CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13052 |
Resumo: | Ministry of Health. National Institute of Health. Maputo, Mozambique. |
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Chissumba, Raquel MataveleBarbosa, Suse Dayse SilvaAugusto, ÂngeloMauela, CremildoMabunda, NédioGudo Jr, Eduardo SarnoBhatt, NileshJani, IleshSavino, Wilson2016-03-08T14:26:31Z2016-03-08T14:26:31Z2015CHISSUMBA, Raquel Matavele; et al. CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor. BMC Immunology, v.16:52, 9p, 2015.1471-2172https://www.arca.fiocruz.br/handle/icict/1305210.1186/s12865-015-0116-xengBioMed CentralInfecções por HTLVNeuropatiasInfecções por HIVHIV/HTLV Co-infected patientsNeuropathyFoxp3 transcription factorCD4+ CD25High Treg cellsAlpha4 integrinCD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistry of Health. National Institute of Health. Maputo, Mozambique.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Background: Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-infection are more prone to develop neurological complications. The aim of this study was to characterize phenotypically Treg cells in HIV-1/HTLV-1 co-infected Mozambican individuals presenting neurological symptoms. Methods: A cross-sectional study was conducted among HIV-infected individuals presentingneurological symptoms, with and without HTLV co-infection, and blood donors. Peripheral bloodmononuclear cells were stained with monoclonal antibodies conjugated with fluorochromes to quantifyTregs and activated T cells by four colors flow cytometry. Results: Higher Treg cell frequency (10.6 %) was noted in HIV-1/HTLV-1 co-infected group with neurological symptoms when compared to HIV-1 mono-infected group with neurological symptoms (0.38 %, p = 0.003) and control group (0.9 %, p = 0.0105). An inverse correlation between Foxp3 and CD49d expression was observed in all study groups (rh = −0.71, p = 0.001). In addition, increased levels of Treg cells in co-infected patients were strongly associated with total activated CD4 T cells (rh = 0.8, p = 0.01). Conclusion: Treg cells in co-infected patients present phenotypic alterations and might have dysfunction marked by low expression of Foxp3 and increased expression of molecules not frequently seen on Treg cells, such as CD49d. These alterations may be related to (1) changes in Treg cell trafficking and migration, possibly making those cells susceptible to HIV infection, and (2) inability to control the activation and proliferation of effector T lymphocytes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13052/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALwilson_savino_etal_IOC_2015.pdfwilson_savino_etal_IOC_2015.pdfapplication/pdf718610https://www.arca.fiocruz.br/bitstream/icict/13052/2/wilson_savino_etal_IOC_2015.pdfe5567ab75523b3c84f56fec19abe6671MD52TEXTwilson_savino_etal_IOC_2015.pdf.txtwilson_savino_etal_IOC_2015.pdf.txtExtracted texttext/plain36808https://www.arca.fiocruz.br/bitstream/icict/13052/3/wilson_savino_etal_IOC_2015.pdf.txt5ebfc0317527fcaf680911f4d2b23860MD53icict/130522018-04-02 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dc.title.pt_BR.fl_str_mv |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor |
title |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor |
spellingShingle |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor Chissumba, Raquel Matavele Infecções por HTLV Neuropatias Infecções por HIV HIV/HTLV Co-infected patients Neuropathy Foxp3 transcription factor CD4+ CD25High Treg cells Alpha4 integrin |
title_short |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor |
title_full |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor |
title_fullStr |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor |
title_full_unstemmed |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor |
title_sort |
CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor |
author |
Chissumba, Raquel Matavele |
author_facet |
Chissumba, Raquel Matavele Barbosa, Suse Dayse Silva Augusto, Ângelo Mauela, Cremildo Mabunda, Nédio Gudo Jr, Eduardo Sarno Bhatt, Nilesh Jani, Ilesh Savino, Wilson |
author_role |
author |
author2 |
Barbosa, Suse Dayse Silva Augusto, Ângelo Mauela, Cremildo Mabunda, Nédio Gudo Jr, Eduardo Sarno Bhatt, Nilesh Jani, Ilesh Savino, Wilson |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Chissumba, Raquel Matavele Barbosa, Suse Dayse Silva Augusto, Ângelo Mauela, Cremildo Mabunda, Nédio Gudo Jr, Eduardo Sarno Bhatt, Nilesh Jani, Ilesh Savino, Wilson |
dc.subject.other.pt_BR.fl_str_mv |
Infecções por HTLV Neuropatias Infecções por HIV |
topic |
Infecções por HTLV Neuropatias Infecções por HIV HIV/HTLV Co-infected patients Neuropathy Foxp3 transcription factor CD4+ CD25High Treg cells Alpha4 integrin |
dc.subject.en.pt_BR.fl_str_mv |
HIV/HTLV Co-infected patients Neuropathy Foxp3 transcription factor CD4+ CD25High Treg cells Alpha4 integrin |
description |
Ministry of Health. National Institute of Health. Maputo, Mozambique. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-03-08T14:26:31Z |
dc.date.available.fl_str_mv |
2016-03-08T14:26:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CHISSUMBA, Raquel Matavele; et al. CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor. BMC Immunology, v.16:52, 9p, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/13052 |
dc.identifier.issn.none.fl_str_mv |
1471-2172 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12865-015-0116-x |
identifier_str_mv |
CHISSUMBA, Raquel Matavele; et al. CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor. BMC Immunology, v.16:52, 9p, 2015. 1471-2172 10.1186/s12865-015-0116-x |
url |
https://www.arca.fiocruz.br/handle/icict/13052 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BioMed Central |
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BioMed Central |
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Repositório Institucional da FIOCRUZ (ARCA) |
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