Dengue infection modulates locomotion and host seeking in Aedes aegypti

Detalhes bibliográficos
Autor(a) principal: Tallon, Anaïs K.
Data de Publicação: 2020
Outros Autores: Lorenzo, Marcelo Gustavo, Moreira, Luciano Andrade, Villegas, Luis Eduardo Martínez, Hill, Sharon Rose, Ignell, Rickard
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43900
Resumo: Disease Vector Group. Department of Plant Protection Biology.Swedish University of Agricultural Sciences. Alnarp, Sweden
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spelling Tallon, Anaïs K.Lorenzo, Marcelo GustavoMoreira, Luciano AndradeVillegas, Luis Eduardo MartínezHill, Sharon RoseIgnell, Rickard2020-10-09T13:42:43Z2020-10-09T13:42:43Z2020TALLON, Anais K. et al. Dengue infection modulates locomotion and host seeking in Aedes aegypti. PLoS Negl Trop Dis, v. 14, n. 9, e00085312020.1935-2735https://www.arca.fiocruz.br/handle/icict/4390010.1371/journal.pntd.0008531engPublic Library of ScienceDengueAedes aegyptiDengueAedes aegyptiDengue infection modulates locomotion and host seeking in Aedes aegyptiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDisease Vector Group. Department of Plant Protection Biology.Swedish University of Agricultural Sciences. Alnarp, SwedenVector Behaviour and Pathogen Interaction Group. Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, Minas Gerais, BrazilMosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor. Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, BrazilVector Behaviour and Pathogen Interaction Group. Instituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, Minas Gerais, BrazilDisease Vector Group. Department of Plant Protection Biology.Swedish University of Agricultural Sciences. Alnarp, SwedenDisease Vector Group. Department of Plant Protection Biology.Swedish University of Agricultural Sciences. Alnarp, SwedenPathogens may manipulate their human and mosquito hosts to enhance disease transmission. Dengue, caused by four viral serotypes, is the fastest-growing transmissible disease globally resulting in 50–100 million infections annually. Transmission of the disease relies on the interaction between humans and the vector Aedes aegypti and is largely dependent on the odor-mediated host seeking of female mosquitoes. In this study, we use activity monitors to demonstrate that dengue virus-1 affects the locomotion and odor-mediated behavior of Ae. aegypti, reflecting the progression of infection within the mosquito. Mosquitoes 4–6 days post-infection increase locomotion, but do not alter their odor-driven host-seeking response. In contrast, females 14–16 days post-infection are less active, yet more sensitive to human odors as assessed by behavioral and electrophysiological assays. Such an increase in physiological and behavioral sensitivity is reflected by the antennal-specific increase in abundance of neural signaling transcripts in 14 days post-infection females, as determined by transcriptome analysis. This suggests that the sensitivity of the mosquito peripheral olfactory system is altered by the dengue virus by enhancing the overall neural responsiveness of the antenna, rather than the selective regulation of chemosensory-related genes. Our study reveals that dengue virus-1 enhances vector-related behaviors in the early stages post-infection that aid in avoiding predation and increasing spatial exploration. On the other hand, at the later stages of infection, the virus enhances the host-seeking capacity of the vector, thereby increasing the risk of virus transmission. A potential mechanism is discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/43900/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDengue infection modulates locomotion and host seeking in Aedes aegypti.pdfDengue infection modulates locomotion and host seeking in Aedes aegypti.pdfapplication/pdf2167379https://www.arca.fiocruz.br/bitstream/icict/43900/2/Dengue%20infection%20modulates%20locomotion%20and%20host%20seeking%20in%20Aedes%20aegypti.pdf6d43fa1fe986f7ebf0d905ae34093979MD52TEXTDengue infection modulates locomotion and host seeking in Aedes aegypti.pdf.txtDengue infection modulates locomotion and host seeking in Aedes aegypti.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Dengue infection modulates locomotion and host seeking in Aedes aegypti
title Dengue infection modulates locomotion and host seeking in Aedes aegypti
spellingShingle Dengue infection modulates locomotion and host seeking in Aedes aegypti
Tallon, Anaïs K.
Dengue
Aedes aegypti
Dengue
Aedes aegypti
title_short Dengue infection modulates locomotion and host seeking in Aedes aegypti
title_full Dengue infection modulates locomotion and host seeking in Aedes aegypti
title_fullStr Dengue infection modulates locomotion and host seeking in Aedes aegypti
title_full_unstemmed Dengue infection modulates locomotion and host seeking in Aedes aegypti
title_sort Dengue infection modulates locomotion and host seeking in Aedes aegypti
author Tallon, Anaïs K.
author_facet Tallon, Anaïs K.
Lorenzo, Marcelo Gustavo
Moreira, Luciano Andrade
Villegas, Luis Eduardo Martínez
Hill, Sharon Rose
Ignell, Rickard
author_role author
author2 Lorenzo, Marcelo Gustavo
Moreira, Luciano Andrade
Villegas, Luis Eduardo Martínez
Hill, Sharon Rose
Ignell, Rickard
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Tallon, Anaïs K.
Lorenzo, Marcelo Gustavo
Moreira, Luciano Andrade
Villegas, Luis Eduardo Martínez
Hill, Sharon Rose
Ignell, Rickard
dc.subject.other.pt_BR.fl_str_mv Dengue
Aedes aegypti
topic Dengue
Aedes aegypti
Dengue
Aedes aegypti
dc.subject.en.pt_BR.fl_str_mv Dengue
Aedes aegypti
description Disease Vector Group. Department of Plant Protection Biology.Swedish University of Agricultural Sciences. Alnarp, Sweden
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-09T13:42:43Z
dc.date.available.fl_str_mv 2020-10-09T13:42:43Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TALLON, Anais K. et al. Dengue infection modulates locomotion and host seeking in Aedes aegypti. PLoS Negl Trop Dis, v. 14, n. 9, e00085312020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43900
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0008531
identifier_str_mv TALLON, Anais K. et al. Dengue infection modulates locomotion and host seeking in Aedes aegypti. PLoS Negl Trop Dis, v. 14, n. 9, e00085312020.
1935-2735
10.1371/journal.pntd.0008531
url https://www.arca.fiocruz.br/handle/icict/43900
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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