Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Neira-Goulart, Milena
Data de Publicação: 2023
Outros Autores: Sá, Nathalia Beatriz Ramos de, Ribeiro-Alves, Marcelo, Perazzo, Hugo, Geraldo, Kim Mattos, Ribeiro, Maria Pia Diniz, Cardoso, Sandra Wagner, Grinsztejn, Beatriz, Veloso, Valdiléa G., Gomes, Larissa Rodrigues, Cazote, Andressa da Silva, Almeida, Dalziza Victalina de, Giacoia-Gripp, Carmem Beatriz Wagner, Côrtes, Fernanda Heloise, Morgado, Mariza Gonçalves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.gene.2023.147325
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58991
Resumo: Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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spelling Neira-Goulart, MilenaSá, Nathalia Beatriz Ramos deRibeiro-Alves, MarceloPerazzo, HugoGeraldo, Kim MattosRibeiro, Maria Pia DinizCardoso, Sandra WagnerGrinsztejn, BeatrizVeloso, Valdiléa G.Gomes, Larissa RodriguesCazote, Andressa da SilvaAlmeida, Dalziza Victalina deGiacoia-Gripp, Carmem Beatriz WagnerCôrtes, Fernanda HeloiseMorgado, Mariza Gonçalves2023-06-13T00:20:04Z2023-06-13T00:20:04Z2023NEIRA-GOULART, Milena et al. Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil. Gene, p. 1-11, May 2023.0378-1119https://www.arca.fiocruz.br/handle/icict/5899110.1016/j.gene.2023.1473251879-0038Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.The study protocol was approved by the Ethics Committee of the National Institute of Infectology Evandro Chagas (INI)/Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil, under approval number CAAE: 32449420.4.1001.5262. All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national).The study was supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ (Grant number SEI-260003/002689/2020; SEI- 260003/013002/2021 and SEI260003/019710/2022) and INOVA FIOCRUZ/Fundação Oswaldo Cruz (Grant number 48401996705881). Hugo Perazzo is recipient of FAPERJ (E-26/201.351/2021), Mariza Gonçalves Morgado is recipient of CNPQ (314064/2018-4) and FAPERJ (E-26/201.177/2021), and Beatriz Grinsztejn is recipient of CNPQ (305789/2019-8) and FAPERJ (E-26/202.915/2018). The funding agencies played no role in the design of the study, data collection, analysis, or interpretation, nor in writing the manuscript.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Center of Technological Development in Health. National Institute of Science and Technological for Innovation on Neglected Population Diseases. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil.COVID-19 has a broad spectrum of clinical manifestations. We assessed the impact of single nucleotide polymorphisms (SNPs) of inflammasome genesas risk factors for progression toCOVID-19 critical outcomes, such as mechanical ventilation support (MVS) or death.The study included 451 hospitalized individuals followed up at the INI/FIOCRUZ, Rio de Janeiro, Brazil, from 06/2020 to 03/2021. SNPs genotyping was determined by Real-Time PCR. We analyzed risk factors for progression to MVS (n = 174[38.6 %]) or death (n = 175[38.8 %])as a result of COVID-19 by Cox proportional hazardmodels.Slower progression toMVSwas associated with allele G (aHR = 0.66;P = 0.005) or the genotype G/G (aHR = 0.391;P = 0.006) in the NLRP3 rs10754558 or the allele G (aHR = 0.309;P = 0.004) in the IL1βrs1143634, while C allele in the NLRP3 rs4612666 (aHR = 2.342;P = 0.006) or in the rs10754558 (aHR = 2.957;P = 0.005) were associated with faster progression to death. Slower progression to death was associated to allele G (aHR = 0.563;P = 0.006) or the genotype A/G (aHR = 0.537;P = 0.005) in the CARD8 rs6509365; the genotype A/C in the IFI16 rs1101996 (aHR = 0.569;P = 0.011); the genotype T/T (aHR = 0.394;P = 0.004) or allele T (aHR = 0.68;P = 0.006) in the NLRP3 rs4612666, and the genotype G/G (aHR = 0.326;P = 0.005) or allele G (aHR = 0,68;P = 0.014) in the NLRP3 rs10754558. Our results suggest that inflammasome genetic variations might influence the critical clinical course of COVID-19.engElsevierInflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19Inflammasome single nucleotide polymorphisms (SNPs)Risk factorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Milena_Neira-Goulart_etal_INI_IOC_2023.pdfve_Milena_Neira-Goulart_etal_INI_IOC_2023.pdfapplication/pdf601900https://www.arca.fiocruz.br/bitstream/icict/58991/2/ve_Milena_Neira-Goulart_etal_INI_IOC_2023.pdf6bc106cf9444770daf96b8c8782f68e3MD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
title Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
spellingShingle Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
Neira-Goulart, Milena
COVID-19
Inflammasome single nucleotide polymorphisms (SNPs)
Risk factors
title_short Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
title_full Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
title_fullStr Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
title_full_unstemmed Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
title_sort Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil
author Neira-Goulart, Milena
author_facet Neira-Goulart, Milena
Sá, Nathalia Beatriz Ramos de
Ribeiro-Alves, Marcelo
Perazzo, Hugo
Geraldo, Kim Mattos
Ribeiro, Maria Pia Diniz
Cardoso, Sandra Wagner
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Gomes, Larissa Rodrigues
Cazote, Andressa da Silva
Almeida, Dalziza Victalina de
Giacoia-Gripp, Carmem Beatriz Wagner
Côrtes, Fernanda Heloise
Morgado, Mariza Gonçalves
author_role author
author2 Sá, Nathalia Beatriz Ramos de
Ribeiro-Alves, Marcelo
Perazzo, Hugo
Geraldo, Kim Mattos
Ribeiro, Maria Pia Diniz
Cardoso, Sandra Wagner
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Gomes, Larissa Rodrigues
Cazote, Andressa da Silva
Almeida, Dalziza Victalina de
Giacoia-Gripp, Carmem Beatriz Wagner
Côrtes, Fernanda Heloise
Morgado, Mariza Gonçalves
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neira-Goulart, Milena
Sá, Nathalia Beatriz Ramos de
Ribeiro-Alves, Marcelo
Perazzo, Hugo
Geraldo, Kim Mattos
Ribeiro, Maria Pia Diniz
Cardoso, Sandra Wagner
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Gomes, Larissa Rodrigues
Cazote, Andressa da Silva
Almeida, Dalziza Victalina de
Giacoia-Gripp, Carmem Beatriz Wagner
Côrtes, Fernanda Heloise
Morgado, Mariza Gonçalves
dc.subject.en.en_US.fl_str_mv COVID-19
Inflammasome single nucleotide polymorphisms (SNPs)
Risk factors
topic COVID-19
Inflammasome single nucleotide polymorphisms (SNPs)
Risk factors
description Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-13T00:20:04Z
dc.date.available.fl_str_mv 2023-06-13T00:20:04Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NEIRA-GOULART, Milena et al. Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil. Gene, p. 1-11, May 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58991
dc.identifier.issn.en_US.fl_str_mv 0378-1119
dc.identifier.doi.none.fl_str_mv 10.1016/j.gene.2023.147325
dc.identifier.eissn.none.fl_str_mv 1879-0038
identifier_str_mv NEIRA-GOULART, Milena et al. Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil. Gene, p. 1-11, May 2023.
0378-1119
10.1016/j.gene.2023.147325
1879-0038
url https://www.arca.fiocruz.br/handle/icict/58991
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58991/2/ve_Milena_Neira-Goulart_etal_INI_IOC_2023.pdf
https://www.arca.fiocruz.br/bitstream/icict/58991/1/license.txt
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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