Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.

Detalhes bibliográficos
Autor(a) principal: Lemos, Queli Teixeira
Data de Publicação: 2003
Outros Autores: Santos, Isis Fernandes Magalhães, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/3822
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BAa, Brasil.
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spelling Lemos, Queli TeixeiraSantos, Isis Fernandes MagalhãesAndrade, Zilton de Araújo2012-03-28T21:50:46Z2012-03-28T21:50:46Z2003LEMOS, Q. T.; SANTOS, I. F. M.; ANDRADE, Z. AImmunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats. Brazilian Journal of Medical Biological Research, v. 36, n. 9, p. 1201-1207, Sept. 2003.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/3822engImmunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BAa, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Rats infected with the helminth Capillaria hepatica regularly develop septal fibrosis of the liver similar to that induced by repeated ip injections of pig serum. Fibrosis starts when the focal parasitic lesions begin to show signs of resorption, thus suggesting an immunologically mediated pathogenesis of this fibrosis. To explore this possibility, the development of C. hepatica-related hepatic fibrosis was observed in rats exposed to worm antigens from the first neonatal day onward. Wistar rats (150 g) were either injected ip with an extract of C. hepatica eggs (protein concentration: 1 mg/ml) or received immature eggs by gavage from the first neonatal day until adult life and were then infected with 500 embryonated eggs. Changes were monitored on the basis of serum levels of anti-worm antibodies and hepatic histopathology. Rats submitted to immunological oral tolerance markedly suppressed C. hepatica-related serum antibodies and septal fibrosis of the liver when infected with the helminth later on. Tolerance trials with ip injections of worm antigens gave essentially negative results. The partial suppression of septal fibrosis of the liver after the induction of immunological tolerance to C. hepatica antigens in rats indicates an immunological basis for the fibrosis and emphasizes the importance of immunological factors in the pathogenesis of hepatic fibrosis.Capillaria Hepatica ModelHepatic FibrosisImmunological ToleranceAntígenos de HelmintosCapillariaInfecções por EnoplidaCirrose Hepática ExperimentalHepatopatias ParasitáriasAnticorpos Anti-HelmínticosCirrose Hepática ExperimentalRatos Wistarinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLemos QT Immunological basis of septal ....pdfLemos QT Immunological basis of septal ....pdfapplication/pdf1144530https://www.arca.fiocruz.br/bitstream/icict/3822/1/Lemos%20QT%20Immunological%20basis%20of%20septal%20....pdf3a8cc5fff97bca572f9fc9f7e6e01e6dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3822/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTLemos QT Immunological basis of septal ....pdf.txtLemos QT Immunological basis of septal ....pdf.txtExtracted texttext/plain23291https://www.arca.fiocruz.br/bitstream/icict/3822/5/Lemos%20QT%20Immunological%20basis%20of%20septal%20....pdf.txt3f80b256dec431733206dd858742748cMD55THUMBNAILLemos QT Immunological basis of septal ....pdf.jpgLemos QT Immunological basis of septal ....pdf.jpgGenerated Thumbnailimage/jpeg1959https://www.arca.fiocruz.br/bitstream/icict/3822/4/Lemos%20QT%20Immunological%20basis%20of%20septal%20....pdf.jpgb602017a17e3da6b3f6d0c964dc8790bMD54icict/38222023-03-15 14:33:01.615oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
title Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
spellingShingle Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
Lemos, Queli Teixeira
Capillaria Hepatica Model
Hepatic Fibrosis
Immunological Tolerance
Antígenos de Helmintos
Capillaria
Infecções por Enoplida
Cirrose Hepática Experimental
Hepatopatias Parasitárias
Anticorpos Anti-Helmínticos
Cirrose Hepática Experimental
Ratos Wistar
title_short Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
title_full Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
title_fullStr Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
title_full_unstemmed Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
title_sort Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
author Lemos, Queli Teixeira
author_facet Lemos, Queli Teixeira
Santos, Isis Fernandes Magalhães
Andrade, Zilton de Araújo
author_role author
author2 Santos, Isis Fernandes Magalhães
Andrade, Zilton de Araújo
author2_role author
author
dc.contributor.author.fl_str_mv Lemos, Queli Teixeira
Santos, Isis Fernandes Magalhães
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Capillaria Hepatica Model
Hepatic Fibrosis
Immunological Tolerance
topic Capillaria Hepatica Model
Hepatic Fibrosis
Immunological Tolerance
Antígenos de Helmintos
Capillaria
Infecções por Enoplida
Cirrose Hepática Experimental
Hepatopatias Parasitárias
Anticorpos Anti-Helmínticos
Cirrose Hepática Experimental
Ratos Wistar
dc.subject.decs.pt_BR.fl_str_mv Antígenos de Helmintos
Capillaria
Infecções por Enoplida
Cirrose Hepática Experimental
Hepatopatias Parasitárias
Anticorpos Anti-Helmínticos
Cirrose Hepática Experimental
Ratos Wistar
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BAa, Brasil.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2012-03-28T21:50:46Z
dc.date.available.fl_str_mv 2012-03-28T21:50:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEMOS, Q. T.; SANTOS, I. F. M.; ANDRADE, Z. AImmunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats. Brazilian Journal of Medical Biological Research, v. 36, n. 9, p. 1201-1207, Sept. 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/3822
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv LEMOS, Q. T.; SANTOS, I. F. M.; ANDRADE, Z. AImmunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats. Brazilian Journal of Medical Biological Research, v. 36, n. 9, p. 1201-1207, Sept. 2003.
0100-879X
url https://www.arca.fiocruz.br/handle/icict/3822
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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