Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.

Detalhes bibliográficos
Autor(a) principal: Elliot, Simon Luke
Data de Publicação: 2015
Outros Autores: Rodrigues, Juliana de Oliveira, Lorenzo, Marcelo Gustavo, Martins Filho, Olindo Assis, Guarneri, Alessandra Aparecida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pntd.0003646.
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12655
Resumo: Universidade Federal de Viçosa. Departamento de Entomologia. Viçosa, MG, Brazil
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spelling Elliot, Simon LukeRodrigues, Juliana de OliveiraLorenzo, Marcelo GustavoMartins Filho, Olindo AssisGuarneri, Alessandra Aparecida2016-01-28T16:16:30Z2016-01-28T16:16:30Z2015ELLIOT, Simon Luke et al. Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner. PLoS Negl Trop Dis. Vol. 9, n. 3, p: e0003646, 2015.1935-2735https://www.arca.fiocruz.br/handle/icict/1265510.1371/journal.pntd.0003646.engPublic Library of ScienceTrypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Viçosa. Departamento de Entomologia. Viçosa, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilIt is often assumed that parasites are not virulent to their vectors. Nevertheless, parasites commonly exploit their vectors (nutritionally for example) so these can be considered a form of host. Trypanosoma cruzi, a protozoan found in mammals and triatomine bugs in the Americas, is the etiological agent of Chagas disease that affects man and domestic animals. While it has long been considered avirulent to its vectors, a few reports have indicated that it can affect triatomine fecundity. We tested whether infection imposed a temperature-dependent cost on triatomine fitness. We held infected insects at four temperatures between 21 and 30°C and measured T. cruzi growth in vitro at the same temperatures in parallel. Trypanosoma cruzi infection caused a considerable delay in the time the insects took to moult (against a background effect of temperature accelerating moult irrespective of infection status). Trypanosoma cruzi also reduced the insects' survival, but only at the intermediate temperatures of 24 and 27°C (against a background of increased mortality with increasing temperatures). Meanwhile, in vitro growth of T. cruzi increased with temperature. Our results demonstrate virulence of a protozoan agent of human disease to its insect vector under these conditions. It is of particular note that parasite-induced mortality was greatest over the range of temperatures normally preferred by these insects, probably implying adaptation of the parasite to perform well at these temperatures. Therefore we propose that triggering this delay in moulting is adaptive for the parasites, as it will delay the next bloodmeal taken by the bug, thus allowing the parasites time to develop and reach the insect rectum in order to make transmission to a new vertebrate host possible.Trypanosoma cruziChagas Diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12655/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTrypanosoma cruzi, Etiological Agent of Chagas Disease.pdfTrypanosoma cruzi, Etiological Agent of Chagas Disease.pdfapplication/pdf4968288https://www.arca.fiocruz.br/bitstream/icict/12655/2/Trypanosoma%20cruzi%2c%20Etiological%20Agent%20of%20Chagas%20Disease.pdf23a1cbef16123b01c6f28223dad17c0bMD52TEXTTrypanosoma cruzi, Etiological Agent of Chagas Disease.pdf.txtTrypanosoma 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dc.title.pt_BR.fl_str_mv Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
title Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
spellingShingle Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
Elliot, Simon Luke
Trypanosoma cruzi
Chagas Disease
title_short Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
title_full Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
title_fullStr Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
title_full_unstemmed Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
title_sort Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.
author Elliot, Simon Luke
author_facet Elliot, Simon Luke
Rodrigues, Juliana de Oliveira
Lorenzo, Marcelo Gustavo
Martins Filho, Olindo Assis
Guarneri, Alessandra Aparecida
author_role author
author2 Rodrigues, Juliana de Oliveira
Lorenzo, Marcelo Gustavo
Martins Filho, Olindo Assis
Guarneri, Alessandra Aparecida
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Elliot, Simon Luke
Rodrigues, Juliana de Oliveira
Lorenzo, Marcelo Gustavo
Martins Filho, Olindo Assis
Guarneri, Alessandra Aparecida
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chagas Disease
topic Trypanosoma cruzi
Chagas Disease
description Universidade Federal de Viçosa. Departamento de Entomologia. Viçosa, MG, Brazil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-01-28T16:16:30Z
dc.date.available.fl_str_mv 2016-01-28T16:16:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ELLIOT, Simon Luke et al. Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner. PLoS Negl Trop Dis. Vol. 9, n. 3, p: e0003646, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12655
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0003646.
identifier_str_mv ELLIOT, Simon Luke et al. Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner. PLoS Negl Trop Dis. Vol. 9, n. 3, p: e0003646, 2015.
1935-2735
10.1371/journal.pntd.0003646.
url https://www.arca.fiocruz.br/handle/icict/12655
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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