Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets

Detalhes bibliográficos
Autor(a) principal: Cordeiro, Ana Paula
Data de Publicação: 2015
Outros Autores: Pereira, Rosiane Aparecida Silva, Chapeaurouge, Alex, Coimbra, Clarice Semião, Perales, Jonas, Oliveira, Guilherme, Candiani, Talitah Michel Sanchez, Coimbra, Roney Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13107
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou (CPqRR). Grupo de Pesquisa em Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil.
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spelling Cordeiro, Ana PaulaPereira, Rosiane Aparecida SilvaChapeaurouge, AlexCoimbra, Clarice SemiãoPerales, JonasOliveira, GuilhermeCandiani, Talitah Michel SanchezCoimbra, Roney Santos2016-03-10T15:07:20Z2016-03-10T15:07:20Z2015CORDEIRO, Ana Paula; et al. Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets. BMC Genomics, v.16, Suppl 5, S11, 2015.1471-2164https://www.arca.fiocruz.br/handle/icict/1310710.1186/1471-2164-16-S5-S11engBioMed CentralComparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa René Rachou (CPqRR). Grupo de Pesquisa em Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou (CPqRR). Grupo de Pesquisa em Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou (CPqRR). Grupo de Pesquisa em Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou (CPqRR). Grupo de Pesquisa em Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil.FHEMIG. Hospital de Crianças João Paulo II. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou (CPqRR). Grupo de Pesquisa Informática de Biosistemas. Belo Horizonte, MG, Brasil.Background: Meningitis is the inflammation of the meninges in response to infection or chemical agents. While aseptic meningitis, most frequently caused by enteroviruses, is usually benign with a self-limiting course, bacterial meningitis remains associated with high morbidity and mortality rates, despite advances in antimicrobial therapy and intensive care. Fast and accurate differential diagnosis is crucial for assertive choice of the appropriate therapeutic approach for each form of meningitis. Methods: We used 2D-PAGE and mass spectrometry to identify the cerebrospinal fluid proteome specifically related to the host response to pneumococcal, meningococcal, and enteroviral meningitis. The disease-specific proteome signatures were inspected by pathway analysis. Results: Unique cerebrospinal fluid proteome signatures were found to the three aetiological forms of meningitis investigated, and a qualitative predictive model with four protein markers was developed for the differential diagnosis of these diseases. Nevertheless, pathway analysis of the disease-specific proteomes unveiled that Kallikrein-kinin system may play a crucial role in the pathophysiological mechanisms leading to brain damage in bacterial meningitis. Proteins taking part in this cellular process are proposed as putative targets to novel adjunctive therapies. Conclusions: Comparative proteomics of cerebrospinal fluid disclosed candidate biomarkers, which were combined in a qualitative and sequential predictive model with potential to improve the differential diagnosis of pneumococcal, meningococcal and enteroviral meningitis. Moreover, we present the first evidence of the possible implication of Kallikrein-kinin system in the pathophysiology of bacterial meningitis.Comparative proteomicsCerebrospinal fluidPneumococcal meningitisMeningococcal meningitisEnteroviral meningitisProteômicaLíquido CefalorraquidianoMeningite PneumocócicaMeningite MeningocócicaMeningite viralinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13107/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalex_chapeaurouge_etal_IOC_2015.pdfalex_chapeaurouge_etal_IOC_2015.pdfapplication/pdf343462https://www.arca.fiocruz.br/bitstream/icict/13107/2/alex_chapeaurouge_etal_IOC_2015.pdfdeaf5a5bf883dc052b8cdda7882ad5b1MD52TEXTalex_chapeaurouge_etal_IOC_2015.pdf.txtalex_chapeaurouge_etal_IOC_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
title Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
spellingShingle Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
Cordeiro, Ana Paula
Comparative proteomics
Cerebrospinal fluid
Pneumococcal meningitis
Meningococcal meningitis
Enteroviral meningitis
Proteômica
Líquido Cefalorraquidiano
Meningite Pneumocócica
Meningite Meningocócica
Meningite viral
title_short Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
title_full Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
title_fullStr Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
title_full_unstemmed Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
title_sort Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets
author Cordeiro, Ana Paula
author_facet Cordeiro, Ana Paula
Pereira, Rosiane Aparecida Silva
Chapeaurouge, Alex
Coimbra, Clarice Semião
Perales, Jonas
Oliveira, Guilherme
Candiani, Talitah Michel Sanchez
Coimbra, Roney Santos
author_role author
author2 Pereira, Rosiane Aparecida Silva
Chapeaurouge, Alex
Coimbra, Clarice Semião
Perales, Jonas
Oliveira, Guilherme
Candiani, Talitah Michel Sanchez
Coimbra, Roney Santos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cordeiro, Ana Paula
Pereira, Rosiane Aparecida Silva
Chapeaurouge, Alex
Coimbra, Clarice Semião
Perales, Jonas
Oliveira, Guilherme
Candiani, Talitah Michel Sanchez
Coimbra, Roney Santos
dc.subject.en.pt_BR.fl_str_mv Comparative proteomics
Cerebrospinal fluid
Pneumococcal meningitis
Meningococcal meningitis
Enteroviral meningitis
topic Comparative proteomics
Cerebrospinal fluid
Pneumococcal meningitis
Meningococcal meningitis
Enteroviral meningitis
Proteômica
Líquido Cefalorraquidiano
Meningite Pneumocócica
Meningite Meningocócica
Meningite viral
dc.subject.decs.pt_BR.fl_str_mv Proteômica
Líquido Cefalorraquidiano
Meningite Pneumocócica
Meningite Meningocócica
Meningite viral
description Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou (CPqRR). Grupo de Pesquisa em Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-10T15:07:20Z
dc.date.available.fl_str_mv 2016-03-10T15:07:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CORDEIRO, Ana Paula; et al. Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets. BMC Genomics, v.16, Suppl 5, S11, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13107
dc.identifier.issn.none.fl_str_mv 1471-2164
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2164-16-S5-S11
identifier_str_mv CORDEIRO, Ana Paula; et al. Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets. BMC Genomics, v.16, Suppl 5, S11, 2015.
1471-2164
10.1186/1471-2164-16-S5-S11
url https://www.arca.fiocruz.br/handle/icict/13107
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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