Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides

Detalhes bibliográficos
Autor(a) principal: Maciel, Ceres
Data de Publicação: 2008
Outros Autores: Oliveira Junior, Vani Xavier de, Fazio, Marcos Antonio, Pimenta, Rafael Nacif, Miranda, Antonio, Pimenta, Paulo Filemon Paolucci, Capurro, Margareth Lara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6661
Resumo: FAPESP, CNPq
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spelling Maciel, CeresOliveira Junior, Vani Xavier deFazio, Marcos AntonioPimenta, Rafael NacifMiranda, AntonioPimenta, Paulo Filemon PaolucciCapurro, Margareth Lara2013-07-09T17:38:14Z2013-07-09T17:38:14Z2008MACIEL, Ceres et al. Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides. PLoS ONE, v. 3, n. 9, p. 1-8, 2008.https://www.arca.fiocruz.br/handle/icict/666110.1371/journal.pone.0003296FAPESP, CNPqUniversity of São Paulo. Institute of Biomedical Sciences. Department of Parasitology. São Paulo, SP, Brazil.Federal University of ABC. Natural and Human Science Center. Santo Andre, SP Brazil.Federal University of São Paulo. Department of Biophysics. São Paulo, SP, Brazil.Oswaldo Cruz Foundation. Rene Rachou Institute of Research. Laboratory of Medical Entomology. Belo Horizonte, MG, Brazil.Federal University of São Paulo. Department of Biophysics. São Paulo, SP, Brazil.Oswaldo Cruz Foundation. Rene Rachou Institute of Research. Laboratory of Medical Entomology. Belo Horizonte, MG, Brazil.University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology. São Paulo, SP, Brazil.Plasmodiumspecies are the causative agents of malaria, the most devastating insect-borne parasite of human populations. Finding and developing new drugs for malaria treatment and prevention is the goal of much research. Angiotensins I and II (ang I and ang II) and six synthetic related peptides designated Vaniceres 1-6 (VC1-VC6) were assayedin vivo andin vitro for their effects on the development of the avian parasite,Plasmodium gallinaceum.Ang II and VC5 injected into the thoraces of the insects reduced mean intensities of infection in the mosquito salivary glands by 88% and 76%, respectively. Although the mechanism(s) of action is not completely understood, we have demonstrated that these peptides disrupt selectively the P.gallinaceumcell membrane. Additionally, incubation in vitro of sporozoites with VC5 reduced the infectivity of the parasites to their vertebrate host. VC5 has no observable agonist effects on vertebrates, and this makes it a promising drug for malaria prevention and chemotherapy.engAnti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalariaPlasmodiuminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL90. MACIEL C, DE OLIVEIRA JUNIOR VX.pdf90. MACIEL C, DE OLIVEIRA JUNIOR VX.pdfapplication/pdf252062https://www.arca.fiocruz.br/bitstream/icict/6661/1/90.%20MACIEL%20C%2c%20DE%20OLIVEIRA%20JUNIOR%20VX.pdf7817dc08e3a796e7017a66c403a28569MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6661/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT90. 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dc.title.pt_BR.fl_str_mv Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
title Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
spellingShingle Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
Maciel, Ceres
Malaria
Plasmodium
title_short Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
title_full Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
title_fullStr Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
title_full_unstemmed Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
title_sort Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
author Maciel, Ceres
author_facet Maciel, Ceres
Oliveira Junior, Vani Xavier de
Fazio, Marcos Antonio
Pimenta, Rafael Nacif
Miranda, Antonio
Pimenta, Paulo Filemon Paolucci
Capurro, Margareth Lara
author_role author
author2 Oliveira Junior, Vani Xavier de
Fazio, Marcos Antonio
Pimenta, Rafael Nacif
Miranda, Antonio
Pimenta, Paulo Filemon Paolucci
Capurro, Margareth Lara
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maciel, Ceres
Oliveira Junior, Vani Xavier de
Fazio, Marcos Antonio
Pimenta, Rafael Nacif
Miranda, Antonio
Pimenta, Paulo Filemon Paolucci
Capurro, Margareth Lara
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium
topic Malaria
Plasmodium
description FAPESP, CNPq
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-07-09T17:38:14Z
dc.date.available.fl_str_mv 2013-07-09T17:38:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACIEL, Ceres et al. Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides. PLoS ONE, v. 3, n. 9, p. 1-8, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6661
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0003296
identifier_str_mv MACIEL, Ceres et al. Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides. PLoS ONE, v. 3, n. 9, p. 1-8, 2008.
10.1371/journal.pone.0003296
url https://www.arca.fiocruz.br/handle/icict/6661
dc.language.iso.fl_str_mv eng
language eng
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