Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization

Detalhes bibliográficos
Autor(a) principal: Souza, Denise Andréa Silva de
Data de Publicação: 2018
Outros Autores: Pavoni, Daniela Parada, Krieger, Marco Aurélio, Ludwig, Adriana
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31696
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.
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spelling Souza, Denise Andréa Silva dePavoni, Daniela ParadaKrieger, Marco AurélioLudwig, Adriana2019-02-15T18:18:59Z2019-02-15T18:18:59Z2018SOUZA, Denise Andréa Silva de et al. Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization. Scientific Reports, v. 8, n. 1376, p. 1-11, 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/3169610.1038/s41598-017-18865-yporNature ResearchKinetoplastidaTrypanosoma cruziMyosinsEvolutionMolecularEvolución MolecularMiosinasTrypanosomatinaEvolução MolecularEvolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil. / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Myosins are motor proteins that comprise a large and diversified family important for a broad range of functions. Two myosin classes, I and XIII, were previously assigned in Trypanosomatids, based mainly on the studies of Trypanosoma cruzi, T. brucei and Leishmania major, and important human pathogenic species; seven orphan myosins were identified in T. cruzi. Our results show that the great variety of T. cruzi myosins is also present in some closely related species and in Bodo saltans, a member of an early divergent branch of Kinetoplastida. Therefore, these myosins should no longer be considered "orphans". We proposed the classification of a kinetoplastid-specific myosin group into a new class, XXXVI. Moreover, our phylogenetic data suggest that a great repertoire of myosin genes was present in the last common ancestor of trypanosomatids and B. saltans, mainly resulting from several gene duplications. These genes have since been predominantly maintained in synteny in some species, and secondary losses explain the current distribution. We also found two interesting genes that were clearly derived from myosin genes, demonstrating that possible redundant or useless genes, instead of simply being lost, can serve as raw material for the evolution of new genes and functions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/31696/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALs41598-017-188.pdfs41598-017-188.pdfapplication/pdf5208060https://www.arca.fiocruz.br/bitstream/icict/31696/2/s41598-017-188.pdf284ab473d765391a581c2ad147ddbd1aMD52TEXTs41598-017-188.pdf.txts41598-017-188.pdf.txtExtracted texttext/plain56024https://www.arca.fiocruz.br/bitstream/icict/31696/3/s41598-017-188.pdf.txt079f7cd79e39f948774e6dbca015b052MD53icict/316962019-02-17 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dc.title.pt_BR.fl_str_mv Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
title Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
spellingShingle Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
Souza, Denise Andréa Silva de
Kinetoplastida
Trypanosoma cruzi
Myosins
Evolution
Molecular
Evolución Molecular
Miosinas
Trypanosomatina
Evolução Molecular
title_short Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
title_full Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
title_fullStr Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
title_full_unstemmed Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
title_sort Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization
author Souza, Denise Andréa Silva de
author_facet Souza, Denise Andréa Silva de
Pavoni, Daniela Parada
Krieger, Marco Aurélio
Ludwig, Adriana
author_role author
author2 Pavoni, Daniela Parada
Krieger, Marco Aurélio
Ludwig, Adriana
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza, Denise Andréa Silva de
Pavoni, Daniela Parada
Krieger, Marco Aurélio
Ludwig, Adriana
dc.subject.other.pt_BR.fl_str_mv Kinetoplastida
topic Kinetoplastida
Trypanosoma cruzi
Myosins
Evolution
Molecular
Evolución Molecular
Miosinas
Trypanosomatina
Evolução Molecular
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Myosins
Evolution
Molecular
dc.subject.es.pt_BR.fl_str_mv Evolución Molecular
dc.subject.decs.pt_BR.fl_str_mv Miosinas
Trypanosomatina
Evolução Molecular
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-15T18:18:59Z
dc.date.available.fl_str_mv 2019-02-15T18:18:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Denise Andréa Silva de et al. Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization. Scientific Reports, v. 8, n. 1376, p. 1-11, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31696
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-017-18865-y
identifier_str_mv SOUZA, Denise Andréa Silva de et al. Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization. Scientific Reports, v. 8, n. 1376, p. 1-11, 2018.
2045-2322
10.1038/s41598-017-18865-y
url https://www.arca.fiocruz.br/handle/icict/31696
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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