Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14312 |
Resumo: | David Geffen UCLA School of Medicine. Los Angeles, CA, USA. |
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Yeganeh, NavaWatts, D. HeatherCamarca, MargaretSoares, GabrielJoao, EsauPilotto, José HenriqueGray, GlendaTheron, GerhardSantos, BrenoFonseca, RosanaKreitchmann, RegisPinto, JorgeMussi-Pinhata, MarisaCeriotto, MarianaMachado, DaisyVeloso, Valdiléa G.Grinzstejn, BeatrizMorgado, Mariza G.Bryson, YvonneMofenson, Lynne M.Nielsen-Saines, Karin2016-05-17T13:55:29Z2016-05-17T13:55:29Z2015YEGANEH, Nava; et al. Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study. Pediatr Infect Dis J.. v.34, n.3, p.e52–e57, Mar. 2015.0891-3668https://www.arca.fiocruz.br/handle/icict/1431210.1097/INF.00000000000005781532-0987engLippincott, Williams & WilkinsTransmissão de mãe para filhoHIVCuidado Pré-NatalSífilis CongênitaHIV mother to child transmissionPrenatal careCongenital syphilisSyphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDavid Geffen UCLA School of Medicine. Los Angeles, CA, USA.National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, MD, USA.Westat, Rockville, MD, USA.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.University of Witwatersrand. Chris Hani Baragwanath Hospital. Perinatal HIV Research Unit. Johannesburg, South Africa.Stellenbosch University. Tygerberg Hospital. Cape Town, South Africa.Hospital Conceicao. Porto Alegre, RS, Brasil.Hospital Femina. Porto Alegre, RS, Brasil.Irmandade da Santa Casa de Misericórdia de Porto Alegre. Porto Alegre, RS, Brasil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Ribeirão Preto, SP, Brasil.Foundation for Maternal and Infant Health (FUNDASAMIN). Buenos Aires, Argentina.Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, MD, USA.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.Background—Untreated syphilis during pregnancy is associated with spontaneous abortion, stillbirth, prematurity and infant mortality. Syphilis may facilitate HIV transmission, which is especially concerning in low and middle income countries where both diseases are common. Methods—We performed an analysis of data available from NICHD/HPTN 040 (P1043), a study focused on the prevention of intrapartum HIV transmission to 1684 infants born to 1664 untreated HIV-infected women. The present analysis evaluates risk factors and outcomes associated with a syphilis diagnosis in this cohort of HIV-infected women and their infants. Results—Approximately 10% (n=171) of women enrolled had serological evidence of syphilis without adequate treatment documented and 1.4% (n=24) infants were dually HIV and syphilis infected. Multivariate logistic analysis showed that compared to HIV-infected women, co-infected women were significantly more likely to self-identify as non-white (AOR 2.5, 95% CI 1.5-4.2), to consume alcohol during pregnancy (AOR 1.5, 95% CI 1.1-2.1) and to transmit HIV to their infants (AOR 2.1, 95% CI 1.3-3.4), with 88% of HIV infections being acquired in-utero. As compared to HIV infected or HIV exposed infants, co-infected infants were significantly more likely to be born to mothers with VDRL titers ≥1:16 (AOR 3, 95% CI 1.1-8.2) and higher viral loads (AOR 1.5 95% CI 1.1-1.9). Of 6 newborns with symptomatic syphilis, 2 expired shortly after birth, and 2 were HIV-infected. Conclusion—Syphilis continues to be a common co-infection in HIV-infected women and can facilitate in utero transmission of HIV to infants. Most infants are asymptomatic at birth, but those with symptoms have high mortality rates.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14312/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjosehenrique2_pilotto_etal_IOC_2015.pdfjosehenrique2_pilotto_etal_IOC_2015.pdfapplication/pdf294424https://www.arca.fiocruz.br/bitstream/icict/14312/2/josehenrique2_pilotto_etal_IOC_2015.pdfe2fecd876d73845ec3740216f2fc610eMD52TEXTjosehenrique2_pilotto_etal_IOC_2015.pdf.txtjosehenrique2_pilotto_etal_IOC_2015.pdf.txtExtracted texttext/plain41992https://www.arca.fiocruz.br/bitstream/icict/14312/3/josehenrique2_pilotto_etal_IOC_2015.pdf.txt8bb9931c66926f67eb2f642d0434301bMD53icict/143122023-09-04 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| dc.title.pt_BR.fl_str_mv |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study |
| title |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study |
| spellingShingle |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study Yeganeh, Nava Transmissão de mãe para filho HIV Cuidado Pré-Natal Sífilis Congênita HIV mother to child transmission Prenatal care Congenital syphilis |
| title_short |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study |
| title_full |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study |
| title_fullStr |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study |
| title_full_unstemmed |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study |
| title_sort |
Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study |
| author |
Yeganeh, Nava |
| author_facet |
Yeganeh, Nava Watts, D. Heather Camarca, Margaret Soares, Gabriel Joao, Esau Pilotto, José Henrique Gray, Glenda Theron, Gerhard Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa Ceriotto, Mariana Machado, Daisy Veloso, Valdiléa G. Grinzstejn, Beatriz Morgado, Mariza G. Bryson, Yvonne Mofenson, Lynne M. Nielsen-Saines, Karin |
| author_role |
author |
| author2 |
Watts, D. Heather Camarca, Margaret Soares, Gabriel Joao, Esau Pilotto, José Henrique Gray, Glenda Theron, Gerhard Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa Ceriotto, Mariana Machado, Daisy Veloso, Valdiléa G. Grinzstejn, Beatriz Morgado, Mariza G. Bryson, Yvonne Mofenson, Lynne M. Nielsen-Saines, Karin |
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author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Yeganeh, Nava Watts, D. Heather Camarca, Margaret Soares, Gabriel Joao, Esau Pilotto, José Henrique Gray, Glenda Theron, Gerhard Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa Ceriotto, Mariana Machado, Daisy Veloso, Valdiléa G. Grinzstejn, Beatriz Morgado, Mariza G. Bryson, Yvonne Mofenson, Lynne M. Nielsen-Saines, Karin |
| dc.subject.other.pt_BR.fl_str_mv |
Transmissão de mãe para filho HIV Cuidado Pré-Natal Sífilis Congênita |
| topic |
Transmissão de mãe para filho HIV Cuidado Pré-Natal Sífilis Congênita HIV mother to child transmission Prenatal care Congenital syphilis |
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HIV mother to child transmission Prenatal care Congenital syphilis |
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David Geffen UCLA School of Medicine. Los Angeles, CA, USA. |
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2015 |
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2015 |
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2016-05-17T13:55:29Z |
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2016-05-17T13:55:29Z |
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YEGANEH, Nava; et al. Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study. Pediatr Infect Dis J.. v.34, n.3, p.e52–e57, Mar. 2015. |
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https://www.arca.fiocruz.br/handle/icict/14312 |
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0891-3668 |
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10.1097/INF.0000000000000578 |
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1532-0987 |
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YEGANEH, Nava; et al. Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study. Pediatr Infect Dis J.. v.34, n.3, p.e52–e57, Mar. 2015. 0891-3668 10.1097/INF.0000000000000578 1532-0987 |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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