Distinct patterns of microvasculature in the cutaneous lesions of leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2000 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5870 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil/ Universidade de Nova Iguaçu. Nova Iguaçu, RJ, Brasil |
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Antunes, Sérgio Luiz GomesMota, Ester MariaAlmeida, Sonia Maria Rocha deGallo, Maria EugeniaNery, José Augusto da CostaLenzi, Henrique Leonel2012-11-26T15:20:30Z2012-11-26T15:20:30Z2000ANTUNES, S. L. G. Et al. Distinct patterns of microvasculature in the cutaneous lesion of leprosy. International Journal of Leprosy and other Mycobacterial Diseases, v. 68, n.2, p. 143-151, 2000.1148-916Xhttps://www.arca.fiocruz.br/handle/icict/5870engDistinct patterns of microvasculature in the cutaneous lesions of leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil/ Universidade de Nova Iguaçu. Nova Iguaçu, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilThis work is an investigation on the microvasculature of the cutaneous infiltrates of leprosy with the immunohistochemical staining of endothelial cells in cutaneous biopsies. Anti-Factor VIII-related antigen antibody (anti-FVIII-ra) and Ulex Europaeus-1 lectin (UEA-1) binding were utilized as endothelial cell markers. Thirty-nine patients grouped according to the Ridley-Jopling classification (14 borderline tuberculoid, 18 borderline lepromatous, 6 lepromatous, and 1 indeterminate leprosy) were selected for this study. Two microvascular architectural patterns could be clearly distinguished: lepromatous lesions presented a dense and tortuous mesh of microvessels among the Mycobacterium leprae-glutted macrophages; whereas the microvessels in the tuberculoid lesions were restricted to the periphery of the granulomas and were not seen among the central epithelioid cells. We were able to distinguish three basic morphological kinds of infiltrate distribution related to the microvessels: micronodules, cords and macronodules. Intensifications of the FVIII-ra immunoreactivity and UEA-1 binding capacity were observed in the endothelial cells of microvessels involved by the inflammatory infiltrate. A distinct cytokine expression profile at the leprosy poles and the role of mast cells in angiogenesis were speculated as factors contributing to these distinct patterns. Growth of the lesion and systemic dissemination of M. leprae in the bipolar spectrum of leprosy may hypothetically be influenced by the vascular-infiltrate relationship. The detection of angiogenesis in the cutaneous lesions of leprosy may bring about alternate and/or additional strategies for leprosy treatment.cutaneous lesionsleprosyanti-FVIII-raEuropaeus-1 lectinMycobacterium lepraeimmunohistochemicalBiópsiaEndotélioGranulomaImunoistoquímicaHanseníase VirchowianaHanseníase TuberculóideFator de von WillebrandPele, irrigação sanguíneainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5870/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTDistinct Patterns of Microvasculature in theCutaneous Lesions of Leprosy'.pdf.txtDistinct Patterns of Microvasculature in theCutaneous Lesions of Leprosy'.pdf.txtExtracted texttext/plain25112https://www.arca.fiocruz.br/bitstream/icict/5870/3/Distinct%20Patterns%20of%20Microvasculature%20in%20theCutaneous%20Lesions%20of%20Leprosy%27.pdf.txtfc3fe7ede87a20308575743264d235b9MD53Distinct.pdf.txtDistinct.pdf.txtExtracted texttext/plain25235https://www.arca.fiocruz.br/bitstream/icict/5870/8/Distinct.pdf.txtd16092a592cce73db5030a7f62216b58MD58THUMBNAILDistinct Patterns of Microvasculature in theCutaneous Lesions of Leprosy'.pdf.jpgDistinct Patterns of Microvasculature in theCutaneous Lesions of Leprosy'.pdf.jpgGenerated Thumbnailimage/jpeg1855https://www.arca.fiocruz.br/bitstream/icict/5870/4/Distinct%20Patterns%20of%20Microvasculature%20in%20theCutaneous%20Lesions%20of%20Leprosy%27.pdf.jpg6f9e98c31aa0625a4a6ac5ced6f318e2MD54Distinct.pdf.jpgDistinct.pdf.jpgGenerated Thumbnailimage/jpeg1855https://www.arca.fiocruz.br/bitstream/icict/5870/7/Distinct.pdf.jpg6f9e98c31aa0625a4a6ac5ced6f318e2MD57ORIGINALDistinct.pdfDistinct.pdfapplication/pdf9601548https://www.arca.fiocruz.br/bitstream/icict/5870/5/Distinct.pdf900cc8e99fca8d6adf61d54fcb63005eMD55icict/58702023-09-05 10:02:18.406oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:02:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy |
| title |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy |
| spellingShingle |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy Antunes, Sérgio Luiz Gomes cutaneous lesions leprosy anti-FVIII-ra Europaeus-1 lectin Mycobacterium leprae immunohistochemical Biópsia Endotélio Granuloma Imunoistoquímica Hanseníase Virchowiana Hanseníase Tuberculóide Fator de von Willebrand Pele, irrigação sanguínea |
| title_short |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy |
| title_full |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy |
| title_fullStr |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy |
| title_full_unstemmed |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy |
| title_sort |
Distinct patterns of microvasculature in the cutaneous lesions of leprosy |
| author |
Antunes, Sérgio Luiz Gomes |
| author_facet |
Antunes, Sérgio Luiz Gomes Mota, Ester Maria Almeida, Sonia Maria Rocha de Gallo, Maria Eugenia Nery, José Augusto da Costa Lenzi, Henrique Leonel |
| author_role |
author |
| author2 |
Mota, Ester Maria Almeida, Sonia Maria Rocha de Gallo, Maria Eugenia Nery, José Augusto da Costa Lenzi, Henrique Leonel |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Antunes, Sérgio Luiz Gomes Mota, Ester Maria Almeida, Sonia Maria Rocha de Gallo, Maria Eugenia Nery, José Augusto da Costa Lenzi, Henrique Leonel |
| dc.subject.en.pt_BR.fl_str_mv |
cutaneous lesions leprosy anti-FVIII-ra Europaeus-1 lectin Mycobacterium leprae immunohistochemical |
| topic |
cutaneous lesions leprosy anti-FVIII-ra Europaeus-1 lectin Mycobacterium leprae immunohistochemical Biópsia Endotélio Granuloma Imunoistoquímica Hanseníase Virchowiana Hanseníase Tuberculóide Fator de von Willebrand Pele, irrigação sanguínea |
| dc.subject.decs.pt_BR.fl_str_mv |
Biópsia Endotélio Granuloma Imunoistoquímica Hanseníase Virchowiana Hanseníase Tuberculóide Fator de von Willebrand Pele, irrigação sanguínea |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil/ Universidade de Nova Iguaçu. Nova Iguaçu, RJ, Brasil |
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2000 |
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2000 |
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2012-11-26T15:20:30Z |
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2012-11-26T15:20:30Z |
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info:eu-repo/semantics/article |
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article |
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ANTUNES, S. L. G. Et al. Distinct patterns of microvasculature in the cutaneous lesion of leprosy. International Journal of Leprosy and other Mycobacterial Diseases, v. 68, n.2, p. 143-151, 2000. |
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https://www.arca.fiocruz.br/handle/icict/5870 |
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1148-916X |
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ANTUNES, S. L. G. Et al. Distinct patterns of microvasculature in the cutaneous lesion of leprosy. International Journal of Leprosy and other Mycobacterial Diseases, v. 68, n.2, p. 143-151, 2000. 1148-916X |
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