Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection

Detalhes bibliográficos
Autor(a) principal: Duque, Thabata L. A.
Data de Publicação: 2019
Outros Autores: Cascabulho, Cynthia M., Oliveira, Gabriel M., Henriques-Pons, Andrea, Menna-Barreto, Rubem F. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41368
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.
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spelling Duque, Thabata L. A.Cascabulho, Cynthia M.Oliveira, Gabriel M.Henriques-Pons, AndreaMenna-Barreto, Rubem F. S.2020-05-24T13:58:09Z2020-05-24T13:58:09Z2019DUQUE, Thabata L. A. et al. Rapamycin treatment reduces acute Moyocarditis induced by Trypanosoma cruz infection. Journal of Innate Immunity, p. 1-12, Dec. 2019.1662-811xhttps://www.arca.fiocruz.br/handle/icict/4136810.1159/0005043221662-8128engKargerTrypanosma cruziDoença de ChagasAutofagiaRapamycinInfecção agudaTrypanosoma cruziChagas DiseaseAutophagyRapamycinAcute infectionRapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Chagas disease affects millions of people mainly in Latin America and is a protozoan illness caused by the parasite Trypanosoma cruzi. Chagasic cardiomyopathy is the leading cause of mortality of infected patients, due to compromised electrical and mechanical cardiac function induced by tissue remodeling, especially fibrosis, and lymphocytic infiltration. Some cellular biochemical pathways can be protective to the heart, and we tested if the in vivo activation of the autophagic machinery by rapamycin could reduce parasite-induced myocarditis. Regarding the expression of LC3, an autophagy marker, we observed its upregulation in the cardiac tissue of infected untreated mice. However, after rapamycin treatment, an autophagy inducer, infected mice showed reduced electrical cardiac dysfunctions, myocarditis, cardiac damage, and reduced production of pro-inflammatory cytokines by the heart. On the other hand, the parasite's life cycle was not affected, and we observed no modulations in cardiac tissue or blood parasitemia. Our data indicate that, at least partially, autophagy induction controls inflammation in the heart¸ illustrating the complexity of the pathways that concur to the development of the infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41368/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRubemBarerto_GabrielOliveira_etal_IOC_2019.pdfRubemBarerto_GabrielOliveira_etal_IOC_2019.pdfapplication/pdf1362246https://www.arca.fiocruz.br/bitstream/icict/41368/2/RubemBarerto_GabrielOliveira_etal_IOC_2019.pdf957272473118797a6761ec99cb93ccc8MD52TEXTRubemBarerto_GabrielOliveira_etal_IOC_2019.pdf.txtRubemBarerto_GabrielOliveira_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
title Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
spellingShingle Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
Duque, Thabata L. A.
Trypanosma cruzi
Doença de Chagas
Autofagia
Rapamycin
Infecção aguda
Trypanosoma cruzi
Chagas Disease
Autophagy
Rapamycin
Acute infection
title_short Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
title_full Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
title_fullStr Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
title_full_unstemmed Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
title_sort Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
author Duque, Thabata L. A.
author_facet Duque, Thabata L. A.
Cascabulho, Cynthia M.
Oliveira, Gabriel M.
Henriques-Pons, Andrea
Menna-Barreto, Rubem F. S.
author_role author
author2 Cascabulho, Cynthia M.
Oliveira, Gabriel M.
Henriques-Pons, Andrea
Menna-Barreto, Rubem F. S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Duque, Thabata L. A.
Cascabulho, Cynthia M.
Oliveira, Gabriel M.
Henriques-Pons, Andrea
Menna-Barreto, Rubem F. S.
dc.subject.other.pt_BR.fl_str_mv Trypanosma cruzi
Doença de Chagas
Autofagia
Rapamycin
Infecção aguda
topic Trypanosma cruzi
Doença de Chagas
Autofagia
Rapamycin
Infecção aguda
Trypanosoma cruzi
Chagas Disease
Autophagy
Rapamycin
Acute infection
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chagas Disease
Autophagy
Rapamycin
Acute infection
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-05-24T13:58:09Z
dc.date.available.fl_str_mv 2020-05-24T13:58:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DUQUE, Thabata L. A. et al. Rapamycin treatment reduces acute Moyocarditis induced by Trypanosoma cruz infection. Journal of Innate Immunity, p. 1-12, Dec. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41368
dc.identifier.issn.pt_BR.fl_str_mv 1662-811x
dc.identifier.doi.none.fl_str_mv 10.1159/000504322
dc.identifier.eissn.none.fl_str_mv 1662-8128
identifier_str_mv DUQUE, Thabata L. A. et al. Rapamycin treatment reduces acute Moyocarditis induced by Trypanosoma cruz infection. Journal of Innate Immunity, p. 1-12, Dec. 2019.
1662-811x
10.1159/000504322
1662-8128
url https://www.arca.fiocruz.br/handle/icict/41368
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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