Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system

Detalhes bibliográficos
Autor(a) principal: Elias, Flávia Tavares Silva
Data de Publicação: 2015
Outros Autores: Silva, Everton Nunes da, Belfort, Rubens, Silva, Marcus Tolentino, Atallah, Álvaro Nagib
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40369
Resumo: Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.
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spelling Elias, Flávia Tavares SilvaSilva, Everton Nunes daBelfort, RubensSilva, Marcus TolentinoAtallah, Álvaro Nagib2020-03-18T12:49:58Z2020-03-18T12:49:58Z2015ELIAS, Flávia Tavares Silva et al. Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system. PLoS ONE, San Francisco, v. 10, n. 10, oct. 2015. 10 p.1932-6203https://www.arca.fiocruz.br/handle/icict/4036910.1371/journal.pone.0139556engUniversity of Miami School of Medicine. Bascom Palmer Eye InstituteMacular DegenerationMacular degenerationCosts and cost analysisPublic healthDegeneração MacularCustos e Análise de CustoSaúde PúblicaTreatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health systeminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.University of Brasilia, Brasília, DF, Brazil.Federal University of São Paulo, São Paulo, SP, Brazil.Federal University of Amazonas, Manaus, AM, Brazil.Federal University of São Paulo, São Paulo, SP, Brazil.Background Age-related macular degeneration (AMD) is a disease that causes reduced visual acuity and blindness. The new treatment options for AMD are not provided by the Brazilian public health system. Objective To conduct a budget impact analysis of three scenarios for the introduction of AMD treatments: all the medications (verteporfin, ranibizumab, and bevacizumab–the reference scenario), ranibizumab alone, and bevacizumab alone. Methods The basic assumption was that the Brazilian public health system would treat the entire target population with AMD aged > 70 years between 2008 and 2011. The size of the population of interest was estimated from official population projections and the prevalence of the disease was obtained from a systematic review. Medication prices were estimated by weighting their market values with correction factors to take account of the public procurement policy. The possibility of aliquoting bevacizumab was also considered. A panel of experts was consulted to estimate the market share of the different medications for the reference scenario. The incremental costs of the ranibizumab-alone and bevacizumab-alone scenarios compared to the reference scenario were calculated. Univariate sensitivity analyses were run to check the robustness of the model. Results In four years, the Brazilian public health system would have treated 1,136,349 individuals with AMD. The annual costs of treating one patient would have been US$476.65 for bevacizumab, US$11,469.39 for ranibizumab, and US$4,376.28 for verteporfin. The incremental cost of the ranibizumab-alone scenario would have been US$1,878,318,056.00 in four years, while the incremental cost for the bevacizumab-alone scenario would have been a reduction of US$4,978,326,359.00 (i.e., a cost saving) in the same period. The bevacizumab-alone option was found to represent a cost saving across sensitivity analyses. Conclusion The introduction of bevacizumab for the treatment of AMD is recommended for the Brazilian Public Health System.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/40369/1/license.txtd3e717dbb24bfc607ede047f44d29a0eMD51ORIGINALve_Flavia_Elias_etal.PDFve_Flavia_Elias_etal.PDFapplication/pdf347885https://www.arca.fiocruz.br/bitstream/icict/40369/2/ve_Flavia_Elias_etal.PDF232f9bcf477a157a625a44fdf2693d48MD52TEXTve_Flavia_Elias_etal.PDF.txtve_Flavia_Elias_etal.PDF.txtExtracted texttext/plain35686https://www.arca.fiocruz.br/bitstream/icict/40369/3/ve_Flavia_Elias_etal.PDF.txt6d1b7a6b2379381f7e8cc188080cd531MD53icict/403692020-03-19 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dc.title.pt_BR.fl_str_mv Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
title Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
spellingShingle Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
Elias, Flávia Tavares Silva
Macular Degeneration
Macular degeneration
Costs and cost analysis
Public health
Degeneração Macular
Custos e Análise de Custo
Saúde Pública
title_short Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
title_full Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
title_fullStr Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
title_full_unstemmed Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
title_sort Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system
author Elias, Flávia Tavares Silva
author_facet Elias, Flávia Tavares Silva
Silva, Everton Nunes da
Belfort, Rubens
Silva, Marcus Tolentino
Atallah, Álvaro Nagib
author_role author
author2 Silva, Everton Nunes da
Belfort, Rubens
Silva, Marcus Tolentino
Atallah, Álvaro Nagib
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Elias, Flávia Tavares Silva
Silva, Everton Nunes da
Belfort, Rubens
Silva, Marcus Tolentino
Atallah, Álvaro Nagib
dc.subject.mesh.pt_BR.fl_str_mv Macular Degeneration
topic Macular Degeneration
Macular degeneration
Costs and cost analysis
Public health
Degeneração Macular
Custos e Análise de Custo
Saúde Pública
dc.subject.en.pt_BR.fl_str_mv Macular degeneration
Costs and cost analysis
Public health
dc.subject.decs.pt_BR.fl_str_mv Degeneração Macular
Custos e Análise de Custo
Saúde Pública
description Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2020-03-18T12:49:58Z
dc.date.available.fl_str_mv 2020-03-18T12:49:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ELIAS, Flávia Tavares Silva et al. Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system. PLoS ONE, San Francisco, v. 10, n. 10, oct. 2015. 10 p.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40369
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.eissn.none.fl_str_mv 10.1371/journal.pone.0139556
identifier_str_mv ELIAS, Flávia Tavares Silva et al. Treatment options for age-related macular degeneration: a budget impact analysis from the perspective of the Brazilian public health system. PLoS ONE, San Francisco, v. 10, n. 10, oct. 2015. 10 p.
1932-6203
10.1371/journal.pone.0139556
url https://www.arca.fiocruz.br/handle/icict/40369
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv University of Miami School of Medicine. Bascom Palmer Eye Institute
publisher.none.fl_str_mv University of Miami School of Medicine. Bascom Palmer Eye Institute
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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