Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?

Detalhes bibliográficos
Autor(a) principal: Chagas, Cristiano Aparecido
Data de Publicação: 2006
Outros Autores: Endo, Luiza Hayashi, dosSantos, Washington Luis Conrado, Pinto, Glauce Aparecida, Sakano, Eulália, Brousset, Pierre, Vassallo, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7660
Resumo: State University of Campinas (UNICAMP). Laboratory of Experimental Pathology. Centro de Assistência Integral à Saúde da Mulher. São Paulo, SP, Brasil
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spelling Chagas, Cristiano AparecidoEndo, Luiza HayashidosSantos, Washington Luis ConradoPinto, Glauce AparecidaSakano, EuláliaBrousset, PierreVassallo, José2014-05-28T16:28:46Z2014-05-28T16:28:46Z2006CHAGAS, C. A. et al. Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues? International Journal of Pediatric Otorhinolaryngology, v. 70, p. 1923—1927, 2006.0165-5876https://www.arca.fiocruz.br/handle/icict/766010.1016/j.ijporl.2006.06.020engElsevierIs there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleState University of Campinas (UNICAMP). Laboratory of Experimental Pathology. Centro de Assistência Integral à Saúde da Mulher. São Paulo, SP, BrasilFaculty of Medical Sciences. Department of Otorhinolaryngology. UNICAMP. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilState University of Campinas (UNICAMP). Laboratory of Experimental Pathology. Centro de Assistência Integral à Saúde da Mulher. São Paulo, SP, BrasilFaculty of Medical Sciences. Department of Otorhinolaryngology. UNICAMP. São Paulo, SP, BrasilUniversity of Toulouse. Laboratory of Pathology. Toulouse, FranceFaculty of Medical Sciences, UNICAMP. Department of Anatomical Pathology. Campinas, SP, BrasilOBJECTIVE: Human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) are human pathogens associated to a number of neoplasms, including tumors of the Waldeyer's ring. Both viruses have been previously detected by in situ methods in tonsils and adenoids from children. HHV-8 was found in 6.8% of the cases and EBV in about one third of the cases. As they belong to the same gamma-herpesvirus subfamily and share some biological characteristics, it is of medical interest to further explore their possible relationship in the Waldeyer's ring, an issue not yet addressed in the specialized literature. The purpose of the present study is to compare the presence of EBV by in situ hybridization (ISH) in tonsils and adenoids from children up to 14 years of age in cases previously shown to be positive and negative for HHV-8. METHODS: Paraffin wax-embedded sections consisting of 38 tonsils and two adenoids from 40 patients were analyzed. HHV-8 was detected by ISH, using the T1-1 probe for the viral mRNA. EBV was also detected by ISH, using the EBER probe. Both probes and the detection systems were provided by Novocastra. RESULTS: HHV-8 was detected in 19 tonsils and one adenoid. The other 19 tonsils and one adenoid taken from the HHV-8-negative group were selected by pairing age and gender of patients with the HHV-8-positive group. In both groups EBV was detected in 13 cases and was negative in other 7. CONCLUSION: Although both viruses are related in many aspects, some biological and epidemiological features differ. This is reflected in the present results, as EBV is similarly detected in the groups negative and positive for HHV-8, favoring different mechanisms of spread.Human herpesvirus 8Epstein—Barr virusTonsilsAdenoidsIn situ hybridizationTonsila Faríngea/virologiaHerpesvirus Humano 4/isolamento & purificaçãoTonsila Palatina/virologiaTonsila Faríngea/químicaAdolescenteCriançaPré-EscolarDNA Viral/análiseFemininoHumanosHibridização In SituLactenteMasculinoTonsila Palatina/químicaInclusão em Parafinainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALChagas CA Is tehre a relationship....pdfChagas CA Is tehre a relationship....pdfapplication/pdf434460https://www.arca.fiocruz.br/bitstream/icict/7660/1/Chagas%20CA%20Is%20tehre%20a%20relationship....pdf3d20fc70e8b3fd2c9aae2d2ae2a3722fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7660/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTChagas CA Is tehre a relationship....pdf.txtChagas CA Is tehre a relationship....pdf.txtExtracted texttext/plain19002https://www.arca.fiocruz.br/bitstream/icict/7660/5/Chagas%20CA%20Is%20tehre%20a%20relationship....pdf.txt8e33938c24dd787636298101f4b5014bMD55THUMBNAILChagas CA Is tehre a relationship....pdf.jpgChagas CA Is tehre a relationship....pdf.jpgGenerated Thumbnailimage/jpeg2262https://www.arca.fiocruz.br/bitstream/icict/7660/4/Chagas%20CA%20Is%20tehre%20a%20relationship....pdf.jpg8070ca0b2e122735c49d322dc67043adMD54icict/76602023-03-15 14:33:22.188oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
title Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
spellingShingle Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
Chagas, Cristiano Aparecido
Human herpesvirus 8
Epstein—Barr virus
Tonsils
Adenoids
In situ hybridization
Tonsila Faríngea/virologia
Herpesvirus Humano 4/isolamento & purificação
Tonsila Palatina/virologia
Tonsila Faríngea/química
Adolescente
Criança
Pré-Escolar
DNA Viral/análise
Feminino
Humanos
Hibridização In Situ
Lactente
Masculino
Tonsila Palatina/química
Inclusão em Parafina
title_short Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
title_full Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
title_fullStr Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
title_full_unstemmed Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
title_sort Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
author Chagas, Cristiano Aparecido
author_facet Chagas, Cristiano Aparecido
Endo, Luiza Hayashi
dosSantos, Washington Luis Conrado
Pinto, Glauce Aparecida
Sakano, Eulália
Brousset, Pierre
Vassallo, José
author_role author
author2 Endo, Luiza Hayashi
dosSantos, Washington Luis Conrado
Pinto, Glauce Aparecida
Sakano, Eulália
Brousset, Pierre
Vassallo, José
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chagas, Cristiano Aparecido
Endo, Luiza Hayashi
dosSantos, Washington Luis Conrado
Pinto, Glauce Aparecida
Sakano, Eulália
Brousset, Pierre
Vassallo, José
dc.subject.en.pt_BR.fl_str_mv Human herpesvirus 8
Epstein—Barr virus
Tonsils
Adenoids
In situ hybridization
topic Human herpesvirus 8
Epstein—Barr virus
Tonsils
Adenoids
In situ hybridization
Tonsila Faríngea/virologia
Herpesvirus Humano 4/isolamento & purificação
Tonsila Palatina/virologia
Tonsila Faríngea/química
Adolescente
Criança
Pré-Escolar
DNA Viral/análise
Feminino
Humanos
Hibridização In Situ
Lactente
Masculino
Tonsila Palatina/química
Inclusão em Parafina
dc.subject.decs.pt_BR.fl_str_mv Tonsila Faríngea/virologia
Herpesvirus Humano 4/isolamento & purificação
Tonsila Palatina/virologia
Tonsila Faríngea/química
Adolescente
Criança
Pré-Escolar
DNA Viral/análise
Feminino
Humanos
Hibridização In Situ
Lactente
Masculino
Tonsila Palatina/química
Inclusão em Parafina
description State University of Campinas (UNICAMP). Laboratory of Experimental Pathology. Centro de Assistência Integral à Saúde da Mulher. São Paulo, SP, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2014-05-28T16:28:46Z
dc.date.available.fl_str_mv 2014-05-28T16:28:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAGAS, C. A. et al. Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues? International Journal of Pediatric Otorhinolaryngology, v. 70, p. 1923—1927, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7660
dc.identifier.issn.none.fl_str_mv 0165-5876
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijporl.2006.06.020
identifier_str_mv CHAGAS, C. A. et al. Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues? International Journal of Pediatric Otorhinolaryngology, v. 70, p. 1923—1927, 2006.
0165-5876
10.1016/j.ijporl.2006.06.020
url https://www.arca.fiocruz.br/handle/icict/7660
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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