Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48770 |
Resumo: | a Universidade Regional do Cariri, URCA, Cel Ant^onio Luis, 1161, 63105-000, Pimenta, Crato, CE, Brazil b Universidade Federal do Paran a, UFPR, XV de Novembro, 1299, 80.060-000, Centro, Curitiba, PR, Brazil c Universidade Regional de Blumenau, FURB, Ant^onio da Veiga, 140, 89030-903, Itoupava Seca, Blumenau, SC, Brazil d Laborat orio de investiga¸c~ao em Gen etica e Hematologia Translacional, Instituto Gon¸calo Moniz (IGM), Funda¸c~ao Oswaldo Cruz (FIOCRUZ), Salvador, BA 40296- 710, Brazil e Centro Universit ario Doutor Le~ao Sampaio (Unile~ao), Av. Maria Letícia Leite Pereira s/n, Lagoa Seca, Juazeiro do Norte, Brazil |
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Braga, Ana LaysCruz, Rafael Pereira daCarneiro, Joara Nalyda PereiraSantos, Antonia Thassya Lucas dosSales, Debora LimaBezerra, Camila FonsecaFonseca, Victor Juno AlencarRocha, Janaina EsmeraldoFreitas, Thiago Sampaio deCampina, Fabia FerreiraCosta, Maria do SocorroAmaral, Wanderlei doRebelo, Ricardo AndradeSilva, Luiz Everson daRibeiro Filho, JaimeCoutinho, Henrique Douglas MeloRodriguese, Fabíola Fernandes GalvãoBraga, Maria Flaviana Bezerra Morais2021-08-26T18:58:04Z2021-08-26T18:58:04Z2021BRAGA, Ana Lays et al. Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance. South African Journal of Botany, 2021.0254-6299https://www.arca.fiocruz.br/handle/icict/4877010.1016/j.sajb.2021.07.017a Universidade Regional do Cariri, URCA, Cel Ant^onio Luis, 1161, 63105-000, Pimenta, Crato, CE, Brazil b Universidade Federal do Paran a, UFPR, XV de Novembro, 1299, 80.060-000, Centro, Curitiba, PR, Brazil c Universidade Regional de Blumenau, FURB, Ant^onio da Veiga, 140, 89030-903, Itoupava Seca, Blumenau, SC, Brazil d Laborat orio de investiga¸c~ao em Gen etica e Hematologia Translacional, Instituto Gon¸calo Moniz (IGM), Funda¸c~ao Oswaldo Cruz (FIOCRUZ), Salvador, BA 40296- 710, Brazil e Centro Universit ario Doutor Le~ao Sampaio (Unile~ao), Av. Maria Letícia Leite Pereira s/n, Lagoa Seca, Juazeiro do Norte, Brazil"Múltipla ver em Notas"Plant-derived essential oils are volatile hydrophobic compounds with significant antimicrobial activities. Considering the rise of antimicrobial resistance, these natural products have been highlighted as efficient weapons against multidrug-resistant microorganisms. This work aimed to investigate the phytochemical composition and antimicrobial activity of Piper regnellii essential oil against strains of Escherichia coli, Staphylococcus aureus, Candida albicans, and Candida tropicalis. Phytochemical analysis was performed through gas chromatography coupled with mass spectrometry (CG/MS). The intrinsic antimicrobial activity and the ability of the essential oil to modulate antimicrobial resistance were assessed using the broth microdilution method. Fungal virulence inhibition was analyzed by measuring the growth of hyphae in microculture chambers. Phytochemical characterization revealed a predominance of phenylpropanoids, including apiol (70.79%) and dilapiol (15.05%) as major constituents. While presenting clinically ineffective antibacterial effects (MIC 1.024 mg/mL for all strains), the essential oil potentiated the activity of gentamicin against E. coli at concentrations above 20 mg/mL. Piper regnellii essential oil showed clinically ineffective antifungal activity with IC50 values above 500 mg/mL. However, it was found to potentiate the activity of fluconazole against C. tropicalis at concentrations ranging from 32 mg/mL to 1024 mg/mL. Furthermore, the morphological transition was inhibited by culturing C. albicans and C. tropicalis with different concentrations of the essential oil. Together, our results indicate that P. regnellii essential oil presents promising antifungal effects. However, the mechanisms underlying its interference on Candida virulence remain to be further investigated.engElsevierPiper regnelliiEscherichia coliFluconazolCandida tropicalisResistência antimicrobianaPiper regnelliiEssential oilAntifungalCandida virulenceAntimicrobial resistancePiper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48770/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALBraga, Ana Lays Piper regnelli....pdfBraga, Ana Lays Piper regnelli....pdfapplication/pdf948023https://www.arca.fiocruz.br/bitstream/icict/48770/2/Braga%2c%20Ana%20Lays%20Piper%20regnelli....pdfa6b5ebc8f9e27fefb83aa954235d5affMD52TEXTBraga, Ana Lays Piper regnelli....pdf.txtBraga, Ana Lays Piper regnelli....pdf.txtExtracted texttext/plain42782https://www.arca.fiocruz.br/bitstream/icict/48770/3/Braga%2c%20Ana%20Lays%20Piper%20regnelli....pdf.txt2b07af8631f4f05dc5fbbcd2808820e1MD53icict/487702023-03-15 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| dc.title.pt_BR.fl_str_mv |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance |
| title |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance |
| spellingShingle |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance Braga, Ana Lays Piper regnellii Escherichia coli Fluconazol Candida tropicalis Resistência antimicrobiana Piper regnellii Essential oil Antifungal Candida virulence Antimicrobial resistance |
| title_short |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance |
| title_full |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance |
| title_fullStr |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance |
| title_full_unstemmed |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance |
| title_sort |
Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance |
| author |
Braga, Ana Lays |
| author_facet |
Braga, Ana Lays Cruz, Rafael Pereira da Carneiro, Joara Nalyda Pereira Santos, Antonia Thassya Lucas dos Sales, Debora Lima Bezerra, Camila Fonseca Fonseca, Victor Juno Alencar Rocha, Janaina Esmeraldo Freitas, Thiago Sampaio de Campina, Fabia Ferreira Costa, Maria do Socorro Amaral, Wanderlei do Rebelo, Ricardo Andrade Silva, Luiz Everson da Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Rodriguese, Fabíola Fernandes Galvão Braga, Maria Flaviana Bezerra Morais |
| author_role |
author |
| author2 |
Cruz, Rafael Pereira da Carneiro, Joara Nalyda Pereira Santos, Antonia Thassya Lucas dos Sales, Debora Lima Bezerra, Camila Fonseca Fonseca, Victor Juno Alencar Rocha, Janaina Esmeraldo Freitas, Thiago Sampaio de Campina, Fabia Ferreira Costa, Maria do Socorro Amaral, Wanderlei do Rebelo, Ricardo Andrade Silva, Luiz Everson da Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Rodriguese, Fabíola Fernandes Galvão Braga, Maria Flaviana Bezerra Morais |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Braga, Ana Lays Cruz, Rafael Pereira da Carneiro, Joara Nalyda Pereira Santos, Antonia Thassya Lucas dos Sales, Debora Lima Bezerra, Camila Fonseca Fonseca, Victor Juno Alencar Rocha, Janaina Esmeraldo Freitas, Thiago Sampaio de Campina, Fabia Ferreira Costa, Maria do Socorro Amaral, Wanderlei do Rebelo, Ricardo Andrade Silva, Luiz Everson da Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Rodriguese, Fabíola Fernandes Galvão Braga, Maria Flaviana Bezerra Morais |
| dc.subject.other.pt_BR.fl_str_mv |
Piper regnellii Escherichia coli Fluconazol Candida tropicalis Resistência antimicrobiana |
| topic |
Piper regnellii Escherichia coli Fluconazol Candida tropicalis Resistência antimicrobiana Piper regnellii Essential oil Antifungal Candida virulence Antimicrobial resistance |
| dc.subject.en.pt_BR.fl_str_mv |
Piper regnellii Essential oil Antifungal Candida virulence Antimicrobial resistance |
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a Universidade Regional do Cariri, URCA, Cel Ant^onio Luis, 1161, 63105-000, Pimenta, Crato, CE, Brazil b Universidade Federal do Paran a, UFPR, XV de Novembro, 1299, 80.060-000, Centro, Curitiba, PR, Brazil c Universidade Regional de Blumenau, FURB, Ant^onio da Veiga, 140, 89030-903, Itoupava Seca, Blumenau, SC, Brazil d Laborat orio de investiga¸c~ao em Gen etica e Hematologia Translacional, Instituto Gon¸calo Moniz (IGM), Funda¸c~ao Oswaldo Cruz (FIOCRUZ), Salvador, BA 40296- 710, Brazil e Centro Universit ario Doutor Le~ao Sampaio (Unile~ao), Av. Maria Letícia Leite Pereira s/n, Lagoa Seca, Juazeiro do Norte, Brazil |
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2021 |
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2021-08-26T18:58:04Z |
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2021-08-26T18:58:04Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BRAGA, Ana Lays et al. Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance. South African Journal of Botany, 2021. |
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https://www.arca.fiocruz.br/handle/icict/48770 |
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0254-6299 |
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10.1016/j.sajb.2021.07.017 |
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BRAGA, Ana Lays et al. Piper regnellii (Miq.) C. DC.: Chemical composition, antimicrobial effects, and modulation of antimicrobial resistance. South African Journal of Botany, 2021. 0254-6299 10.1016/j.sajb.2021.07.017 |
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Elsevier |
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