The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43194 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. |
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Moragas-Tellis, Carla JunqueiraSouza, Fernando AlmeidaChagas, Maria do Socorro dos SantosSouza, Paulo Victor Ramos deSilva, João Victor SilvaRamos, Ygor JesséMoreira, Davyson de LimaCalabrese, Kátia da SilvaBehrens, Maria Dutra2020-09-05T19:50:05Z2020-09-05T19:50:05Z2020MORAGAS-TELLIS, Carla Junqueira et al. The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes. Molecules, v. 23, n. 3547, p. 1-13, 2020.1420-3049https://www.arca.fiocruz.br/handle/icict/4319410.3390/molecules25153547engMDPILeishmania amazonensisBignoniaceaeAntocianinasEstação do anoPerfil fitoquímicoBignoniaceaeLeishmania amazonensisAnthocyanidinsPhytochemical profileSeasonCarajurinBignoniaceaeAnthocyanidinsThe Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Maranhão. Pós Graduação em Ciência Animal. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos- armanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.Arrabidaea chica Verlot (crajiru) is a plant used in folk medicine as an astringent, anti-inflammatory, wound healing and to treat fungal and viral diseases such as measles chickenpox and herpes. Arrabidaea chica has several morphotypes recognized but little is known about its chemical variability. In the present study the anthocyanidin profile of A. chica morphotypes collected in two seasons (summer and winter) have been examined and their activity against Leishmania infection compared. High-performance liquid chromatography coupled to a diode-array detector (HPLC-DAD-UV) and by tandem mass spectrometry with electrospray ionization (ESI-MS/MS) were used for anthocyanidin separation and identification. Antileishmanial activity was measured against promastigote forms of Leishmania amazonensis. Multivariate analysis, principal component analysis (PCA) and Pearson’s correlation were performed to classify morphotypes accordingly to their anthocyanidin profile. The presence of 6,7,30 ,40 -tetrahydroxy-5-methoxyflavylium (30 -hydroxycarajurone) (1), carajurone (2), 6,7,30 -trihydroxy-5,40 -dimethoxy-flavylium (30 -hydroxy-carajurin) (3) and carajurin (4), and three unidentified anthocyanidins were detected. Two different groups were recognized: group I containing 30 -hydroxy-carajurone; and group II with high content of carajurin. Among anthocyanidins identified in the extracts, only carajurin showed significant statistical correlation (p = 0.030) with activity against L. amazonensis. Carajurin could thus be considered as a pharmacological marker for the antileishmanial potential of the species.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43194/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFernandoASouza_KatiaCalabrese_etal_IOC_2020.pdfFernandoASouza_KatiaCalabrese_etal_IOC_2020.pdfapplication/pdf1711820https://www.arca.fiocruz.br/bitstream/icict/43194/2/FernandoASouza_KatiaCalabrese_etal_IOC_2020.pdf7f4c9f4ed396a3951623b6bed5a38029MD52TEXTFernandoASouza_KatiaCalabrese_etal_IOC_2020.pdf.txtFernandoASouza_KatiaCalabrese_etal_IOC_2020.pdf.txtExtracted texttext/plain53587https://www.arca.fiocruz.br/bitstream/icict/43194/3/FernandoASouza_KatiaCalabrese_etal_IOC_2020.pdf.txt3837374a05ad23f2af83cbe53ed54d71MD53icict/431942022-06-24 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| dc.title.pt_BR.fl_str_mv |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes |
| title |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes |
| spellingShingle |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes Moragas-Tellis, Carla Junqueira Leishmania amazonensis Bignoniaceae Antocianinas Estação do ano Perfil fitoquímico Bignoniaceae Leishmania amazonensis Anthocyanidins Phytochemical profile Season Carajurin Bignoniaceae Anthocyanidins |
| title_short |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes |
| title_full |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes |
| title_fullStr |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes |
| title_full_unstemmed |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes |
| title_sort |
The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes |
| author |
Moragas-Tellis, Carla Junqueira |
| author_facet |
Moragas-Tellis, Carla Junqueira Souza, Fernando Almeida Chagas, Maria do Socorro dos Santos Souza, Paulo Victor Ramos de Silva, João Victor Silva Ramos, Ygor Jessé Moreira, Davyson de Lima Calabrese, Kátia da Silva Behrens, Maria Dutra |
| author_role |
author |
| author2 |
Souza, Fernando Almeida Chagas, Maria do Socorro dos Santos Souza, Paulo Victor Ramos de Silva, João Victor Silva Ramos, Ygor Jessé Moreira, Davyson de Lima Calabrese, Kátia da Silva Behrens, Maria Dutra |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Moragas-Tellis, Carla Junqueira Souza, Fernando Almeida Chagas, Maria do Socorro dos Santos Souza, Paulo Victor Ramos de Silva, João Victor Silva Ramos, Ygor Jessé Moreira, Davyson de Lima Calabrese, Kátia da Silva Behrens, Maria Dutra |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania amazonensis Bignoniaceae Antocianinas Estação do ano Perfil fitoquímico |
| topic |
Leishmania amazonensis Bignoniaceae Antocianinas Estação do ano Perfil fitoquímico Bignoniaceae Leishmania amazonensis Anthocyanidins Phytochemical profile Season Carajurin Bignoniaceae Anthocyanidins |
| dc.subject.en.pt_BR.fl_str_mv |
Bignoniaceae Leishmania amazonensis Anthocyanidins Phytochemical profile Season Carajurin |
| dc.subject.decs.pt_BR.fl_str_mv |
Bignoniaceae Anthocyanidins |
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Fundação Oswaldo Cruz. Instituto de Tecnologia de Fármacos-Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-09-05T19:50:05Z |
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2020-09-05T19:50:05Z |
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2020 |
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info:eu-repo/semantics/article |
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MORAGAS-TELLIS, Carla Junqueira et al. The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes. Molecules, v. 23, n. 3547, p. 1-13, 2020. |
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https://www.arca.fiocruz.br/handle/icict/43194 |
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1420-3049 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/molecules25153547 |
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MORAGAS-TELLIS, Carla Junqueira et al. The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes. Molecules, v. 23, n. 3547, p. 1-13, 2020. 1420-3049 10.3390/molecules25153547 |
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