubercular evaluation of N‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide derivatives. Journal of Heterocyclic Chemistry, v. 49, n. 6, p. 1317-1322, Nov. 2012.0022-152Xhttps://www.arca.fiocruz.br/handle/icict/5724310.1002/jhet.921engHetero CorporationSynthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil.Two series of pyrazinamide (PZA) derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Some compounds exhibited minimum inhibitory concentration activity of 50–100 μg/mL, greater than the first line antituberculosis drug PZA in Alamar Blue assay (>100 μg/mL). The obtained activities can be considered promising results, which characterizes these compounds as good start points to development of new antitubercular agents.Pyrazinamide (PZA)Mycobacterium tuberculosis H37RvAntituberculosis drug PZAinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Bispo_Marcelle_etal_FAR_INI_2012.pdfve_Bispo_Marcelle_etal_FAR_INI_2012.pdfapplication/pdf213661https://www.arca.fiocruz.br/bitstream/icict/57243/2/ve_Bispo_Marcelle_etal_FAR_INI_2012.pdf70b779370f3abdf7f8eebe379d0dc1c3MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57243/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/572432023-03-03 15:54:12.635oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-03T18:54:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
title Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
spellingShingle Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
Bispo, Marcelle de Lima Ferreira
Pyrazinamide (PZA)
Mycobacterium tuberculosis H37Rv
Antituberculosis drug PZA
title_short Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
title_full Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
title_fullStr Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
title_full_unstemmed Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
title_sort Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives
author Bispo, Marcelle de Lima Ferreira
author_facet Bispo, Marcelle de Lima Ferreira
Gonçalves, Raoni Schroeder Borges
Lima, Camilo Henrique da Silva
Cardoso, Laura Nogueira de Faria
Lourenço, Maria Cristina Silva
Souza, Marcus Vinícius Nora de
author_role author
author2 Gonçalves, Raoni Schroeder Borges
Lima, Camilo Henrique da Silva
Cardoso, Laura Nogueira de Faria
Lourenço, Maria Cristina Silva
Souza, Marcus Vinícius Nora de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bispo, Marcelle de Lima Ferreira
Gonçalves, Raoni Schroeder Borges
Lima, Camilo Henrique da Silva
Cardoso, Laura Nogueira de Faria
Lourenço, Maria Cristina Silva
Souza, Marcus Vinícius Nora de
dc.subject.en.en_US.fl_str_mv Pyrazinamide (PZA)
Mycobacterium tuberculosis H37Rv
Antituberculosis drug PZA
topic Pyrazinamide (PZA)
Mycobacterium tuberculosis H37Rv
Antituberculosis drug PZA
description Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2023-03-03T18:50:42Z
dc.date.available.fl_str_mv 2023-03-03T18:50:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BISPO, Marcelle de Lima Ferreira et al. Synthesis and antitubercular evaluation of N‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide derivatives. Journal of Heterocyclic Chemistry, v. 49, n. 6, p. 1317-1322, Nov. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57243
dc.identifier.issn.en_US.fl_str_mv 0022-152X
dc.identifier.doi.none.fl_str_mv 10.1002/jhet.921
identifier_str_mv BISPO, Marcelle de Lima Ferreira et al. Synthesis and antitubercular evaluation of N‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide derivatives. Journal of Heterocyclic Chemistry, v. 49, n. 6, p. 1317-1322, Nov. 2012.
0022-152X
10.1002/jhet.921
url https://www.arca.fiocruz.br/handle/icict/57243
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hetero Corporation
publisher.none.fl_str_mv Hetero Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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