Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels

Detalhes bibliográficos
Autor(a) principal: Magalhães, Elizabeth Soares da Silva
Data de Publicação: 2020
Outros Autores: Méio, Maria Dalva Barbosa Baker, Peixoto-Filho, Fernando Maia, Gonzalez, Sayonara, Costa, Ana Carolina Carioca da, Moreira, Maria Elisabeth Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46917
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
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spelling Magalhães, Elizabeth Soares da SilvaMéio, Maria Dalva Barbosa BakerPeixoto-Filho, Fernando MaiaGonzalez, SayonaraCosta, Ana Carolina Carioca daMoreira, Maria Elisabeth Lopes2021-04-26T19:54:16Z2021-04-26T19:54:16Z2020MAGALHÃES, Elizabeth Soares da Silva et al. Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels. European Journal of Pediatrics, v. 179, n. 8, p. 1239-1246, Aug. 2020.0340-6199https://www.arca.fiocruz.br/handle/icict/4691710.1007/s00431-020-03586-8engSpringer [Commercial Publisher], Belgian Pediatric Society [Associate Organisation], Swiss Pediatric Society [Associate Organisation], Belgian Pediatric Association [Associate Organisation]Adipokines / bloodAdolescentAdultBiomarkers / bloodCase-Control StudiesFemaleFetal Blood / metabolismGhrelin / bloodHumansHypertension, Pregnancy-Induced / bloodInfant, NewbornInfant, Small for Gestational AgeLinear ModelsMalePregnancyYoung AdultPremature Birth / bloodPrematureBirth / etiologyProspective StudiesRisk FactorsAdiponectinGhrelinIntrauterine growth restrictionLeptinPregnancy-induced hypertensionPretermPregnancy-induced hypertension, preterm birth, and cord blood adipokine levelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Department of Obstetrics. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Department of Medical Genetics. Laboratory of Genomic Medicine. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Maternal hypertension may alter physiological parameters, dysregulating the release of hormones such as adipokines, thus influencing the fetal growth course. This study investigated whether hypertensive disorders of pregnancy alter cord blood adipokine levels and correlate these with anthropometric parameters in preterm infants. This is a prospective cohort study with pregnant women < 37-week gestation with and without hypertension and their offspring. Cord blood leptin, adiponectin, and ghrelin were analyzed by LUMINEX®. These adipokines were compared between the groups exposed or not to gestational hypertension using non-parametric statistical tests. The hypertensive pregnancies had significantly higher cord blood leptin (1.00 (IQR 0.67-1.20 ng/mL)) and adiponectin (18.52 (IQR 17.52-25.13 μg/mL)) levels than those without hypertension (0.07 (IQR 0.06-0.08 ng/mL) and 8.13 (IQR 6.50-8.68 μg/mL), respectively, p < 0.0001). The adipokine levels were higher in AGA and SGA infants in the exposed group for both moderate and late preterm. SGA had significantly higher ghrelin levels than the AGA infants. Ghrelin levels were negatively correlated with birth weight (r = - 0.613, p < 0.001), birth length (r = - 0.510, p < 0.001), head circumference (- 0.346, p < 0.002), and gestational age (r = - 0.612, p < 0.001).Conclusions: Our findings demonstrate an increase in adipokine levels in the cord blood of preterm newborn infants exposed to maternal hypertension. What is Known: • Clinical evidence suggests that concentration of the serum adipokines may be affected by risk of hypertension in both adults and pregnant women. • Maternal profile as hypertension alters intrauterine environment and could affect the function of fetal metabolism, impairing fetal growth. What is New: • Gestational hypertension modifies the adipokine profile, with higher rates already present at birth in cord blood samples. • Within the hypertensive group and stratifying for gestation age, ghrelin concentrations were higher in SGA newborns, both in the moderate and late preterm, compared with AGA newborns.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://www.arca.fiocruz.br/bitstream/icict/46917/1/license.txt0ab46789d568c4ba27c7b5d29a9fe9c4MD51ORIGINALMagalhães_Elizabeth_etal_IFF_2020.pdfMagalhães_Elizabeth_etal_IFF_2020.pdfapplication/pdf469654https://www.arca.fiocruz.br/bitstream/icict/46917/2/Magalh%c3%a3es_Elizabeth_etal_IFF_2020.pdfb0fc160649bdd54243ac2f96186d271aMD52TEXTMagalhães_Elizabeth_etal_IFF_2020.pdf.txtMagalhães_Elizabeth_etal_IFF_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
title Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
spellingShingle Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
Magalhães, Elizabeth Soares da Silva
Adipokines / blood
Adolescent
Adult
Biomarkers / blood
Case-Control Studies
Female
Fetal Blood / metabolism
Ghrelin / blood
Humans
Hypertension, Pregnancy-Induced / blood
Infant, Newborn
Infant, Small for Gestational Age
Linear Models
Male
Pregnancy
Young Adult
Premature Birth / blood
PrematureBirth / etiology
Prospective Studies
Risk Factors
Adiponectin
Ghrelin
Intrauterine growth restriction
Leptin
Pregnancy-induced hypertension
Preterm
title_short Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
title_full Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
title_fullStr Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
title_full_unstemmed Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
title_sort Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels
author Magalhães, Elizabeth Soares da Silva
author_facet Magalhães, Elizabeth Soares da Silva
Méio, Maria Dalva Barbosa Baker
Peixoto-Filho, Fernando Maia
Gonzalez, Sayonara
Costa, Ana Carolina Carioca da
Moreira, Maria Elisabeth Lopes
author_role author
author2 Méio, Maria Dalva Barbosa Baker
Peixoto-Filho, Fernando Maia
Gonzalez, Sayonara
Costa, Ana Carolina Carioca da
Moreira, Maria Elisabeth Lopes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Magalhães, Elizabeth Soares da Silva
Méio, Maria Dalva Barbosa Baker
Peixoto-Filho, Fernando Maia
Gonzalez, Sayonara
Costa, Ana Carolina Carioca da
Moreira, Maria Elisabeth Lopes
dc.subject.mesh.pt_BR.fl_str_mv Adipokines / blood
Adolescent
Adult
Biomarkers / blood
Case-Control Studies
Female
Fetal Blood / metabolism
Ghrelin / blood
Humans
Hypertension, Pregnancy-Induced / blood
Infant, Newborn
Infant, Small for Gestational Age
Linear Models
Male
Pregnancy
Young Adult
Premature Birth / blood
PrematureBirth / etiology
Prospective Studies
Risk Factors
topic Adipokines / blood
Adolescent
Adult
Biomarkers / blood
Case-Control Studies
Female
Fetal Blood / metabolism
Ghrelin / blood
Humans
Hypertension, Pregnancy-Induced / blood
Infant, Newborn
Infant, Small for Gestational Age
Linear Models
Male
Pregnancy
Young Adult
Premature Birth / blood
PrematureBirth / etiology
Prospective Studies
Risk Factors
Adiponectin
Ghrelin
Intrauterine growth restriction
Leptin
Pregnancy-induced hypertension
Preterm
dc.subject.en.pt_BR.fl_str_mv Adiponectin
Ghrelin
Intrauterine growth restriction
Leptin
Pregnancy-induced hypertension
Preterm
description Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-04-26T19:54:16Z
dc.date.available.fl_str_mv 2021-04-26T19:54:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAGALHÃES, Elizabeth Soares da Silva et al. Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels. European Journal of Pediatrics, v. 179, n. 8, p. 1239-1246, Aug. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46917
dc.identifier.issn.pt_BR.fl_str_mv 0340-6199
dc.identifier.doi.none.fl_str_mv 10.1007/s00431-020-03586-8
identifier_str_mv MAGALHÃES, Elizabeth Soares da Silva et al. Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels. European Journal of Pediatrics, v. 179, n. 8, p. 1239-1246, Aug. 2020.
0340-6199
10.1007/s00431-020-03586-8
url https://www.arca.fiocruz.br/handle/icict/46917
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer [Commercial Publisher], Belgian Pediatric Society [Associate Organisation], Swiss Pediatric Society [Associate Organisation], Belgian Pediatric Association [Associate Organisation]
publisher.none.fl_str_mv Springer [Commercial Publisher], Belgian Pediatric Society [Associate Organisation], Swiss Pediatric Society [Associate Organisation], Belgian Pediatric Association [Associate Organisation]
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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