Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut

Detalhes bibliográficos
Autor(a) principal: Vega-Rodriguez, Joel
Data de Publicação: 2014
Outros Autores: Ghosh, Anil K, Kanzok, Stefan M, Dinglasan, Rhoel R, Wang, Sibao, Bongio, Nicholas J, Kalume, Dario E, Miura, Kazutoyo, Long, Carole A, Pandey, Akhilesh, Lorena, Marcelo Jacobs
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10862
Resumo: Johns Hopkins University. Bloomberg School of Public Health. Malaria Research Institute. The W. Harry Feinstone Department of Molecular Microbiology and Immunology. Baltimore, MD, USA.
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spelling Vega-Rodriguez, JoelGhosh, Anil KKanzok, Stefan MDinglasan, Rhoel RWang, SibaoBongio, Nicholas JKalume, Dario EMiura, KazutoyoLong, Carole APandey, AkhileshLorena, Marcelo Jacobs2015-06-17T12:05:19Z2015-06-17T12:05:19Z2014VEGA-RODRIGUEZ, Joel et al. Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut. Proc Natl Acad Sci U S A., v.111,, n.4, p. E492–E500, jan. 2014.1091-6490https://www.arca.fiocruz.br/handle/icict/1086210.1073/pnas.1315517111engNational Academy of SciencesMultiple pathways for Plasmodium ookinete invasion of the mosquito midgutinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohns Hopkins University. Bloomberg School of Public Health. Malaria Research Institute. The W. Harry Feinstone Department of Molecular Microbiology and Immunology. Baltimore, MD, USA.Johns Hopkins University. Bloomberg School of Public Health. Malaria Research Institute. The W. Harry Feinstone Department of Molecular Microbiology and Immunology. Baltimore, MD, USA / Case Western Reserve University. Center for Global Health and Diseases. Cleveland, OH, USA.Loyola University. Department of Biology. Chicago, IL, USA.Johns Hopkins University. Bloomberg School of Public Health. Malaria Research Institute. The W. Harry Feinstone Department of Molecular Microbiology and Immunology. Baltimore, MD, USA.Chinese Academy of Sciences. Shanghai Institutes for Biological Sciences. Institute of Plant Physiology and Ecology. cKey Laboratory of Insect Developmental and Evolutionary Biology. Shangai, China.Duquesne University. Department of Biological Sciences. Pittsburgh, PA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. fLaboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. fLaboratory of Malaria and Vector Research. Rockville, MD, USA.Johns Hopkins University. The Johns Hopkins University School of Medicine. McKusick–Nathans Institute of Genetic Medicine. Departments of Biological Chemistry, Pathology, and Oncology. Baltimore, MD, USA.Johns Hopkins University. Bloomberg School of Public Health. Malaria Research Institute. The W. Harry Feinstone Department of Molecular Microbiology and Immunology. Baltimore, MD, USA.Plasmodium ookinete invasion of the mosquito midgut is a crucial step of the parasite life cycle but little is known about the molecular mechanisms involved. Previously, a phage display peptide library screen identified SM1, a peptide that binds to the mosquito midgut epithelium and inhibits ookinete invasion. SM1 was characterized as a mimotope of an ookinete surface enolase and SM1 presumably competes with enolase, the presumed ligand, for binding to a putative midgut receptor. Here we identify a mosquito midgut receptor that binds both SM1 and ookinete surface enolase, termed “enolase-binding protein” (EBP). Moreover, we determined that Plasmodium berghei parasites are heterogeneous for midgut invasion, as some parasite clones are strongly inhibited by SM1 whereas others are not. The SM1-sensitive parasites required the mosquito EBP receptor for midgut invasion whereas the SM1- resistant parasites invaded the mosquito midgut independently of EBP. These experiments provide evidence that Plasmodium ookinetes can invade the mosquito midgut by alternate pathways. Furthermore, another peptide from the original phage display screen, midgut peptide 2 (MP2), strongly inhibited midgut invasion by P. berghei (SM1-sensitive and SM1-resistant) and Plasmodium falciparum ookinetes, suggesting that MP2 binds to a separate, universal receptor for midgut invasion.PlasmodiumPlasmodium bergheiMosquitoMaláriaPlasmodium bergheiinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10862/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALdario_kalume2etal_IOC_2014.pdfapplication/pdf1677709https://www.arca.fiocruz.br/bitstream/icict/10862/2/dario_kalume2etal_IOC_2014.pdf6625aae3bddb1dfdb18a3dd1fde714e5MD52TEXTdario_kalume2etal_IOC_2014.pdf.txtdario_kalume2etal_IOC_2014.pdf.txtExtracted texttext/plain55390https://www.arca.fiocruz.br/bitstream/icict/10862/3/dario_kalume2etal_IOC_2014.pdf.txtfd328d2d0fdca73d1fb270ef2c0bb8bfMD53icict/108622022-06-24 13:12:34.668oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:12:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
title Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
spellingShingle Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
Vega-Rodriguez, Joel
Plasmodium
Plasmodium berghei
Mosquito
Malária
Plasmodium berghei
title_short Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
title_full Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
title_fullStr Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
title_full_unstemmed Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
title_sort Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut
author Vega-Rodriguez, Joel
author_facet Vega-Rodriguez, Joel
Ghosh, Anil K
Kanzok, Stefan M
Dinglasan, Rhoel R
Wang, Sibao
Bongio, Nicholas J
Kalume, Dario E
Miura, Kazutoyo
Long, Carole A
Pandey, Akhilesh
Lorena, Marcelo Jacobs
author_role author
author2 Ghosh, Anil K
Kanzok, Stefan M
Dinglasan, Rhoel R
Wang, Sibao
Bongio, Nicholas J
Kalume, Dario E
Miura, Kazutoyo
Long, Carole A
Pandey, Akhilesh
Lorena, Marcelo Jacobs
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vega-Rodriguez, Joel
Ghosh, Anil K
Kanzok, Stefan M
Dinglasan, Rhoel R
Wang, Sibao
Bongio, Nicholas J
Kalume, Dario E
Miura, Kazutoyo
Long, Carole A
Pandey, Akhilesh
Lorena, Marcelo Jacobs
dc.subject.en.pt_BR.fl_str_mv Plasmodium
Plasmodium berghei
Mosquito
topic Plasmodium
Plasmodium berghei
Mosquito
Malária
Plasmodium berghei
dc.subject.decs.pt_BR.fl_str_mv Malária
Plasmodium berghei
description Johns Hopkins University. Bloomberg School of Public Health. Malaria Research Institute. The W. Harry Feinstone Department of Molecular Microbiology and Immunology. Baltimore, MD, USA.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-17T12:05:19Z
dc.date.available.fl_str_mv 2015-06-17T12:05:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VEGA-RODRIGUEZ, Joel et al. Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut. Proc Natl Acad Sci U S A., v.111,, n.4, p. E492–E500, jan. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10862
dc.identifier.issn.pt_BR.fl_str_mv 1091-6490
dc.identifier.doi.pt_BR.fl_str_mv 10.1073/pnas.1315517111
identifier_str_mv VEGA-RODRIGUEZ, Joel et al. Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut. Proc Natl Acad Sci U S A., v.111,, n.4, p. E492–E500, jan. 2014.
1091-6490
10.1073/pnas.1315517111
url https://www.arca.fiocruz.br/handle/icict/10862
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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