L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum

Detalhes bibliográficos
Autor(a) principal: Almeida-Paes, Rodrigo
Data de Publicação: 2018
Outros Autores: Almeida-Silva, Fernando, Pinto, Gabriela Costa Maia, Almeida, Marcos de Abreu, Muniz, Mauro de Medeiros, Pizzini, Claudia Vera, Gerfen, Gary J., Nosanchuk, Joshua Daniel, Zancopé-Oliveira, Rosely Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31723
Resumo: 2020-01-31
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spelling Almeida-Paes, RodrigoAlmeida-Silva, FernandoPinto, Gabriela Costa MaiaAlmeida, Marcos de AbreuMuniz, Mauro de MedeirosPizzini, Claudia VeraGerfen, Gary J.Nosanchuk, Joshua DanielZancopé-Oliveira, Rosely Maria2019-02-19T11:33:42Z2019-02-19T11:33:42Z2018ALMEIDA-PAES, Rodrigo et al. L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum. Medical Mycology, v. 56, 506–509, 2018.1369-3786https://www.arca.fiocruz.br/handle/icict/3172310.1093/mmy/myx0681460-2709engOxford University PressL-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-31Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Albert Einstein College of Medicine. Department of Physiology and Biophysics. New York, NY, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Melanization of Histoplasma capsulatum remains poorly described, particularly in regards to the forms of melanin produced. In the present study, 30 clinical and environmental H. capsulatum strains were grown in culture media with or without L-tyrosine under conditions that produced either mycelial or yeast forms. Mycelial cultures were not melanized under the studied conditions. However, all strains cultivated under yeast conditions produced a brownish to black soluble pigment compatible with pyomelanin when grew in presence of L-tyrosine. Sulcotrione inhibited pigment production in yeast cultures, strengthening the hyphothesis that H. capsulatum yeast forms produce pyomelanin. Since pyomelanin is produced by the fungal parasitic form, this pigment may be involved in H. capsulatum virulence.Histoplasma capsulatumL-tyrosinePyomelanininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31723/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Almeida-Paes_Rodrigo _etal_INI_2018.pdfve_Almeida-Paes_Rodrigo _etal_INI_2018.pdfapplication/pdf487108https://www.arca.fiocruz.br/bitstream/icict/31723/2/ve_Almeida-Paes_Rodrigo%20_etal_INI_2018.pdfdf6d3742b3e7cae62f17f86ed9be3144MD52TEXTve_Almeida-Paes_Rodrigo _etal_INI_2018.pdf.txtve_Almeida-Paes_Rodrigo _etal_INI_2018.pdf.txtExtracted texttext/plain18065https://www.arca.fiocruz.br/bitstream/icict/31723/3/ve_Almeida-Paes_Rodrigo%20_etal_INI_2018.pdf.txt9109fbb98847d1f530e8fedb370f0896MD53icict/317232021-03-24 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dc.title.pt_BR.fl_str_mv L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
title L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
spellingShingle L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
Almeida-Paes, Rodrigo
Histoplasma capsulatum
L-tyrosine
Pyomelanin
title_short L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
title_full L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
title_fullStr L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
title_full_unstemmed L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
title_sort L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
author Almeida-Paes, Rodrigo
author_facet Almeida-Paes, Rodrigo
Almeida-Silva, Fernando
Pinto, Gabriela Costa Maia
Almeida, Marcos de Abreu
Muniz, Mauro de Medeiros
Pizzini, Claudia Vera
Gerfen, Gary J.
Nosanchuk, Joshua Daniel
Zancopé-Oliveira, Rosely Maria
author_role author
author2 Almeida-Silva, Fernando
Pinto, Gabriela Costa Maia
Almeida, Marcos de Abreu
Muniz, Mauro de Medeiros
Pizzini, Claudia Vera
Gerfen, Gary J.
Nosanchuk, Joshua Daniel
Zancopé-Oliveira, Rosely Maria
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida-Paes, Rodrigo
Almeida-Silva, Fernando
Pinto, Gabriela Costa Maia
Almeida, Marcos de Abreu
Muniz, Mauro de Medeiros
Pizzini, Claudia Vera
Gerfen, Gary J.
Nosanchuk, Joshua Daniel
Zancopé-Oliveira, Rosely Maria
dc.subject.en.pt_BR.fl_str_mv Histoplasma capsulatum
L-tyrosine
Pyomelanin
topic Histoplasma capsulatum
L-tyrosine
Pyomelanin
description 2020-01-31
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-19T11:33:42Z
dc.date.available.fl_str_mv 2019-02-19T11:33:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA-PAES, Rodrigo et al. L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum. Medical Mycology, v. 56, 506–509, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31723
dc.identifier.issn.pt_BR.fl_str_mv 1369-3786
dc.identifier.doi.none.fl_str_mv 10.1093/mmy/myx068
dc.identifier.eissn.none.fl_str_mv 1460-2709
identifier_str_mv ALMEIDA-PAES, Rodrigo et al. L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum. Medical Mycology, v. 56, 506–509, 2018.
1369-3786
10.1093/mmy/myx068
1460-2709
url https://www.arca.fiocruz.br/handle/icict/31723
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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