Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria

Detalhes bibliográficos
Autor(a) principal: Mendonça, Vitor Rosa Ramos de
Data de Publicação: 2012
Outros Autores: Luz, Nívea Farias, Santos, Nadja de Jesus Gonçalves dos, Borges, Valeria de Matos, Gonçalves, Marilda de Souza, Andrade, Bruno de Bezerril, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7939
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
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spelling Mendonça, Vitor Rosa Ramos deLuz, Nívea FariasSantos, Nadja de Jesus Gonçalves dosBorges, Valeria de MatosGonçalves, Marilda de SouzaAndrade, Bruno de BezerrilBarral Netto, Manoel2014-07-14T12:34:54Z2014-07-14T12:34:54Z2012MENDONÇA, V. R. R. et al. Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Infection and Immunity, v. 80, n. 4, p. 1445-1154, 2012.1098-5522https://www.arca.fiocruz.br/handle/icict/793910.1128/IAI.05933-11engAmerican Society for MicrobiologyAssociation between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Immunobiology Section. Laboratory of Parasitic Diseases. Bethesda, Maryland, USAeFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT). São Paulo, SP, BrasilIntravascular hemolysis is a hallmark event in the immunopathology of malaria that results in increased systemic concentrations of free hemoglobin (Hb). The oxidation of Hb by free radicals causes the release of heme, which amplifies inflammation. To circumvent the detrimental effects of free heme, hosts have developed several homeostatic mechanisms, including the enzyme haptoglobin (Hp), which scavenges cell-free Hb, the monocyte receptor CD163, which binds to Hb-Hp complexes, and heme oxygenase-1 (HO-1), which degrades intracellular free heme. We tested the association between these three main components of the host response to hemolysis and susceptibility to malaria in a Brazilian population. The genetic profiles of the HMOX1 and Hp genes and the plasma levels of a serum inflammatory marker, the soluble form of the CD163 receptor (sCD163), were studied in 264 subjects, including 78 individuals with symptomatic malaria, 106 individuals with asymptomatic malaria, and 80 uninfected individuals. We found that long (GT)n repeats in the microsatellite polymorphism region of the HMOX1 gene, the Hp2 allele, and the Hp2.2 genotype were associated with symptomatic malaria. Moreover, increased plasma concentrations of heme, Hp, HO-1, and sCD163 were associated with susceptibility to malaria. The validation of these results could support the development of targeted therapies and aid in reducing the severity of malariaAntígenos CD/sangueAntígenos de Diferenciação Mielomonocítica/sangueHaptoglobinas/genéticaHeme Oxigenase-1/genéticaMalária/genéticaMalária/imunologiaReceptores de Superfície Celular/sangueAdultoAlelosBrasilSuscetibilidade a DoençasFemininoHaptoglobinas/metabolismoHeme/metabolismoHeme Oxigenase-1/metabolismoHemoglobinas/metabolismoHumanosMasculinoRepetições de MicrossatélitesMeia-IdadePolimorfismo Genéticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMendonça VRR and Association between....pdfMendonça VRR and Association between....pdfapplication/pdf1483842https://www.arca.fiocruz.br/bitstream/icict/7939/1/Mendon%c3%a7a%20VRR%20and%20Association%20between....pdf789494313a7e9e5c126a3356d3e09691MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7939/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMendonça VRR and Association between....pdf.txtMendonça VRR and Association between....pdf.txtExtracted texttext/plain58533https://www.arca.fiocruz.br/bitstream/icict/7939/3/Mendon%c3%a7a%20VRR%20and%20Association%20between....pdf.txted13d156ff40fdc5786649696b686d31MD53icict/79392023-03-15 14:33:17.929oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
title Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
spellingShingle Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
Mendonça, Vitor Rosa Ramos de
Antígenos CD/sangue
Antígenos de Diferenciação Mielomonocítica/sangue
Haptoglobinas/genética
Heme Oxigenase-1/genética
Malária/genética
Malária/imunologia
Receptores de Superfície Celular/sangue
Adulto
Alelos
Brasil
Suscetibilidade a Doenças
Feminino
Haptoglobinas/metabolismo
Heme/metabolismo
Heme Oxigenase-1/metabolismo
Hemoglobinas/metabolismo
Humanos
Masculino
Repetições de Microssatélites
Meia-Idade
Polimorfismo Genético
title_short Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
title_full Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
title_fullStr Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
title_full_unstemmed Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
title_sort Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
author Mendonça, Vitor Rosa Ramos de
author_facet Mendonça, Vitor Rosa Ramos de
Luz, Nívea Farias
Santos, Nadja de Jesus Gonçalves dos
Borges, Valeria de Matos
Gonçalves, Marilda de Souza
Andrade, Bruno de Bezerril
Barral Netto, Manoel
author_role author
author2 Luz, Nívea Farias
Santos, Nadja de Jesus Gonçalves dos
Borges, Valeria de Matos
Gonçalves, Marilda de Souza
Andrade, Bruno de Bezerril
Barral Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendonça, Vitor Rosa Ramos de
Luz, Nívea Farias
Santos, Nadja de Jesus Gonçalves dos
Borges, Valeria de Matos
Gonçalves, Marilda de Souza
Andrade, Bruno de Bezerril
Barral Netto, Manoel
dc.subject.decs.pt_BR.fl_str_mv Antígenos CD/sangue
Antígenos de Diferenciação Mielomonocítica/sangue
Haptoglobinas/genética
Heme Oxigenase-1/genética
Malária/genética
Malária/imunologia
Receptores de Superfície Celular/sangue
Adulto
Alelos
Brasil
Suscetibilidade a Doenças
Feminino
Haptoglobinas/metabolismo
Heme/metabolismo
Heme Oxigenase-1/metabolismo
Hemoglobinas/metabolismo
Humanos
Masculino
Repetições de Microssatélites
Meia-Idade
Polimorfismo Genético
topic Antígenos CD/sangue
Antígenos de Diferenciação Mielomonocítica/sangue
Haptoglobinas/genética
Heme Oxigenase-1/genética
Malária/genética
Malária/imunologia
Receptores de Superfície Celular/sangue
Adulto
Alelos
Brasil
Suscetibilidade a Doenças
Feminino
Haptoglobinas/metabolismo
Heme/metabolismo
Heme Oxigenase-1/metabolismo
Hemoglobinas/metabolismo
Humanos
Masculino
Repetições de Microssatélites
Meia-Idade
Polimorfismo Genético
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-14T12:34:54Z
dc.date.available.fl_str_mv 2014-07-14T12:34:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDONÇA, V. R. R. et al. Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Infection and Immunity, v. 80, n. 4, p. 1445-1154, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7939
dc.identifier.issn.none.fl_str_mv 1098-5522
dc.identifier.doi.none.fl_str_mv 10.1128/IAI.05933-11
identifier_str_mv MENDONÇA, V. R. R. et al. Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Infection and Immunity, v. 80, n. 4, p. 1445-1154, 2012.
1098-5522
10.1128/IAI.05933-11
url https://www.arca.fiocruz.br/handle/icict/7939
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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