Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/54629 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Souza, Thiara Manuele Alves deLima, Raquel Curtinhas deSolórzano, Victor Edgar FiestasDamasco, Paulo VieiraSouza, Luiz José deSanchez-Arcila, Juan CamiloGuimarães, Gabriel Macedo CostaPaiva, Iury AmâncioLima, Monique da Rocha QueirozBruycker-Nogueira, Fernanda deTomé, Larissa Cristina TeixeiraCoelho, Mariana Rosa InácioSilva, Sandro Patroca daPinto, Luzia Maria de OliveiraAzeredo, Elzinandes Leal deSantos, Flavia Barreto dos2022-08-12T20:11:41Z2022-08-12T20:11:41Z2022SOUZA, Thiara Manuele Alves de et al. Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil. Pathogens, v. 11, n. 245, p. 1-16, Feb. 2022.2076-0817https://www.arca.fiocruz.br/handle/icict/5462910.3390/pathogens11020245engMDPIArbovírusChikungunyaEpidemia triplaDiagnóstico laboratorial diferencialFilogeniaGenótipo ECSAArbovirusesChikungunyaTriple epidemicDifferential laboratorial diagnosisPhylogenyECSA genotypeWas It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Rio-Laranjeiras Hospital. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Graffrée Guinle. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.Plantadores de Cana Hospital. Campos dos Goytacazes, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.The co-circulation of chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV) in Rio de Janeiro (RJ), Brazil, caused a challenging triple epidemic, as they share similar clinical signs and symptoms and geographical distribution. Here, we aimed to investigate the clinical and laboratorial aspects of chikungunya suspected cases assisted in RJ during the 2018 outbreak, focusing on the differential diagnosis with dengue and zika. All suspected cases were submitted to molecular and/or serological differential diagnostic approaches to arboviruses. A total of 242 cases suspected of arbovirus infection were investigated and 73.6% (178/242) were molecular and/or serologically confirmed as chikungunya. In RT-qPCR confirmed cases, cycle threshold (Ct) values ranged from 15.46 to 35.13, with acute cases presenting lower values. Chikungunya cases were mainly in females (64%) and the most frequently affected age group was adults between 46 to 59 years old (27%). Polyarthralgia affected 89% of patients, especially in hands and feet. No dengue virus (DENV) and Zika virus (ZIKV) infections were confirmed by molecular diagnosis, but 9.5% (23/242) had serological evidence of DENV exposure by the detection of specific anti-DENV IgM or NS1, and 42.7% (76/178) of chikungunya positive cases also presented recent DENV exposure reflected by a positive anti-DENV IgM or NS1 result. A significantly higher frequency of arthritis (p = 0.023) and limb edema (p < 0.001) was found on patients with CHIKV monoinfection compared to dengue patients and patients exposed to both viruses. Lastly, phylogenetic analysis showed that the chikungunya cases were caused by the ECSA genotype. Despite the triple arboviruses’ epidemic in the state of RJ, most patients with fever and arthralgia investigated here were diagnosed as chikungunya cases, and the incidence of CHIKV/DENV co-detection was higher than that reported in other studies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54629/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFlaviaBSantos_LarissaTome_etal_IOC_2022.pdfFlaviaBSantos_LarissaTome_etal_IOC_2022.pdfapplication/pdf1877239https://www.arca.fiocruz.br/bitstream/icict/54629/2/FlaviaBSantos_LarissaTome_etal_IOC_2022.pdf7f6b6b42cb3d1ec30952fcae66e01988MD52icict/546292022-08-12 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Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil |
| title |
Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil |
| spellingShingle |
Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil Souza, Thiara Manuele Alves de Arbovírus Chikungunya Epidemia tripla Diagnóstico laboratorial diferencial Filogenia Genótipo ECSA Arboviruses Chikungunya Triple epidemic Differential laboratorial diagnosis Phylogeny ECSA genotype |
| title_short |
Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil |
| title_full |
Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil |
| title_fullStr |
Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil |
| title_full_unstemmed |
Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil |
| title_sort |
Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil |
| author |
Souza, Thiara Manuele Alves de |
| author_facet |
Souza, Thiara Manuele Alves de Lima, Raquel Curtinhas de Solórzano, Victor Edgar Fiestas Damasco, Paulo Vieira Souza, Luiz José de Sanchez-Arcila, Juan Camilo Guimarães, Gabriel Macedo Costa Paiva, Iury Amâncio Lima, Monique da Rocha Queiroz Bruycker-Nogueira, Fernanda de Tomé, Larissa Cristina Teixeira Coelho, Mariana Rosa Inácio Silva, Sandro Patroca da Pinto, Luzia Maria de Oliveira Azeredo, Elzinandes Leal de Santos, Flavia Barreto dos |
| author_role |
author |
| author2 |
Lima, Raquel Curtinhas de Solórzano, Victor Edgar Fiestas Damasco, Paulo Vieira Souza, Luiz José de Sanchez-Arcila, Juan Camilo Guimarães, Gabriel Macedo Costa Paiva, Iury Amâncio Lima, Monique da Rocha Queiroz Bruycker-Nogueira, Fernanda de Tomé, Larissa Cristina Teixeira Coelho, Mariana Rosa Inácio Silva, Sandro Patroca da Pinto, Luzia Maria de Oliveira Azeredo, Elzinandes Leal de Santos, Flavia Barreto dos |
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author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Thiara Manuele Alves de Lima, Raquel Curtinhas de Solórzano, Victor Edgar Fiestas Damasco, Paulo Vieira Souza, Luiz José de Sanchez-Arcila, Juan Camilo Guimarães, Gabriel Macedo Costa Paiva, Iury Amâncio Lima, Monique da Rocha Queiroz Bruycker-Nogueira, Fernanda de Tomé, Larissa Cristina Teixeira Coelho, Mariana Rosa Inácio Silva, Sandro Patroca da Pinto, Luzia Maria de Oliveira Azeredo, Elzinandes Leal de Santos, Flavia Barreto dos |
| dc.subject.other.pt_BR.fl_str_mv |
Arbovírus Chikungunya Epidemia tripla Diagnóstico laboratorial diferencial Filogenia Genótipo ECSA |
| topic |
Arbovírus Chikungunya Epidemia tripla Diagnóstico laboratorial diferencial Filogenia Genótipo ECSA Arboviruses Chikungunya Triple epidemic Differential laboratorial diagnosis Phylogeny ECSA genotype |
| dc.subject.en.pt_BR.fl_str_mv |
Arboviruses Chikungunya Triple epidemic Differential laboratorial diagnosis Phylogeny ECSA genotype |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022-08-12T20:11:41Z |
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2022-08-12T20:11:41Z |
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2022 |
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SOUZA, Thiara Manuele Alves de et al. Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil. Pathogens, v. 11, n. 245, p. 1-16, Feb. 2022. |
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https://www.arca.fiocruz.br/handle/icict/54629 |
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2076-0817 |
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10.3390/pathogens11020245 |
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SOUZA, Thiara Manuele Alves de et al. Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil. Pathogens, v. 11, n. 245, p. 1-16, Feb. 2022. 2076-0817 10.3390/pathogens11020245 |
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