Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?

Lana, Marta de; Martins Filho, Olindo Assis

Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?

Detalhes bibliográficos
Autor(a) principal:	Lana, Marta de
Data de Publicação:	2015
Outros Autores:	Martins Filho, Olindo Assis
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/13438
Resumo:	Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil / Universidade Federal de Ouro Preto. Escola de Farmácia. Programas de Pós-Graduação em Ciências Biológicas (Núcleo de Pesquisas em Ciências Biológicas (NUPEB)) e Ciências Farmacêuticas (CiPHARMA). Ouro Preto, MG, Brasil

Metadados do item

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repository_id_str	2135
spelling	Lana, Marta deMartins Filho, Olindo Assis2016-04-01T18:11:50Z2016-04-01T18:11:50Z2015Lana, Marta de; Martins Filho, Olindo Assis. Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts? BioMed Research International, Vol. 2015, Article ID 652985, 2015.2314-6141https://www.arca.fiocruz.br/handle/icict/1343810.1155/2015/652985engHindawi Publishing CorporationRevisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil / Universidade Federal de Ouro Preto. Escola de Farmácia. Programas de Pós-Graduação em Ciências Biológicas (Núcleo de Pesquisas em Ciências Biológicas (NUPEB)) e Ciências Farmacêuticas (CiPHARMA). Ouro Preto, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilOne of the most relevant issues beyond the effectiveness of etiological treatment of Chagas disease is the lack of consensual/feasible tools to identify and certify the definitive parasitological cure. Several methods of distinct natures (parasitological, serological, and molecular) have been continuously proposed and novel perspectives are currently under investigation. Although the simultaneous use of distinct tests may offer better contributions and advances, it also leads to controversies of interpretation, with lack of mutual consent of cure criterion amongst researchers and physicians. In fact, when distinct host compartments (blood/tissues) are evaluated and explored, novel questions may arise due to the nature and sensitivity limit of each test. This short analytical review intends to present a chronological and critical overview and discuss the state-of-the-art distinct devices available for post therapeutic cure assessment in Chagas disease, their contributions, meanings, and interpretation, aiming to point out the major gaps and propose novel insight for future perspectives of post therapeutic management of Chagas disease patients.Chagas diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13438/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRevisiting the Posttherapeutic Cure Criterion in Chagas Disease.pdfRevisiting the Posttherapeutic Cure Criterion in Chagas Disease.pdfapplication/pdf613698https://www.arca.fiocruz.br/bitstream/icict/13438/2/Revisiting%20the%20Posttherapeutic%20Cure%20Criterion%20in%20Chagas%20Disease.pdf300ebc68ae524409b26d23371abab691MD52TEXTRevisiting the Posttherapeutic Cure Criterion in Chagas Disease.pdf.txtRevisiting the Posttherapeutic Cure Criterion in Chagas Disease.pdf.txtExtracted texttext/plain62141https://www.arca.fiocruz.br/bitstream/icict/13438/3/Revisiting%20the%20Posttherapeutic%20Cure%20Criterion%20in%20Chagas%20Disease.pdf.txte7163dd790a4715f9af2b58ceba93a92MD53icict/134382019-06-19 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dc.title.pt_BR.fl_str_mv	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
title	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
spellingShingle	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts? Lana, Marta de Chagas disease
title_short	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
title_full	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
title_fullStr	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
title_full_unstemmed	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
title_sort	Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
author	Lana, Marta de
author_facet	Lana, Marta de Martins Filho, Olindo Assis
author_role	author
author2	Martins Filho, Olindo Assis
author2_role	author
dc.contributor.author.fl_str_mv	Lana, Marta de Martins Filho, Olindo Assis
dc.subject.en.pt_BR.fl_str_mv	Chagas disease
topic	Chagas disease
description	Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil / Universidade Federal de Ouro Preto. Escola de Farmácia. Programas de Pós-Graduação em Ciências Biológicas (Núcleo de Pesquisas em Ciências Biológicas (NUPEB)) e Ciências Farmacêuticas (CiPHARMA). Ouro Preto, MG, Brasil
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2016-04-01T18:11:50Z
dc.date.available.fl_str_mv	2016-04-01T18:11:50Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	Lana, Marta de; Martins Filho, Olindo Assis. Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts? BioMed Research International, Vol. 2015, Article ID 652985, 2015.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/13438
dc.identifier.issn.none.fl_str_mv	2314-6141
dc.identifier.doi.none.fl_str_mv	10.1155/2015/652985
identifier_str_mv	Lana, Marta de; Martins Filho, Olindo Assis. Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts? BioMed Research International, Vol. 2015, Article ID 652985, 2015. 2314-6141 10.1155/2015/652985
url	https://www.arca.fiocruz.br/handle/icict/13438
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Hindawi Publishing Corporation
publisher.none.fl_str_mv	Hindawi Publishing Corporation
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?

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