Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins

Detalhes bibliográficos
Autor(a) principal: Bastos, Tanira Matutino
Data de Publicação: 2019
Outros Autores: Russo, Helena Mannochio, Moretti, Nilmar Silvio, Schenkman, Sergio, Marcourt, Laurence, Gupta, Mahabir Prashad, Wolfender, Jean-Luc, Queiroz, Emerson Ferreira, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34633
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 015/22031-0 to S.S. and N.M., Grant 2018/09948-0 to N.M.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). SS and M.S are the recipients of a fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
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spelling Bastos, Tanira MatutinoRusso, Helena MannochioMoretti, Nilmar SilvioSchenkman, SergioMarcourt, LaurenceGupta, Mahabir PrashadWolfender, Jean-LucQueiroz, Emerson FerreiraSoares, Milena Botelho Pereira2019-08-06T17:59:50Z2019-08-06T17:59:50Z2019BASTOS,Tanira Matutino et al. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules, v. 24, p. 1-13, 2019.1420-3049https://www.arca.fiocruz.br/handle/icict/3463310.3390/molecules24071299Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 015/22031-0 to S.S. and N.M., Grant 2018/09948-0 to N.M.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). SS and M.S are the recipients of a fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.Universidade Federal de São Paulo. Departmento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Departmento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.University of Panama. College of Pharmacy. Center for Pharmacognostic Research on Panamanian Flora. Panama, Panama.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.University of Geneva. University of Lausanne. School of Pharmaceutical Sciences. Geneva, Switzerland.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets for the identification of novel bioactive compounds against the parasite and with low toxicity. Silent information regulator 2 (Sir2) enzymes, or sirtuins, have emerged as attractive targets for the development of novel antitrypanosomatid agents. In the present work, we evaluated the inhibitory effect of natural compounds isolated from cashew nut (Anacardium occidentale, L. Anacardiaceae) against the target enzymes TcSir2rp1 and TcSir2rp3 as well as the parasite. Two derivates of cardol (1, 2), cardanol (3, 4), and anacardic acid (5, 6) were investigated. The two anacardic acids (5, 6) inhibited both TcSir2rp1 and TcSir2rp3, while the cardol compound (2) inhibited only TcSir2rp1. The most potent sirtuin inhibitor active against the parasite was the cardol compound (2), with an EC50 value of 12.25 µM, similar to that of benznidazole. Additionally, compounds (1, 4), which were inactive against the sirtuin targets, presented anti-T. cruzi effects. In conclusion, our results showed the potential of Anacardium occidentale compounds for the development of potential sirtuin inhibitors and anti-Trypanosoma cruzi agents.engMDPITrypanosoma cruziSirtuinsAnacardium occidentaleDescoberta de drogasTrypanosoma cruziSirtuinsAnacardium occidentaleDrug discoveryChemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34633/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBastos, T.M. Chemical Constituents..2019.pdfBastos, T.M. Chemical Constituents..2019.pdfapplication/pdf2058509https://www.arca.fiocruz.br/bitstream/icict/34633/2/Bastos%2c%20T.M.%20Chemical%20Constituents..2019.pdf1a65d1df64e67868d881ad58bda54db6MD52TEXTBastos, T.M. Chemical Constituents..2019.pdf.txtBastos, T.M. Chemical Constituents..2019.pdf.txtExtracted texttext/plain51332https://www.arca.fiocruz.br/bitstream/icict/34633/3/Bastos%2c%20T.M.%20Chemical%20Constituents..2019.pdf.txt854bfd9fb04e762aac8d2cf473b0f863MD53icict/346332023-03-15 14:34:18.193oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
title Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
spellingShingle Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
Bastos, Tanira Matutino
Trypanosoma cruzi
Sirtuins
Anacardium occidentale
Descoberta de drogas
Trypanosoma cruzi
Sirtuins
Anacardium occidentale
Drug discovery
title_short Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
title_full Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
title_fullStr Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
title_full_unstemmed Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
title_sort Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
author Bastos, Tanira Matutino
author_facet Bastos, Tanira Matutino
Russo, Helena Mannochio
Moretti, Nilmar Silvio
Schenkman, Sergio
Marcourt, Laurence
Gupta, Mahabir Prashad
Wolfender, Jean-Luc
Queiroz, Emerson Ferreira
Soares, Milena Botelho Pereira
author_role author
author2 Russo, Helena Mannochio
Moretti, Nilmar Silvio
Schenkman, Sergio
Marcourt, Laurence
Gupta, Mahabir Prashad
Wolfender, Jean-Luc
Queiroz, Emerson Ferreira
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bastos, Tanira Matutino
Russo, Helena Mannochio
Moretti, Nilmar Silvio
Schenkman, Sergio
Marcourt, Laurence
Gupta, Mahabir Prashad
Wolfender, Jean-Luc
Queiroz, Emerson Ferreira
Soares, Milena Botelho Pereira
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Sirtuins
Anacardium occidentale
Descoberta de drogas
topic Trypanosoma cruzi
Sirtuins
Anacardium occidentale
Descoberta de drogas
Trypanosoma cruzi
Sirtuins
Anacardium occidentale
Drug discovery
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Sirtuins
Anacardium occidentale
Drug discovery
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 015/22031-0 to S.S. and N.M., Grant 2018/09948-0 to N.M.); and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). SS and M.S are the recipients of a fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-08-06T17:59:50Z
dc.date.available.fl_str_mv 2019-08-06T17:59:50Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BASTOS,Tanira Matutino et al. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules, v. 24, p. 1-13, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34633
dc.identifier.issn.pt_BR.fl_str_mv 1420-3049
dc.identifier.doi.none.fl_str_mv 10.3390/molecules24071299
identifier_str_mv BASTOS,Tanira Matutino et al. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules, v. 24, p. 1-13, 2019.
1420-3049
10.3390/molecules24071299
url https://www.arca.fiocruz.br/handle/icict/34633
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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