Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Camilla Rodrigues de Almeida
Data de Publicação: 2021
Outros Autores: Almeida, Nathalia Alves Araújo de, Martinelli, Katrini Guidolini, Pires, Marcia Amendola, Mello, Carlos Eduardo Brandao, Barros, José J., Paula, Vanessa Salete de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1186/s12985-021-01487-2
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49101
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Ribeiro, Camilla Rodrigues de AlmeidaAlmeida, Nathalia Alves Araújo deMartinelli, Katrini GuidoliniPires, Marcia AmendolaMello, Carlos Eduardo BrandaoBarros, José J.Paula, Vanessa Salete de2021-09-17T12:43:06Z2021-09-17T12:43:06Z2021RIBEIRO, Camilla Rodrigues de Almeida et al. Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients. Virology Journal, v. 18, n. 15, 11 p, 2021.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/4910110.1186/s12985-021-01487-2engBMCInfecção por hepatite B ocultaCitocinasCo-infecção do HBV/HCVOccult hepatitis B infectionCytokinesHBV/HCV co-infectionCytokine profle during occult hepatitis B virus infection in chronic hepatitis C patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espirito Santo. Vitória, ES, BrasilUniversidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Ambulatório de Doenças do Fígado. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Ambulatório de Doenças do Fígado. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Background: The hepatitis B virus (HBV) is one of the leading causes of acute, chronic and occult hepatitis (OBI) representing a serious public health threat. Cytokines are known to be important chemical mediators that regulate the diferentiation, proliferation and function of immune cells. Accumulating evidence indicate that the inadequate immune responses are responsible for HBV persistency. The aim of this study were to investigate the cytokines IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10 and IL-17A in patients with OBI and verify if there is an association between the levels of these cytokines with the determination of clinical courses during HBV occult infection. Methods: 114 patients with chronic hepatitis C were investigated through serological and molecular tests, the OBI coinfected patients were subjected to the test for cytokines using the commercial human CBA kit. As controls, ten healthy donors with no history of liver disease and 10 chronic HBV monoinfected patients of similar age to OBI patients were selected. Results: Among 114 HCV patients investigated, 11 individuals had occult hepatitis B. The levels of cytokines were heterogeneous between the groups, most of the cytokines showed higher levels of production detection among OBI/HCV individuals when compared to control group and HBV monoinfected pacients. We found a high level of IL 17A in the HBV monoinfected group, high levels of TNF-α, IL-10, IL-6, IL-4 and IL-2 in OBI/HCV patients. Conclusion: These cytokines could be involved in the persistence of HBV DNA in hepatocytes triggers a constant immune response, inducing continuous liver infammation, which can accelerate liver damage and favor the develop ment of liver cirrhosis in other chronic liver diseases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49101/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCamilaRibeiro_JoseBarros_etal_IOC_2021.pdfCamilaRibeiro_JoseBarros_etal_IOC_2021.pdfapplication/pdf928919https://www.arca.fiocruz.br/bitstream/icict/49101/2/CamilaRibeiro_JoseBarros_etal_IOC_2021.pdfd6dec3dc12c997e81420ae6c34c6f5d0MD52icict/491012021-09-17 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dc.title.pt_BR.fl_str_mv Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
title Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
spellingShingle Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
Ribeiro, Camilla Rodrigues de Almeida
Infecção por hepatite B oculta
Citocinas
Co-infecção do HBV/HCV
Occult hepatitis B infection
Cytokines
HBV/HCV co-infection
title_short Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
title_full Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
title_fullStr Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
title_full_unstemmed Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
title_sort Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients
author Ribeiro, Camilla Rodrigues de Almeida
author_facet Ribeiro, Camilla Rodrigues de Almeida
Almeida, Nathalia Alves Araújo de
Martinelli, Katrini Guidolini
Pires, Marcia Amendola
Mello, Carlos Eduardo Brandao
Barros, José J.
Paula, Vanessa Salete de
author_role author
author2 Almeida, Nathalia Alves Araújo de
Martinelli, Katrini Guidolini
Pires, Marcia Amendola
Mello, Carlos Eduardo Brandao
Barros, José J.
Paula, Vanessa Salete de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Camilla Rodrigues de Almeida
Almeida, Nathalia Alves Araújo de
Martinelli, Katrini Guidolini
Pires, Marcia Amendola
Mello, Carlos Eduardo Brandao
Barros, José J.
Paula, Vanessa Salete de
dc.subject.other.pt_BR.fl_str_mv Infecção por hepatite B oculta
Citocinas
Co-infecção do HBV/HCV
topic Infecção por hepatite B oculta
Citocinas
Co-infecção do HBV/HCV
Occult hepatitis B infection
Cytokines
HBV/HCV co-infection
dc.subject.en.pt_BR.fl_str_mv Occult hepatitis B infection
Cytokines
HBV/HCV co-infection
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-17T12:43:06Z
dc.date.available.fl_str_mv 2021-09-17T12:43:06Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO, Camilla Rodrigues de Almeida et al. Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients. Virology Journal, v. 18, n. 15, 11 p, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49101
dc.identifier.issn.pt_BR.fl_str_mv 1743-422X
dc.identifier.doi.none.fl_str_mv 10.1186/s12985-021-01487-2
identifier_str_mv RIBEIRO, Camilla Rodrigues de Almeida et al. Cytokine profle during occult hepatitis B virus infection in chronic hepatitis C patients. Virology Journal, v. 18, n. 15, 11 p, 2021.
1743-422X
10.1186/s12985-021-01487-2
url https://www.arca.fiocruz.br/handle/icict/49101
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49101/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49101/2/CamilaRibeiro_JoseBarros_etal_IOC_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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