Antitubercular activity of new coumarins

Detalhes bibliográficos
Autor(a) principal: Cardoso, Silvia H.
Data de Publicação: 2011
Outros Autores: Barreto, Milena B., Lourenço, Maria C. S., Henriques, Maria das Graças M. de O., Candéa, André L. P., Kaiser, Carlos R., Souza, Marcus V. N. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36960
Resumo: 2020-11-08
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spelling Cardoso, Silvia H.Barreto, Milena B.Lourenço, Maria C. S.Henriques, Maria das Graças M. de O.Candéa, André L. P.Kaiser, Carlos R.Souza, Marcus V. N. de2019-11-08T14:57:48Z2019-11-08T14:57:48Z2011CARDOSO, Silvia H. et al. Antitubercular activity of new coumarins. Chemical Biology and Drug Design, v. 77, p. 489-493, 2011.1747-0277https://www.arca.fiocruz.br/handle/icict/3696010.1111/j.1747-0285.2011.01120.x1747-0285engWileyAntitubercular activity of new coumarinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-08Universidade Federal de Alagoas. Campus Arapiraca. Arapiraca, AL, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.The present article describes a series of 21 N ¢-benzylidene-2-oxo-2H-chromene-3-carbohydrazides 4a–4v, which were synthesized and evaluated for their cell viabilities in non-infected and Mycobacterium bovis Bacillus Calmette–Guerin-infected macrophages. Subsequently, the non-cytotoxic compounds 4c, 4g, 4h, 4j, 4l and 4t were assessed against Mycobacterium tuberculosis ATCC 27294 using the microplate Alamar Blue assay and the activity expressed as the minimum inhibitory concentration in lg/mL. These compounds exhibited a significant activity (50–100 lg/mL) when compared to the first-line drugs, such as pyrazinamide (PZA >100 lg/mL). These results could be considered a good starting point for further studies to develop new lead compounds to treat multidrug-resistant tuberculosis.CoumarinsDrugsN'-acylhydrazonesTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36960/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cardoso_Silvia_etal_INI_2011.pdfve_Cardoso_Silvia_etal_INI_2011.pdfapplication/pdf175731https://www.arca.fiocruz.br/bitstream/icict/36960/2/ve_Cardoso_Silvia_etal_INI_2011.pdf64b8c35df6418d4ac4e43a1c74369ff0MD52TEXTve_Cardoso_Silvia_etal_INI_2011.pdf.txtve_Cardoso_Silvia_etal_INI_2011.pdf.txtExtracted texttext/plain22027https://www.arca.fiocruz.br/bitstream/icict/36960/3/ve_Cardoso_Silvia_etal_INI_2011.pdf.txt748d3aa75862810e633c871fea8b70d4MD53icict/369602021-03-24 16:32:38.591oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Antitubercular activity of new coumarins
title Antitubercular activity of new coumarins
spellingShingle Antitubercular activity of new coumarins
Cardoso, Silvia H.
Coumarins
Drugs
N'-acylhydrazones
Tuberculosis
title_short Antitubercular activity of new coumarins
title_full Antitubercular activity of new coumarins
title_fullStr Antitubercular activity of new coumarins
title_full_unstemmed Antitubercular activity of new coumarins
title_sort Antitubercular activity of new coumarins
author Cardoso, Silvia H.
author_facet Cardoso, Silvia H.
Barreto, Milena B.
Lourenço, Maria C. S.
Henriques, Maria das Graças M. de O.
Candéa, André L. P.
Kaiser, Carlos R.
Souza, Marcus V. N. de
author_role author
author2 Barreto, Milena B.
Lourenço, Maria C. S.
Henriques, Maria das Graças M. de O.
Candéa, André L. P.
Kaiser, Carlos R.
Souza, Marcus V. N. de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Silvia H.
Barreto, Milena B.
Lourenço, Maria C. S.
Henriques, Maria das Graças M. de O.
Candéa, André L. P.
Kaiser, Carlos R.
Souza, Marcus V. N. de
dc.subject.en.pt_BR.fl_str_mv Coumarins
Drugs
N'-acylhydrazones
Tuberculosis
topic Coumarins
Drugs
N'-acylhydrazones
Tuberculosis
description 2020-11-08
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-11-08T14:57:48Z
dc.date.available.fl_str_mv 2019-11-08T14:57:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDOSO, Silvia H. et al. Antitubercular activity of new coumarins. Chemical Biology and Drug Design, v. 77, p. 489-493, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36960
dc.identifier.issn.pt_BR.fl_str_mv 1747-0277
dc.identifier.doi.none.fl_str_mv 10.1111/j.1747-0285.2011.01120.x
dc.identifier.eissn.none.fl_str_mv 1747-0285
identifier_str_mv CARDOSO, Silvia H. et al. Antitubercular activity of new coumarins. Chemical Biology and Drug Design, v. 77, p. 489-493, 2011.
1747-0277
10.1111/j.1747-0285.2011.01120.x
1747-0285
url https://www.arca.fiocruz.br/handle/icict/36960
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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