Eosinophil recruitment and activation: the role of lipid mediators

Detalhes bibliográficos
Autor(a) principal: Gomes, Tatiana Luna
Data de Publicação: 2013
Outros Autores: Bozza, Patrícia T., Melo, Christiane Bandeira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11758
Resumo: Universidade Federal do Rio deJaneiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
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spelling Gomes, Tatiana LunaBozza, Patrícia T.Melo, Christiane Bandeira2015-09-21T17:25:40Z2015-09-21T17:25:40Z2013GOMES, Tatiana Luna; BOZZA, Patrícia T.; MELO, Christiane Bandeira. Eosinophil recruitment and activation: the role of lipid mediators. Front. Pharmacol., v.4, n.27, Mar. 2013.1663-4365https://www.arca.fiocruz.br/handle/icict/1175810.3389/fphar.2013.00027engFrontiers Media S.A.Eosinophil recruitment and activation: the role of lipid mediatorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio deJaneiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio deJaneiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Eosinophils are effector cells that migrate toward several mediators released at inflammatory sites to perform their multiple functions. The mechanisms driving eosinophil selective accumulation in sites of allergic inflammation are well-established and involve several steps controlled by adhesion molecules, priming agents, chemotactic, and surviving factors. Even though the majority of studies focused on role of protein mediators like IL-5 and eotaxins, lipid mediators also participate in eosinophil recruitment and activation. Among the lipid mediators with distinguish eosinophil recruitment and activation capabilities are platelet activating factor and the eicosanoids, including leukotriene B4, cysteinyl leukotrienes, and prostaglandin D2. In this review, we focused on the role of these four lipid mediators in eosinophil recruitment and activation, since they are recognized as key mediators of eosinophilic inflammatory responses.EosinophilChemotaxisLipid mediatorsProstaglandinsProstaglandinasEosinófiloProstaglandinasLeukotrienesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11758/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALpatricia_bozza_etal_IOC_2013.pdfapplication/pdf951959https://www.arca.fiocruz.br/bitstream/icict/11758/2/patricia_bozza_etal_IOC_2013.pdfb16383f01276823a94cbe263a771d3beMD52TEXTpatricia_bozza_etal_IOC_2013.pdf.txtpatricia_bozza_etal_IOC_2013.pdf.txtExtracted texttext/plain53785https://www.arca.fiocruz.br/bitstream/icict/11758/3/patricia_bozza_etal_IOC_2013.pdf.txt3240ccdca5dd8103798861d82427b68eMD53icict/117582022-06-24 12:18:54.54oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:18:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Eosinophil recruitment and activation: the role of lipid mediators
title Eosinophil recruitment and activation: the role of lipid mediators
spellingShingle Eosinophil recruitment and activation: the role of lipid mediators
Gomes, Tatiana Luna
Eosinophil
Chemotaxis
Lipid mediators
Prostaglandins
Prostaglandinas
Eosinófilo
Prostaglandinas
Leukotrienes
title_short Eosinophil recruitment and activation: the role of lipid mediators
title_full Eosinophil recruitment and activation: the role of lipid mediators
title_fullStr Eosinophil recruitment and activation: the role of lipid mediators
title_full_unstemmed Eosinophil recruitment and activation: the role of lipid mediators
title_sort Eosinophil recruitment and activation: the role of lipid mediators
author Gomes, Tatiana Luna
author_facet Gomes, Tatiana Luna
Bozza, Patrícia T.
Melo, Christiane Bandeira
author_role author
author2 Bozza, Patrícia T.
Melo, Christiane Bandeira
author2_role author
author
dc.contributor.author.fl_str_mv Gomes, Tatiana Luna
Bozza, Patrícia T.
Melo, Christiane Bandeira
dc.subject.en.pt_BR.fl_str_mv Eosinophil
Chemotaxis
Lipid mediators
Prostaglandins
Prostaglandinas
topic Eosinophil
Chemotaxis
Lipid mediators
Prostaglandins
Prostaglandinas
Eosinófilo
Prostaglandinas
Leukotrienes
dc.subject.decs.pt_BR.fl_str_mv Eosinófilo
Prostaglandinas
Leukotrienes
description Universidade Federal do Rio deJaneiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-09-21T17:25:40Z
dc.date.available.fl_str_mv 2015-09-21T17:25:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Tatiana Luna; BOZZA, Patrícia T.; MELO, Christiane Bandeira. Eosinophil recruitment and activation: the role of lipid mediators. Front. Pharmacol., v.4, n.27, Mar. 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11758
dc.identifier.issn.pt_BR.fl_str_mv 1663-4365
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fphar.2013.00027
identifier_str_mv GOMES, Tatiana Luna; BOZZA, Patrícia T.; MELO, Christiane Bandeira. Eosinophil recruitment and activation: the role of lipid mediators. Front. Pharmacol., v.4, n.27, Mar. 2013.
1663-4365
10.3389/fphar.2013.00027
url https://www.arca.fiocruz.br/handle/icict/11758
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11758/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/11758/2/patricia_bozza_etal_IOC_2013.pdf
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