Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact

Detalhes bibliográficos
Autor(a) principal: Monteiro, Thaíssa S.
Data de Publicação: 2017
Outros Autores: Correia, Marcelo G., Golebiovski, Wilma F., Barbosa, Giovanna Ianini F., Weksler, Clara, Lamas, Cristiane C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31316
Resumo: Instituto Nacional de Cardiologia. Departamento de doenças da válvula cardíaca. Rio de Janeiro, RJ, Brasil.
id CRUZ_e2d44a7637a1d99f1d6e1b216c29af4e
oai_identifier_str oai:www.arca.fiocruz.br:icict/31316
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Monteiro, Thaíssa S.Correia, Marcelo G.Golebiovski, Wilma F.Barbosa, Giovanna Ianini F.Weksler, ClaraLamas, Cristiane C.2019-01-28T11:11:13Z2019-01-28T11:11:13Z2017MONTEIRO, Thaíssa S. et al. Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact. Brazilian Journal of Infectious Diseases, v. 21, n. 3, p. 240-247, May/Jun. 2017.1413-8670https://www.arca.fiocruz.br/handle/icict/3131610.1016/j.bjid.2017.01.0061678-4391engElsevierAsymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impactinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Cardiologia. Departamento de doenças da válvula cardíaca. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Departamento de Bioestatística. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Departamento de doenças da válvula cardíaca. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Unidade de Controle de Infecções. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Departamento de doenças da válvula cardíaca. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Departamento de doenças da válvula cardíaca. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Rio de Janeiro, RJ, Brasil.Background: Embolic complications of infective endocarditis are common. The impact of asymptomatic embolism is uncertain. Objectives: To determine the frequency of emboli due to IE and to identify events associated with embolism. Methods: Retrospective analysis of an endocarditis database, prospectively implemented, with a post hoc study driven by analysis of data on embolic events. Data was obtained from the International Collaboration Endocarditis case report forms and additional information on embolic events and imaging reports were obtained from the medical records. Variables associated with embolism were analyzed by the statistical software R version 3.1.0. Results: In the study period, 2006-2011, 136 episodes of definite infective endocarditis were included. The most common complication was heart failure (55.1%), followed by embolism (50%). Among the 100 medical records analyzed for emboli in left-sided infective endocarditis, 36 (36%) were found to have had asymptomatic events, 11 (11%) to the central nervous system and 28 (28%) to the spleen. Cardiac surgery was performed in 98/136 (72%). In the multivariate analysis, splenomegaly was the only associated factor for embolism to any site (p<0.01, OR 4.7, 95% CI 2.04-11). Factors associated with embolism to the spleen were positive blood cultures (p=0.05, OR 8.9, 95% CI 1.45-177) and splenomegaly (p<0.01, OR 9.28, 95% CI 3.32-29); those associated to the central nervous system were infective endocarditis of the mitral valve (p<0.05, OR 3.5, 95% CI 1.23-10) and male gender (p<0.05, OR 3.2, 95% CI 1.04-10). Splenectomy and cardiac surgery did not impact on in-hospital mortality. Conclusions: Asymptomatic embolism to the central nervous system and to the spleen were frequent. Splenomegaly was consistently associated with embolic events.Infective endocarditisEmbolismAsymptomatic embolismSplenomegalyCardiac surgerySplenectomyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31316/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Monteiro_Thaíssa_etal_INI_2017.pdfve_Monteiro_Thaíssa_etal_INI_2017.pdfapplication/pdf612961https://www.arca.fiocruz.br/bitstream/icict/31316/2/ve_Monteiro_Tha%c3%adssa_etal_INI_2017.pdf65617226ceb7d4b094abe81e56efd491MD52TEXTve_Monteiro_Thaíssa_etal_INI_2017.pdf.txtve_Monteiro_Thaíssa_etal_INI_2017.pdf.txtExtracted texttext/plain39226https://www.arca.fiocruz.br/bitstream/icict/31316/3/ve_Monteiro_Tha%c3%adssa_etal_INI_2017.pdf.txt81363e799c76eb584a1966637efa83faMD53icict/313162023-10-28 13:57:47.646oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-28T16:57:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
title Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
spellingShingle Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
Monteiro, Thaíssa S.
Infective endocarditis
Embolism
Asymptomatic embolism
Splenomegaly
Cardiac surgery
Splenectomy
title_short Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
title_full Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
title_fullStr Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
title_full_unstemmed Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
title_sort Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
author Monteiro, Thaíssa S.
author_facet Monteiro, Thaíssa S.
Correia, Marcelo G.
Golebiovski, Wilma F.
Barbosa, Giovanna Ianini F.
Weksler, Clara
Lamas, Cristiane C.
author_role author
author2 Correia, Marcelo G.
Golebiovski, Wilma F.
Barbosa, Giovanna Ianini F.
Weksler, Clara
Lamas, Cristiane C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro, Thaíssa S.
Correia, Marcelo G.
Golebiovski, Wilma F.
Barbosa, Giovanna Ianini F.
Weksler, Clara
Lamas, Cristiane C.
dc.subject.en.pt_BR.fl_str_mv Infective endocarditis
Embolism
Asymptomatic embolism
Splenomegaly
Cardiac surgery
Splenectomy
topic Infective endocarditis
Embolism
Asymptomatic embolism
Splenomegaly
Cardiac surgery
Splenectomy
description Instituto Nacional de Cardiologia. Departamento de doenças da válvula cardíaca. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-01-28T11:11:13Z
dc.date.available.fl_str_mv 2019-01-28T11:11:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MONTEIRO, Thaíssa S. et al. Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact. Brazilian Journal of Infectious Diseases, v. 21, n. 3, p. 240-247, May/Jun. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31316
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2017.01.006
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv MONTEIRO, Thaíssa S. et al. Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact. Brazilian Journal of Infectious Diseases, v. 21, n. 3, p. 240-247, May/Jun. 2017.
1413-8670
10.1016/j.bjid.2017.01.006
1678-4391
url https://www.arca.fiocruz.br/handle/icict/31316
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31316/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31316/2/ve_Monteiro_Tha%c3%adssa_etal_INI_2017.pdf
https://www.arca.fiocruz.br/bitstream/icict/31316/3/ve_Monteiro_Tha%c3%adssa_etal_INI_2017.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
65617226ceb7d4b094abe81e56efd491
81363e799c76eb584a1966637efa83fa
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008856410750976

Registros relacionados