The progression rate of spinocerebellar ataxia type 2 changes with stage of disease

Detalhes bibliográficos
Autor(a) principal: Monte, Thais Lampert
Data de Publicação: 2018
Outros Autores: Reckziegel, Estela da Rosa, Augustin, Marina Coutinho, Coelho, Lucas D. Locks, Santos, Amanda Senna P., Furtado, Gabriel Vasata, Mattos, Eduardo Preusser de, Pedroso, José Luiz, Barsottini, Orlando Póvoas, Vargas, Fernando Regla, Pereira, Maria-Luiza Saraiva, Camey, Suzi Alves, Leotti, Vanessa Bielefeldt, Jardim, Laura Bannach, Rede Neurogenética
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29451
Resumo: Hospital de Clínicas de Porto Alegre. Serviço de Neurologia. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Ciências Médicas. Porto Alegre, RS, Brasil.
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spelling Monte, Thais LampertReckziegel, Estela da RosaAugustin, Marina CoutinhoCoelho, Lucas D. LocksSantos, Amanda Senna P.Furtado, Gabriel VasataMattos, Eduardo Preusser dePedroso, José LuizBarsottini, Orlando PóvoasVargas, Fernando ReglaPereira, Maria-Luiza SaraivaCamey, Suzi AlvesLeotti, Vanessa BielefeldtJardim, Laura BannachRede Neurogenética2018-10-09T12:05:47Z2018-10-09T12:05:47Z2018MONTE, Thais Lampert; et al. The progression rate of spinocerebellar ataxia type 2 changes with stage of disease. Orphanet Journal of Rare Diseases, v.13, n.20, 8p, 2018.1750-1172https://www.arca.fiocruz.br/handle/icict/2945110.1186/s13023-017-0725-yengBioMed CentralHistória NaturalAtaxia espinocerebelar tipo 2Taxa de progressãoNatural historyNESSCAProgression rateSARASCAFISpinocerebellar ataxia type 2The progression rate of spinocerebellar ataxia type 2 changes with stage of diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital de Clínicas de Porto Alegre. Serviço de Neurologia. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Ciências Médicas. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Laboratório de Identificação Genética. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Laboratório de Identificação Genética. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Setor de Neurologia Geral e Ataxias. Disciplina de Neurologia Clínica. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Setor de Neurologia Geral e Ataxias. Disciplina de Neurologia Clínica. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. Rio de Janeiro, RJ. Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Genética e Biologia Celular. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Genética Médica Populacional Rio de Janeiro, RJ, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Laboratório de Identificação Genética. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Bioquímica. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Grupo de Pesquisa e Pós-Graduação. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Departamento de Estatística. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Departamento de Estatística. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. . Laboratório de Identificação Genética. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Medicina Interna. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Ciências Médicas. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil / Instituto Nacional de Genética Médica Populacional. Rio de Janeiro, RJ, Brasil.Spinocerebellar ataxia type 2 (SCA2) affects several neurological structures, giving rise to multiple symptoms. However, only the natural history of ataxia is well known, as measured during the study duration. We aimed to describe the progression rate of ataxia, by the Scale for the Assessment and Rating of Ataxia (SARA), as well as the progression rate of the overall neurological picture, by the Neurological Examination Score for Spinocerebellar Ataxias (NESSCA), and not only during the study duration but also in a disease duration model. Comparisons between these models might allow us to explore whether progression is linear during the disease duration in SCA2; and to look for potential modifiers.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29451/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfernando2_vargas_etal_IOC_2018.pdffernando2_vargas_etal_IOC_2018.pdfapplication/pdf584321https://www.arca.fiocruz.br/bitstream/icict/29451/2/fernando2_vargas_etal_IOC_2018.pdf2dfc01d479707b109a6808a7a8667439MD52TEXTfernando2_vargas_etal_IOC_2018.pdf.txtfernando2_vargas_etal_IOC_2018.pdf.txtExtracted texttext/plain40620https://www.arca.fiocruz.br/bitstream/icict/29451/3/fernando2_vargas_etal_IOC_2018.pdf.txt83a19fd2d7a02f934c1bb7866c254976MD53icict/294512018-10-10 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dc.title.pt_BR.fl_str_mv The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
title The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
spellingShingle The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
Monte, Thais Lampert
História Natural
Ataxia espinocerebelar tipo 2
Taxa de progressão
Natural history
NESSCA
Progression rate
SARA
SCAFI
Spinocerebellar ataxia type 2
title_short The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
title_full The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
title_fullStr The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
title_full_unstemmed The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
title_sort The progression rate of spinocerebellar ataxia type 2 changes with stage of disease
author Monte, Thais Lampert
author_facet Monte, Thais Lampert
Reckziegel, Estela da Rosa
Augustin, Marina Coutinho
Coelho, Lucas D. Locks
Santos, Amanda Senna P.
Furtado, Gabriel Vasata
Mattos, Eduardo Preusser de
Pedroso, José Luiz
Barsottini, Orlando Póvoas
Vargas, Fernando Regla
Pereira, Maria-Luiza Saraiva
Camey, Suzi Alves
Leotti, Vanessa Bielefeldt
Jardim, Laura Bannach
Rede Neurogenética
author_role author
author2 Reckziegel, Estela da Rosa
Augustin, Marina Coutinho
Coelho, Lucas D. Locks
Santos, Amanda Senna P.
Furtado, Gabriel Vasata
Mattos, Eduardo Preusser de
Pedroso, José Luiz
Barsottini, Orlando Póvoas
Vargas, Fernando Regla
Pereira, Maria-Luiza Saraiva
Camey, Suzi Alves
Leotti, Vanessa Bielefeldt
Jardim, Laura Bannach
Rede Neurogenética
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monte, Thais Lampert
Reckziegel, Estela da Rosa
Augustin, Marina Coutinho
Coelho, Lucas D. Locks
Santos, Amanda Senna P.
Furtado, Gabriel Vasata
Mattos, Eduardo Preusser de
Pedroso, José Luiz
Barsottini, Orlando Póvoas
Vargas, Fernando Regla
Pereira, Maria-Luiza Saraiva
Camey, Suzi Alves
Leotti, Vanessa Bielefeldt
Jardim, Laura Bannach
Rede Neurogenética
dc.subject.other.pt_BR.fl_str_mv História Natural
Ataxia espinocerebelar tipo 2
Taxa de progressão
topic História Natural
Ataxia espinocerebelar tipo 2
Taxa de progressão
Natural history
NESSCA
Progression rate
SARA
SCAFI
Spinocerebellar ataxia type 2
dc.subject.en.pt_BR.fl_str_mv Natural history
NESSCA
Progression rate
SARA
SCAFI
Spinocerebellar ataxia type 2
description Hospital de Clínicas de Porto Alegre. Serviço de Neurologia. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Ciências Médicas. Porto Alegre, RS, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-09T12:05:47Z
dc.date.available.fl_str_mv 2018-10-09T12:05:47Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MONTE, Thais Lampert; et al. The progression rate of spinocerebellar ataxia type 2 changes with stage of disease. Orphanet Journal of Rare Diseases, v.13, n.20, 8p, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29451
dc.identifier.issn.pt_BR.fl_str_mv 1750-1172
dc.identifier.doi.none.fl_str_mv 10.1186/s13023-017-0725-y
identifier_str_mv MONTE, Thais Lampert; et al. The progression rate of spinocerebellar ataxia type 2 changes with stage of disease. Orphanet Journal of Rare Diseases, v.13, n.20, 8p, 2018.
1750-1172
10.1186/s13023-017-0725-y
url https://www.arca.fiocruz.br/handle/icict/29451
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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