Role of alternative polyadenylation during adipogenic differentiation: an in silico approach

Detalhes bibliográficos
Autor(a) principal: Spangenberg, Lucia
Data de Publicação: 2013
Outros Autores: Dominguez, Alejandro Correa, Dallagiovanna, Bruno, Naya, Hugo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16017
Resumo: Ministério da Saúde and Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico-CNPq, FIOCRUZ, Pasteur Research Program and Fundação Araucaria.
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spelling Spangenberg, LuciaDominguez, Alejandro CorreaDallagiovanna, BrunoNaya, Hugo2016-09-30T17:12:37Z2016-09-30T17:12:37Z2013SPANGENBERG, Lucia et al. Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. PLoS ONE, v. 8, n. 10, p. 1-13, 2013.1932-6203https://www.arca.fiocruz.br/handle/icict/1601710.1371/journal.pone.0075578Ministério da Saúde and Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico-CNPq, FIOCRUZ, Pasteur Research Program and Fundação Araucaria.Institut Pasteur Montevideo. Bioinformatics Unit. Montevideo, Uruguay.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Institut Pasteur Montevideo. Bioinformatics Unit. Montevideo, Uruguay / Universidad de la República. Facultad de Agronomía. Departamento de Producción Animal y Pasturas. Montevideo, Uruguay.Post-transcriptional regulation of stem cell differentiation is far from being completely understood. Changes in protein levels are not fully correlated with corresponding changes in mRNAs; the observed differences might be partially explained by post-transcriptional regulation mechanisms, such as alternative polyadenylation. This would involve changes in protein binding, transcript usage, miRNAs and other non-coding RNAs. In the present work we analyzed the distribution of alternative transcripts during adipogenic differentiation and the potential role of miRNAs in post-transcriptional regulation. Our in silico analysis suggests a modest, consistent, bias in 3′UTR lengths during differentiation enabling a fine-tuned transcript regulation via small non-coding RNAs. Including these effects in the analyses partially accounts for the observed discrepancies in relative abundance of protein and mRNA.engIratxe PueblaRole of alternative polyadenylation during adipogenic differentiation: an in silico approachinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAlternative PolyadenylationAdipogenic DifferentiationMesenchymal stem cellsPoliadenilaçãoDiferenciação CelularCélulas Mesenquimais Estromaisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/16017/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALRole of Alternative Polyadenylation.PDFRole of Alternative Polyadenylation.PDFapplication/pdf1471326https://www.arca.fiocruz.br/bitstream/icict/16017/2/Role%20of%20Alternative%20Polyadenylation.PDF47d98f08daf86f85e991bc001adcce80MD52TEXTRole of Alternative Polyadenylation.PDF.txtRole of Alternative Polyadenylation.PDF.txtExtracted texttext/plain68532https://www.arca.fiocruz.br/bitstream/icict/16017/3/Role%20of%20Alternative%20Polyadenylation.PDF.txt6dd1129dacc387c6785710a66dc15183MD53icict/160172022-10-20 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dc.title.pt_BR.fl_str_mv Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
title Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
spellingShingle Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
Spangenberg, Lucia
Alternative Polyadenylation
Adipogenic Differentiation
Mesenchymal stem cells
Poliadenilação
Diferenciação Celular
Células Mesenquimais Estromais
title_short Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
title_full Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
title_fullStr Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
title_full_unstemmed Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
title_sort Role of alternative polyadenylation during adipogenic differentiation: an in silico approach
author Spangenberg, Lucia
author_facet Spangenberg, Lucia
Dominguez, Alejandro Correa
Dallagiovanna, Bruno
Naya, Hugo
author_role author
author2 Dominguez, Alejandro Correa
Dallagiovanna, Bruno
Naya, Hugo
author2_role author
author
author
dc.contributor.author.fl_str_mv Spangenberg, Lucia
Dominguez, Alejandro Correa
Dallagiovanna, Bruno
Naya, Hugo
dc.subject.en.pt_BR.fl_str_mv Alternative Polyadenylation
Adipogenic Differentiation
Mesenchymal stem cells
topic Alternative Polyadenylation
Adipogenic Differentiation
Mesenchymal stem cells
Poliadenilação
Diferenciação Celular
Células Mesenquimais Estromais
dc.subject.decs.pt_BR.fl_str_mv Poliadenilação
Diferenciação Celular
Células Mesenquimais Estromais
description Ministério da Saúde and Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico-CNPq, FIOCRUZ, Pasteur Research Program and Fundação Araucaria.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2016-09-30T17:12:37Z
dc.date.available.fl_str_mv 2016-09-30T17:12:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SPANGENBERG, Lucia et al. Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. PLoS ONE, v. 8, n. 10, p. 1-13, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16017
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pone.0075578
identifier_str_mv SPANGENBERG, Lucia et al. Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. PLoS ONE, v. 8, n. 10, p. 1-13, 2013.
1932-6203
10.1371/journal.pone.0075578
url https://www.arca.fiocruz.br/handle/icict/16017
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Iratxe Puebla
publisher.none.fl_str_mv Iratxe Puebla
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16017/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/16017/2/Role%20of%20Alternative%20Polyadenylation.PDF
https://www.arca.fiocruz.br/bitstream/icict/16017/3/Role%20of%20Alternative%20Polyadenylation.PDF.txt
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