Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20059 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil |
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Costa, Maria Fernanda LimaMacinko, JamesMambrini, Juliana Vaz de MeloPeixoto, Sérgio William VianaPereira, Alexandre da CostaTarazona, Eduardo MartinsRibeiro, Antonio Luiz Pinho2017-07-12T17:54:37Z2017-07-12T17:54:37Z2016COSTA, Maria Fernanda Lima et al. Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. PLOS Neglected Tropical Diseases, v. 10, n. 5. Art. e0004724, 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/2005910.1371/journal.pntd.0004724engPublic Library of ScienceeletrocardiogramaTrypanosoma cruziElectrocardiographyTrypanosoma cruziNative AmericansSocioeconomic aspects of healthCholesterolCardiomyopathiesCohort studiesCoronary heart diseaseGenomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aginginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversity of California. Fielding School of Public Health. Departments of Health Policy and Management and Community Health Sciences. Los Angeles, CA, United States of AmericaFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade de São Paulo. Instituto do Coração. São Paulo, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, BrazilBackground: The influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown. Methodology/Principal Findings: We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged ≥ 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association. Conclusions/Significance: Our findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/20059/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALGenomic African and Native.pdfGenomic African and Native.pdfapplication/pdf4943341https://www.arca.fiocruz.br/bitstream/icict/20059/2/Genomic%20African%20and%20Native.pdf62be9fa597f74c0aab87fee60ab3c752MD52TEXTGenomic African and Native.pdf.txtGenomic African and Native.pdf.txtExtracted texttext/plain298https://www.arca.fiocruz.br/bitstream/icict/20059/3/Genomic%20African%20and%20Native.pdf.txtd7480274db210d97d84f67ba9983518cMD53icict/200592019-06-19 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| dc.title.pt_BR.fl_str_mv |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging |
| title |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging |
| spellingShingle |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging Costa, Maria Fernanda Lima eletrocardiograma Trypanosoma cruzi Electrocardiography Trypanosoma cruzi Native Americans Socioeconomic aspects of health Cholesterol Cardiomyopathies Cohort studies Coronary heart disease |
| title_short |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging |
| title_full |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging |
| title_fullStr |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging |
| title_full_unstemmed |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging |
| title_sort |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging |
| author |
Costa, Maria Fernanda Lima |
| author_facet |
Costa, Maria Fernanda Lima Macinko, James Mambrini, Juliana Vaz de Melo Peixoto, Sérgio William Viana Pereira, Alexandre da Costa Tarazona, Eduardo Martins Ribeiro, Antonio Luiz Pinho |
| author_role |
author |
| author2 |
Macinko, James Mambrini, Juliana Vaz de Melo Peixoto, Sérgio William Viana Pereira, Alexandre da Costa Tarazona, Eduardo Martins Ribeiro, Antonio Luiz Pinho |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Maria Fernanda Lima Macinko, James Mambrini, Juliana Vaz de Melo Peixoto, Sérgio William Viana Pereira, Alexandre da Costa Tarazona, Eduardo Martins Ribeiro, Antonio Luiz Pinho |
| dc.subject.other.pt_BR.fl_str_mv |
eletrocardiograma Trypanosoma cruzi |
| topic |
eletrocardiograma Trypanosoma cruzi Electrocardiography Trypanosoma cruzi Native Americans Socioeconomic aspects of health Cholesterol Cardiomyopathies Cohort studies Coronary heart disease |
| dc.subject.en.pt_BR.fl_str_mv |
Electrocardiography Trypanosoma cruzi Native Americans Socioeconomic aspects of health Cholesterol Cardiomyopathies Cohort studies Coronary heart disease |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil |
| publishDate |
2016 |
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2016 |
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2017-07-12T17:54:37Z |
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2017-07-12T17:54:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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COSTA, Maria Fernanda Lima et al. Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. PLOS Neglected Tropical Diseases, v. 10, n. 5. Art. e0004724, 2016. |
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https://www.arca.fiocruz.br/handle/icict/20059 |
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1935-2727 |
| dc.identifier.eissn.none.fl_str_mv |
10.1371/journal.pntd.0004724 |
| identifier_str_mv |
COSTA, Maria Fernanda Lima et al. Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. PLOS Neglected Tropical Diseases, v. 10, n. 5. Art. e0004724, 2016. 1935-2727 10.1371/journal.pntd.0004724 |
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eng |
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