Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo

Detalhes bibliográficos
Autor(a) principal: Lacorte, J. Guilherme
Data de Publicação: 1944
Outros Autores: Santos, Mário
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51204
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
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spelling Lacorte, J. GuilhermeSantos, Mário2022-02-15T13:51:42Z2022-02-15T13:51:42Z1944LACORTE, J. Guilherme; SANTOS, Mário. Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 41, n. 3, p. 1 - 3, 1944.0074-0206https://www.arca.fiocruz.br/handle/icict/5120410.1590/S0074-027619440006000031678-8060porFundação Oswaldo Cruz. Instituto Oswaldo Cruz.EstudosPneumococoInfluência PHFormação da CápsulaEstudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.One of the features of pneumococcus which has deserved the attention of investigators is the capsule. Since Pasteur, Chamberland and Roux (1881) several functions have been ascribed to it as well as peculiar properties. In the present paper, we take into consideration one only aspect of this problem; it is the relationship which there possibly may be between acidity of the culture medium and the power of capsule formation by pneumococcus. As it is known, this germ requires for its development 7.8 as an optimum pH, but maintains its biological activities down to 5.6. These variations do not take place without large alterations, particularly of the capsule, not only from the morphological but also from the chemical viewpoint. The diameter of the mucous envelopment of the pneumococcus decreases in proportion to the increase of acidity down to its complete extinction. This fact has been regarded by investigators as a biological feature inhe¬ring to the germ itself and as proceeding of self-defense. In an acid medium the existing capsule is destroyed and the germ does not produce it again; consequently, acidity inhibits the formation of the capsule. We tried to check how this phenomenon comes to pass and to elucidated it. As we know, the fundamental compound of the pneumococcus capsule is mucin. In the first place, we experimented the action of acidity on same in the following manner: Mucin extracted from bovine submaxillary gland is precipitated by HC1 at a determined concentration degree; the mucin dissolves again and precipi¬tates in function of this concentration. This property of mucin (solubility in acid medium) modifies a little the interpretation of the mechanism of disappearance of the capsule from the said germ in the culture medium. Indeed: The acidification of the medium consecutive to the growth of pneumococcus reduces the dimensions of the capsule until causing its com¬plete disappearance; but on transferring this strain to new optimum cultiva¬ting conditions the capsule appears again exhuberantly, at times as anteriorly, although with biased virulence. Linking these two facts we draw the following conclusions: Pneumo¬coccus does not lose its capacity of capsule formation in an acid medium; but mucin, whilst being produced, is entirely dissolved in this medium by the aid of acidity; we venture to state that, in spite of medium acidity, the capacity of capsule production is a constant feature of pneumococcus and that the disappearance of the capsule does not depend on the pneumococcus in itself when it produces smooth colonies, but on the chemical properties of mucin, mainly on its solubility in acid medium.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
title Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
spellingShingle Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
Lacorte, J. Guilherme
Estudos
Pneumococo
Influência PH
Formação da Cápsula
title_short Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
title_full Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
title_fullStr Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
title_full_unstemmed Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
title_sort Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo
author Lacorte, J. Guilherme
author_facet Lacorte, J. Guilherme
Santos, Mário
author_role author
author2 Santos, Mário
author2_role author
dc.contributor.author.fl_str_mv Lacorte, J. Guilherme
Santos, Mário
dc.subject.other.pt_BR.fl_str_mv Estudos
Pneumococo
Influência PH
Formação da Cápsula
topic Estudos
Pneumococo
Influência PH
Formação da Cápsula
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate 1944
dc.date.issued.fl_str_mv 1944
dc.date.accessioned.fl_str_mv 2022-02-15T13:51:42Z
dc.date.available.fl_str_mv 2022-02-15T13:51:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LACORTE, J. Guilherme; SANTOS, Mário. Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 41, n. 3, p. 1 - 3, 1944.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51204
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761944000600003
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv LACORTE, J. Guilherme; SANTOS, Mário. Estudos sôbre o pneumococo: 4a. nota - Influência do pH do meio sôbre a formação da cápsula pelo pneumococo. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 41, n. 3, p. 1 - 3, 1944.
0074-0206
10.1590/S0074-02761944000600003
1678-8060
url https://www.arca.fiocruz.br/handle/icict/51204
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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