The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury

Detalhes bibliográficos
Autor(a) principal: Carvalho, Caio Cesar
Data de Publicação: 2016
Outros Autores: Melo, Mayla Gabryele Miranda de, Santana, Leonardo, Andrade, Bruno de Bezerril, Mesquita, Eliene, Miranda, Pryscila, Kritski, Afrânio Lineu, Oliveira, Martha Marques, Silva, Elisangela C.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18033
Resumo: CNPq, FAPERJ, CAPES
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spelling Carvalho, Caio CesarMelo, Mayla Gabryele Miranda deSantana, LeonardoAndrade, Bruno de BezerrilMesquita, ElieneMiranda, PryscilaKritski, Afrânio LineuOliveira, Martha MarquesSilva, Elisangela C.2017-03-14T13:47:11Z2017-03-14T13:47:11Z2016CARVALHO, C. C. et al. The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 52., 2016, Alagoas. Anais eletrônicos... Alagoas: Sociedade Brasileira de Medicina Tropical, 2016. p. 10831.https://www.arca.fiocruz.br/handle/icict/18033CNPq, FAPERJ, CAPESFederal University Rio de Janeiro. University Hospital Clementino Fraga Filho. Research Center in Infectious and Parasitic Diseases, Medicine School. Molecular Micobacteriology Laboratory. Rio de Janeiro, RJ, Brazil.Federal University Rio de Janeiro. University Hospital Clementino Fraga Filho. Research Center in Infectious and Parasitic Diseases, Medicine School. Molecular Micobacteriology Laboratory. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil.Ary Parreira Institute. State Secretary of Health. Rio de Janeiro, RJ, Brazil.Federal University Rio de Janeiro. University Hospital Clementino Fraga Filho. Research Center in Infectious and Parasitic Diseases, Medicine School. Molecular Micobacteriology Laboratory. Rio de Janeiro, RJ, Brazil.Federal University Rio de Janeiro. University Hospital Clementino Fraga Filho. Research Center in Infectious and Parasitic Diseases, Medicine School. Molecular Micobacteriology Laboratory. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Tuberculosis Academic Program, School of Medicine. Rio de Janeiro, RJ, Brazil.Federal University Rio de Janeiro. University Hospital Clementino Fraga Filho. Research Center in Infectious and Parasitic Diseases, Medicine School. Molecular Micobacteriology Laboratory. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Development Center for Technology on Health. Rio de Janeiro, RJ, Brazil.Federal University Rio de Janeiro. University Hospital Clementino Fraga Filho. Research Center in Infectious and Parasitic Diseases, Medicine School. Molecular Micobacteriology Laboratory. Rio de Janeiro, RJ, Brazil / State University of North Fluminense Darcy Ribeiro. Center of Bioscience and Biotechnology. Recognize the Biology Laboratory. Rio de Janeiro, RJ, Brazil.Matrix metalloproteinases (MMPs) is a group of regulator proteins involved with tissue remodeling in infectious diseases. Human tuberculosis (TB) is characterized by extensive lung destruction driven by host MMPs, particularly collagenases such as matrix MMP-1 and 8. Scarce data are available on the evaluation of MMPs serum levels in TB pathogenesis. In the present study, we prospectively depict the immune profile, microbial clearance and evolution of radiographic lesions in pulmonary tuberculosis (PTB) patient cohort before and 60 days after anti-tuberculous treatment (ATT) initiation. Circulating levels of MMP-1 and MMP-8 were measured by Luminex in cryopreserved serum samples obtained of 82 PTB patients. The analysis presented correlations of MMP-1 and -8, with mycobacterial loads and, the response at radiographic chest image, We did not find association of MMP-1 and MMP-8 with mycobacterial loads before and 60 days after ATT, but higher MMP-1 or lower MMP-8 levels were associated with no radiological improvement. In conclusion, our data showed that MMPs -1/-8 serum levels may be useful to predict the pulmonary involvement during TB treatment. The inverse relation of MMP-1 and MMP-8 and no radiological pulmonary TB suggests the presence of auto-regulatory aspects that warrants further investigation.engSociedade Brasileira de Medicina TropicalMatriz metaloproteinasesTuberculoseLesão pulmonarMatrix metalloproteinasesTuberculosisTissue remodelingThe balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18033/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho CC 10831-The-balance-between-MMP-1-and-MMP-8-in-tuberculosis-may-be-induce-pulmonary-injury..pdfCarvalho CC 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dc.title.pt_BR.fl_str_mv The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
title The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
spellingShingle The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
Carvalho, Caio Cesar
Matriz metaloproteinases
Tuberculose
Lesão pulmonar
Matrix metalloproteinases
Tuberculosis
Tissue remodeling
title_short The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
title_full The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
title_fullStr The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
title_full_unstemmed The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
title_sort The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury
author Carvalho, Caio Cesar
author_facet Carvalho, Caio Cesar
Melo, Mayla Gabryele Miranda de
Santana, Leonardo
Andrade, Bruno de Bezerril
Mesquita, Eliene
Miranda, Pryscila
Kritski, Afrânio Lineu
Oliveira, Martha Marques
Silva, Elisangela C.
author_role author
author2 Melo, Mayla Gabryele Miranda de
Santana, Leonardo
Andrade, Bruno de Bezerril
Mesquita, Eliene
Miranda, Pryscila
Kritski, Afrânio Lineu
Oliveira, Martha Marques
Silva, Elisangela C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Caio Cesar
Melo, Mayla Gabryele Miranda de
Santana, Leonardo
Andrade, Bruno de Bezerril
Mesquita, Eliene
Miranda, Pryscila
Kritski, Afrânio Lineu
Oliveira, Martha Marques
Silva, Elisangela C.
dc.subject.other.pt_BR.fl_str_mv Matriz metaloproteinases
Tuberculose
Lesão pulmonar
topic Matriz metaloproteinases
Tuberculose
Lesão pulmonar
Matrix metalloproteinases
Tuberculosis
Tissue remodeling
dc.subject.en.pt_BR.fl_str_mv Matrix metalloproteinases
Tuberculosis
Tissue remodeling
description CNPq, FAPERJ, CAPES
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-14T13:47:11Z
dc.date.available.fl_str_mv 2017-03-14T13:47:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv CARVALHO, C. C. et al. The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 52., 2016, Alagoas. Anais eletrônicos... Alagoas: Sociedade Brasileira de Medicina Tropical, 2016. p. 10831.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18033
identifier_str_mv CARVALHO, C. C. et al. The balance between MMP-1 and MMP-8 in tuberculosis may be induce pulmonary injury. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 52., 2016, Alagoas. Anais eletrônicos... Alagoas: Sociedade Brasileira de Medicina Tropical, 2016. p. 10831.
url https://www.arca.fiocruz.br/handle/icict/18033
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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